Development Level

Tbio 148 | 10,625
Tchem 80 | 1,890
Tclin 30 | 602
Tdark 16 | 7,003

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, incomple... 10 | 260
preweaning lethality, complete... 8 | 633
decreased body weight 7 | 174
decreased lean body mass 7 | 195
decreased bone mineral density 6 | 126
decreased total body fat amoun... 5 | 186
decreased body length 4 | 108
decreased bone mineral content 4 | 157
decreased circulating insulin ... 4 | 75
decreased circulating triglyce... 4 | 83
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
increased or absent threshold ... 4 | 128
increased total body fat amoun... 4 | 57
abnormal behavior 3 | 226
abnormal bone mineralization 3 | 55
abnormal retina morphology 3 | 100
decreased prepulse inhibition 3 | 52
hydrops fetalis 3 | 22
increased circulating HDL chol... 3 | 63
male infertility 3 | 62
thrombocytopenia 3 | 46
abnormal femur morphology 2 | 14
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased circulating amylase ... 2 | 24
decreased circulating bilirubi... 2 | 14
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
embryonic lethality prior to t... 2 | 187
enlarged lymph nodes 2 | 27
improved glucose tolerance 2 | 56
increased circulating choleste... 2 | 53
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
short tibia 2 | 82
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal eye anterior chamber ... 1 | 3
abnormal eye morphology 1 | 38
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
corneal vascularization 1 | 5
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
hypoactivity 1 | 89
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased mean platelet volume 1 | 19
limb grasping 1 | 35
premature death 1 | 5
small kidney 1 | 10
small spleen 1 | 11
small superior vagus ganglion 1 | 20
small testis 1 | 37
small thymus 1 | 11
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 151 | 8,484
osteosarcoma 147 | 7,933
glioblastoma 124 | 5,572
Cancer 123 | 2,346
psoriasis 123 | 6,685
medulloblastoma, large-cell 117 | 6,234
lung cancer 104 | 4,466
lung carcinoma 85 | 2,844
pilocytic astrocytoma 85 | 3,086
invasive ductal carcinoma 82 | 2,950
pancreatic cancer 81 | 2,300
atypical teratoid / rhabdoid tumor 79 | 4,369
malignant mesothelioma 78 | 3,162
lung adenocarcinoma 73 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
pediatric high grade glioma 68 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 65 | 2,956
interstitial cystitis 63 | 2,299
non-small cell lung cancer 63 | 2,798
subependymal giant cell astrocytoma 63 | 2,287
Breast cancer 61 | 3,094
ulcerative colitis 61 | 2,087
oligodendroglioma 58 | 2,849
diabetes mellitus 56 | 1,663
primitive neuroectodermal tumor 54 | 3,031
Carcinoma 50 | 2,147
ependymoma 50 | 2,514
tuberculosis 48 | 1,557
cystic fibrosis 47 | 1,665
astrocytoma 46 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,795
Rheumatoid Arthritis 41 | 1,160
breast carcinoma 41 | 1,614
ductal carcinoma in situ 41 | 1,745
primary pancreatic ductal adenocarcinoma 41 | 1,271
group 4 medulloblastoma 40 | 1,875
juvenile dermatomyositis 40 | 1,189
Pick disease 38 | 1,893
posterior fossa group A ependymoma 38 | 1,511
colon cancer 37 | 1,475
adult high grade glioma 35 | 2,148
astrocytic glioma 34 | 2,241
pituitary cancer 34 | 1,972
Kidney disease 32 | 396
group 3 medulloblastoma 32 | 2,254
primary Sjogren syndrome 32 | 789
pancreatic carcinoma 31 | 567
Asthma 29 | 349
Duchenne muscular dystrophy 29 | 602
Multiple myeloma 29 | 1,327
Obesity 29 | 616
adrenocortical carcinoma 29 | 1,427
Cerebrovascular disease 28 | 231
gastric carcinoma 28 | 832
medulloblastoma 28 | 1,524
Atherosclerosis 27 | 275
Vascular disease 27 | 281
esophageal adenocarcinoma 27 | 737
acute quadriplegic myopathy 26 | 1,157
cutaneous lupus erythematosus 26 | 1,056
Alzheimer's disease 25 | 644
Coronary artery disease 25 | 240
Thrombocytopenia 25 | 105
dermatomyositis 23 | 933
sonic hedgehog group medulloblastoma 23 | 1,482
Heart disease 22 | 279
Waldenstrons macroglobulinemia 22 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 499
Arthritis 21 | 248
Prostatic Neoplasms 21 | 471
active Crohn's disease 21 | 918
posterior fossa group B ependymoma 21 | 1,530
Mammary Neoplasms 20 | 410
mucosa-associated lymphoid tissue lymphoma 20 | 480
Hypertension 19 | 287
Neoplasm Invasiveness 19 | 127
spina bifida 19 | 1,064
Hypertensive disease 18 | 193
IGA Glomerulonephritis 18 | 454
atypical teratoid/rhabdoid tumor 18 | 1,095
Liver disease 17 | 219
fibroadenoma 17 | 557
Down syndrome 16 | 548
Hypersensitivity reaction type II disease 16 | 235
Liver Cirrhosis 16 | 101
Liver carcinoma 16 | 217
Lung disease 16 | 132
Osteoporosis 16 | 257
Peripheral vascular disease 16 | 90
Schizophrenia 16 | 501
Thrombophilia 16 | 36
gastric cancer 16 | 430
Anemia 15 | 252
Atopic dermatitis 15 | 944
Multiple Sclerosis 15 | 498
Parkinson's disease 15 | 364
Stomach Neoplasms 15 | 282
nasopharyngeal carcinoma 15 | 1,056
non-small cell lung carcinoma 15 | 413

Tissue

Liver and Pancreas 271 | 18,136
Nervous System 271 | 18,561
Urinary Tract 271 | 18,444
Blood and immune system 270 | 17,995
Digestive Tract 270 | 18,473
Female tissues 270 | 18,647
Endocrine System 269 | 18,512
Cardiovascular System 267 | 17,958
Male tissues 267 | 17,969
Respiratory system 266 | 17,484
Skin and soft tissues 266 | 18,115

Target Family

Non-IDG 170 | 11,971
Enzyme 52 | 4,146
Kinase 35 | 634
GPCR 9 | 406
Ion Channel 6 | 341
Epigenetic 1 | 242
Transporter 1 | 473

Reactome Pathway

Platelet activation, signaling... 274 | 274
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NHL repeat-containing protein 2 NHLRC2 Tdark Non-IDG 0.78 1.17 50
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Galectin-3-binding protein LGALS3BP Tbio Non-IDG -2.79457 669.7 172
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Platelet factor 4 PF4 Tbio Non-IDG -3.28845 2045.5 243
Platelet basic protein PPBP Tbio Non-IDG -3.18113 1540.1 348