Development Level

Tbio 21 | 11,651
Tchem 10 | 1,388
Tclin 1 | 612

IMPC Phenotype

increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased circulating HDL chol... 2 | 68
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating free fat... 2 | 20
increased circulating triglyce... 2 | 42
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cecum morphology 1 | 7
abnormal heart shape 1 | 5
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased cardiac muscle contr... 1 | 11
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged seminal vesicle 1 | 10
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased exploration in new e... 1 | 8
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 21 | 11,493
ovarian cancer 20 | 8,520
psoriasis 16 | 6,694
osteosarcoma 15 | 7,950
Atherosclerosis 13 | 291
invasive ductal carcinoma 11 | 2,951
lung cancer 11 | 4,740
medulloblastoma, large-cell 11 | 6,241
diabetes mellitus 10 | 1,728
Autosomal recessive predisposition 9 | 1,442
Coronary artery disease 9 | 268
Kidney cancer 9 | 2,613
Lipid metabolism disorder 9 | 114
Obesity 9 | 678
adrenocortical carcinoma 9 | 1,428
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
ductal carcinoma in situ 8 | 1,745
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
subependymal giant cell astrocytoma 8 | 2,287
Breast cancer 7 | 3,578
Cardiovascular system disease 7 | 246
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
oligodendroglioma 7 | 2,850
Hepatomegaly 6 | 285
Hypercholesterolemia 6 | 44
Hypercholesterolemia, Familial 6 | 23
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
Alzheimer's disease 5 | 658
Hyperlipidemia 5 | 43
Hyperlipoproteinemia Type IIa 5 | 11
Hypertensive disease 5 | 292
Serum cholesterol raised 5 | 22
Splenomegaly 5 | 190
active Crohn's disease 5 | 922
astrocytic glioma 5 | 2,597
esophageal adenocarcinoma 5 | 737
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Angina Pectoris 4 | 32
Arcus Senilis 4 | 11
Astrocytoma, Pilocytic 4 | 3,081
Cerebellar Ataxia 4 | 304
Cerebrovascular disease 4 | 238
Cognitive delay 4 | 608
Coronary artery disease, premature 4 | 6
Dementia 4 | 175
Down syndrome 4 | 499
Familial hypercholesterolemia - homozygous 4 | 7
Global developmental delay 4 | 608
Heart disease 4 | 306
Hyperlipidemias 4 | 17
Hyperlipoproteinemia Type II 4 | 12
Increase in blood pressure 4 | 119
Kidney disease 4 | 430
Low density lipoprotein increased 4 | 8
Mental and motor retardation 4 | 608
Multiple myeloma 4 | 1,332
Myocardial Infarction 4 | 151
Seizures 4 | 596
Steatohepatitis 4 | 44
Vascular disease 4 | 319
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
lung carcinoma 4 | 2,843
primitive neuroectodermal tumor 4 | 3,035
Anemia 3 | 365
Arcus juvenilis 3 | 5
Cancer 3 | 2,499
Chemical and Drug Induced Liver Injury 3 | 195
Cholestasis 3 | 155
Coronary Disease 3 | 25
Coronary heart disease 3 | 16
Duchenne muscular dystrophy 3 | 601
Dysarthria 3 | 192
Epilepsy 3 | 792
Hypertension 3 | 396
Liver cancer 3 | 604
Liver disease 3 | 237
Metabolic syndrome X 3 | 52
Neurodegenerative disease 3 | 414
Proteinuria 3 | 144
Sudden Cardiac Death 3 | 29
Type 2 diabetes mellitus 3 | 272
active ulcerative colitis 3 | 764
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non-small cell lung cancer 3 | 2,890
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 416
spina bifida 3 | 1,074

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Respiratory system 31 | 16,393
Cardiovascular System 30 | 15,192
Nervous System 30 | 16,725

Target Family

Non-IDG 22 | 12,091
Enzyme 8 | 4,145
Nuclear Receptor 2 | 48

Reactome Pathway

Plasma lipoprotein clearance 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.05580 115.6 135
Lipolysis-stimulated lipoprotein receptor LSR Tbio Non-IDG -1.92670 81.8 89
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
AP-2 complex subunit alpha-1 AP2A1 Tbio Non-IDG -0.60535 3.75 186
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Very low-density lipoprotein receptor VLDLR Tbio Non-IDG -2.41777 260.3 283
Apolipoprotein A-I APOA1 Tbio Non-IDG -3.62534 3592.8 1151