Development Level

Tbio 45 | 11,445
Tchem 21 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased circulating HDL chol... 4 | 68
increased circulating choleste... 4 | 66
abnormal seminal vesicle morph... 3 | 114
decreased circulating choleste... 3 | 93
decreased vertical activity 3 | 208
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal facial morphology 1 | 17
abnormal heart shape 1 | 5
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
absent optic nerve 1 | 2
absent pinna reflex 1 | 23
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased granulocyte number 1 | 6
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
enlarged cecum 1 | 5
enlarged seminal vesicle 1 | 10
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 45 | 11,493
ovarian cancer 35 | 8,520
psoriasis 34 | 6,694
osteosarcoma 31 | 7,950
Atherosclerosis 30 | 291
Lipid metabolism disorder 27 | 114
diabetes mellitus 27 | 1,728
Coronary artery disease 24 | 268
Obesity 22 | 678
medulloblastoma, large-cell 22 | 6,241
glioblastoma 21 | 5,792
invasive ductal carcinoma 21 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
lung cancer 20 | 4,740
Autosomal recessive predisposition 19 | 1,442
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 19 | 3,232
ductal carcinoma in situ 17 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Cardiovascular system disease 14 | 246
ependymoma 14 | 4,679
pancreatic cancer 14 | 2,398
Breast cancer 13 | 3,578
Hypercholesterolemia, Familial 13 | 23
Kidney cancer 13 | 2,613
adrenocortical carcinoma 13 | 1,428
group 3 medulloblastoma 13 | 4,104
oligodendroglioma 13 | 2,850
subependymal giant cell astrocytoma 13 | 2,287
Astrocytoma, Pilocytic 12 | 3,081
breast carcinoma 12 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
tuberculosis 12 | 2,010
Hypercholesterolemia 11 | 44
adult high grade glioma 11 | 3,801
lung carcinoma 11 | 2,843
Hyperlipidemia 10 | 43
Hyperlipoproteinemia Type II 10 | 12
active Crohn's disease 10 | 922
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Cancer 9 | 2,499
Down syndrome 9 | 499
Hypertensive disease 9 | 292
Kidney disease 9 | 430
astrocytic glioma 9 | 2,597
primitive neuroectodermal tumor 9 | 3,035
ulcerative colitis 9 | 1,819
Alzheimer's disease 8 | 658
Anemia 8 | 365
Cerebrovascular disease 8 | 238
Hepatomegaly 8 | 285
Hypertension 8 | 396
Liver Cirrhosis, Experimental 8 | 769
Serum cholesterol raised 8 | 22
Splenomegaly 8 | 190
acute quadriplegic myopathy 8 | 1,158
cystic fibrosis 8 | 1,696
non-small cell lung cancer 8 | 2,890
Amyloidosis 7 | 67
Arcus Senilis 7 | 11
Cardiovascular Diseases 7 | 59
Dyslipidemias 7 | 27
Fatty liver disease 7 | 103
Hyperlipoproteinemia Type IIa 7 | 11
Hypertriglyceridemia 7 | 17
Pancreatitis 7 | 123
Vascular disease 7 | 319
astrocytoma 7 | 1,146
interstitial cystitis 7 | 2,312
pediatric high grade glioma 7 | 1,064
pituitary cancer 7 | 1,972
Duchenne muscular dystrophy 6 | 601
Fatty Liver 6 | 70
Heart disease 6 | 306
Hyperlipidemias 6 | 17
Hypertriglyceridemia result 6 | 37
Metabolic syndrome X 6 | 52
Multiple myeloma 6 | 1,332
Myocardial Infarction 6 | 151
Proteinuria 6 | 144
Schizophrenia 6 | 1,160
Type 2 diabetes mellitus 6 | 272
active ulcerative colitis 6 | 764
fibroadenoma 6 | 559
group 4 medulloblastoma 6 | 1,855
Atopic dermatitis 5 | 952
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Epilepsy 5 | 792
Mental and motor retardation 5 | 608
Seizures 5 | 596
cutaneous lupus erythematosus 5 | 1,057
esophageal adenocarcinoma 5 | 737
juvenile dermatomyositis 5 | 1,187
nasopharyngeal carcinoma 5 | 1,058
nephrosclerosis 5 | 333
pancreatic carcinoma 5 | 562
posterior fossa group B ependymoma 5 | 416
spina bifida 5 | 1,074

Tissue

Endocrine System 69 | 18,159
Liver and Pancreas 69 | 16,750
Digestive Tract 68 | 17,369
Female tissues 67 | 17,400
Urinary Tract 67 | 16,678
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Blood and immune system 65 | 16,909
Nervous System 62 | 16,725
Respiratory system 62 | 16,393
Cardiovascular System 57 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 22 | 4,145
Kinase 3 | 634
Nuclear Receptor 2 | 48
Transporter 2 | 473
Transcription Factor 1 | 1,400

Reactome Pathway

Plasma lipoprotein assembly, r... 70 | 70
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Lipase maturation factor 1 LMF1 Tbio Enzyme -1.30021 24.5 35
Probable palmitoyltransferase ZDHHC8 ZDHHC8 Tbio Enzyme -1.30633 19.3 116
Lipase maturation factor 2 LMF2 Tdark Enzyme -0.22185 1.90 91
Vigilin HDLBP Tbio Non-IDG -2.01228 106.9 233
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Serum albumin ALB Tchem Non-IDG -5.01233 98804.9 2101
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Apolipoprotein B receptor APOBR Tbio Non-IDG -1.00933 12.4 135