Development Level

Tbio 167 | 11,651
Tchem 56 | 1,388
Tclin 21 | 612
Tdark 12 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 16 | 499
decreased vertical activity 6 | 208
abnormal behavior 5 | 298
decreased body weight 5 | 161
enlarged heart 5 | 210
thrombocytopenia 5 | 56
decreased lean body mass 4 | 135
decreased prepulse inhibition 4 | 82
decreased total body fat amoun... 4 | 207
edema 4 | 59
increased circulating alkaline... 4 | 122
increased total body fat amoun... 4 | 134
short tibia 4 | 97
abnormal bone structure 3 | 187
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal testis morphology 3 | 43
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased hemoglobin content 3 | 68
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to t... 3 | 278
enlarged lymph nodes 3 | 37
increased lean body mass 3 | 172
increased startle reflex 3 | 112
male infertility 3 | 123
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal humerus morphology 2 | 11
absent vibrissae 2 | 12
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating phosphat... 2 | 27
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
increased aggression 1 | 4
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
limb grasping 1 | 41
premature death 1 | 5
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
thin ventricular wall 1 | 24
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 164 | 11,493
ovarian cancer 145 | 8,520
osteosarcoma 138 | 7,950
glioblastoma 126 | 5,792
Cancer 117 | 2,499
psoriasis 115 | 6,694
medulloblastoma, large-cell 109 | 6,241
lung cancer 103 | 4,740
atypical teratoid / rhabdoid tumor 92 | 5,112
ependymoma 89 | 4,679
Astrocytoma, Pilocytic 81 | 3,081
lung carcinoma 80 | 2,843
pancreatic cancer 80 | 2,398
invasive ductal carcinoma 79 | 2,951
Breast cancer 78 | 3,578
malignant mesothelioma 75 | 3,232
adult high grade glioma 74 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
lung adenocarcinoma 67 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 66 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 65 | 2,955
non-small cell lung cancer 65 | 2,890
group 3 medulloblastoma 61 | 4,104
subependymal giant cell astrocytoma 60 | 2,287
oligodendroglioma 57 | 2,850
diabetes mellitus 56 | 1,728
interstitial cystitis 55 | 2,312
primitive neuroectodermal tumor 53 | 3,035
tuberculosis 49 | 2,010
ulcerative colitis 48 | 1,819
Liver Cirrhosis, Experimental 47 | 769
Kidney cancer 46 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
astrocytic glioma 45 | 2,597
cystic fibrosis 45 | 1,696
Autosomal recessive predisposition 43 | 1,442
breast carcinoma 42 | 1,638
ductal carcinoma in situ 39 | 1,745
juvenile dermatomyositis 39 | 1,187
Pick disease 38 | 1,894
primary pancreatic ductal adenocarcinoma 38 | 1,109
Schizophrenia 36 | 1,160
colon cancer 36 | 1,478
group 4 medulloblastoma 36 | 1,855
astrocytoma 35 | 1,146
Kidney disease 33 | 430
Rheumatoid arthritis 33 | 1,191
pituitary cancer 33 | 1,972
Coronary artery disease 31 | 268
Cerebrovascular disease 30 | 238
Duchenne muscular dystrophy 30 | 601
Hypertension 30 | 396
Obesity 30 | 678
pancreatic carcinoma 30 | 562
Thrombocytopenia 29 | 197
adrenocortical carcinoma 28 | 1,428
Atherosclerosis 27 | 291
Multiple myeloma 27 | 1,332
Vascular disease 26 | 319
acute quadriplegic myopathy 26 | 1,158
esophageal adenocarcinoma 26 | 737
pediatric high grade glioma 26 | 1,064
primary Sjogren syndrome 26 | 735
gastric carcinoma 25 | 807
Bipolar Disorder 24 | 666
Heart disease 24 | 306
Hypertensive disease 24 | 292
Alzheimer's disease 23 | 658
Asthma 23 | 385
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 510
Arthritis 21 | 290
Depressive disorder 21 | 409
active ulcerative colitis 21 | 764
cutaneous lupus erythematosus 21 | 1,057
dermatomyositis 21 | 966
Liver disease 20 | 237
Waldenstrons macroglobulinemia 20 | 765
active Crohn's disease 20 | 922
mucosa-associated lymphoid tissue lymphoma 20 | 484
Breast Neoplasms 19 | 445
Liver Cirrhosis 19 | 181
Mammary Neoplasms 19 | 425
Prostatic Neoplasms 19 | 495
gastric cancer 19 | 459
Neoplasm Invasiveness 18 | 161
spina bifida 18 | 1,074
Down syndrome 17 | 499
Neurodegenerative disease 17 | 414
Osteoporosis 17 | 363
Stomach Neoplasms 17 | 300
Anemia 16 | 365
Carcinoma, Hepatocellular 16 | 228
Cardiomegaly 16 | 116
Chemical and Drug Induced Liver Injury 16 | 195
Liver carcinoma 16 | 240
Thrombophilia 16 | 38
fibroadenoma 16 | 559
hepatocellular carcinoma 16 | 547
Atopic dermatitis 15 | 952
Intellectual disability 15 | 1,016

Tissue

Endocrine System 252 | 18,159
Digestive Tract 251 | 17,369
Skin and soft tissues 248 | 17,230
Male tissues 247 | 17,142
Urinary Tract 247 | 16,678
Female tissues 246 | 17,400
Liver and Pancreas 246 | 16,750
Blood and immune system 244 | 16,909
Respiratory system 241 | 16,393
Nervous System 240 | 16,725
Cardiovascular System 231 | 15,192

Target Family

Non-IDG 158 | 12,091
Enzyme 52 | 4,145
Kinase 29 | 634
GPCR 9 | 408
Ion Channel 6 | 344
Epigenetic 1 | 242
Transporter 1 | 473

Reactome Pathway

Platelet activation, signaling... 256 | 256
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Secreted phosphoprotein 24 SPP2 Tbio Non-IDG -1.20992 21.1 29
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Testis-expressed protein 264 TEX264 Tdark Non-IDG 1.18 0.07 70
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Thrombopoietin receptor MPL Tclin Non-IDG -2.74303 582.0 186
Secretogranin-3 SCG3 Tbio Non-IDG -1.59072 42.1 169
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Platelet glycoprotein 4 CD36 Tbio Non-IDG -2.63884 376.0 1155