Development Level

Tchem 15 | 1,598
Tbio 11 | 11,445

IMPC Phenotype

abnormal embryo size 3 | 220
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
decreased circulating amylase ... 2 | 28
decreased circulating glycerol... 2 | 16
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal clavicle morphology 1 | 6
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
cataract 1 | 92
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
hyperactivity 1 | 148
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
limb grasping 1 | 41
mammalian phenotype 1 | 17
small epididymis 1 | 3

Disease

Carcinoma 20 | 11,493
osteosarcoma 16 | 7,950
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
psoriasis 15 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
group 3 medulloblastoma 13 | 4,104
ovarian cancer 13 | 8,520
Kidney cancer 11 | 2,613
ependymoma 11 | 4,679
Astrocytoma, Pilocytic 10 | 3,081
astrocytic glioma 10 | 2,597
lung cancer 10 | 4,740
oligodendroglioma 10 | 2,850
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 8 | 3,035
ulcerative colitis 8 | 1,819
Hypertension 7 | 396
cystic fibrosis 7 | 1,696
interstitial cystitis 7 | 2,312
subependymal giant cell astrocytoma 7 | 2,287
Pick disease 6 | 1,894
colon cancer 6 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
non-small cell lung cancer 6 | 2,890
Bipolar Disorder 5 | 666
Breast cancer 5 | 3,578
Cancer 5 | 2,499
Hypertensive disease 5 | 292
Schnyder Corneal Dystrophy 5 | 23
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
tuberculosis 5 | 2,010
Autosomal recessive predisposition 4 | 1,442
Epilepsy 4 | 792
Neurodegenerative disease 4 | 414
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
malignant mesothelioma 4 | 3,232
pancreatic cancer 4 | 2,398
3p- syndrome 3 | 21
Barrett's esophagus 3 | 182
Brain Ischemia 3 | 110
Chronic Lymphocytic Leukemia 3 | 262
Depressive disorder 3 | 409
Low compliance bladder 3 | 11
Neurogenic bladder 3 | 16
Seizures 3 | 596
Status Epilepticus 3 | 98
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
invasive ductal carcinoma 3 | 2,951
Adenoma 2 | 167
Adult onset 2 | 82
Autosomal dominant cerebellar ataxia 2 | 33
Autosomal dominant nonsyndromic deafness 11 2 | 5
Autosomal dominant nonsyndromic deafness 25 2 | 6
Brain Hypoxia 2 | 2
Brody myopathy 2 | 3
Cardiomegaly 2 | 116
Cerebellar Ataxia 2 | 304
Chronic obstructive pulmonary disease 2 | 184
Dementia 2 | 175
Diabetes Mellitus, Experimental 2 | 108
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Epilepsy, Temporal Lobe 2 | 23
Gaucher disease type 1 2 | 180
Heart disease 2 | 306
Hyperalgesia 2 | 83
Hypoxia, Brain 2 | 2
Liver cancer 2 | 604
Major Depressive Disorder 2 | 301
Mental Depression 2 | 333
Mood Disorders 2 | 184
Muscle hypotonia 2 | 571
Myocardial Reperfusion Injury 2 | 37
Myopathies, Structural, Congenital 2 | 15
Obesity 2 | 678
Parkinson's disease 2 | 392
Rheumatoid arthritis 2 | 1,191
Severe combined immunodeficiency 2 | 51
Stormorken syndrome 2 | 6
Tubular aggregate myopathy 2 | 3
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
group 4 medulloblastoma 2 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
progressive supranuclear palsy 2 | 676
Dowling-Degos disease 1 | 7
Tinea manuum 1 | 4

Tissue

Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Liver and Pancreas 24 | 16,750
Blood and immune system 22 | 16,909
Cardiovascular System 21 | 15,192
Respiratory system 21 | 16,393

Target Family

Ion Channel 14 | 344
Transporter 9 | 473
Non-IDG 3 | 12,091

Reactome Pathway

Platelet calcium homeostasis 26 | 26
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Short transient receptor potential channel 7 TRPC7 Tchem Ion Channel -2.43775 199.8 220
Protein orai-2 ORAI2 Tbio Non-IDG -1.27446 13.1 113
Plasma membrane calcium-transporting ATPase 1 ATP2B1 Tbio Transporter -2.01694 100.0 110
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 ATP2A3 Tbio Transporter -1.94217 94.1 100
P2X purinoceptor 3 P2RX3 Tchem Ion Channel -2.55623 360.2 162
Plasma membrane calcium-transporting ATPase 3 ATP2B3 Tbio Transporter -2.52332 332.0 52
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.70924 45.0 59
Sodium/calcium exchanger 1 SLC8A1 Tchem Transporter -2.52990 349.1 141