Development Level

Tbio 130 | 11,178
Tchem 52 | 1,885
Tdark 22 | 6,569
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 11 | 499
cataract 5 | 92
embryonic lethality prior to o... 5 | 239
abnormal embryo size 4 | 220
abnormal lens morphology 4 | 81
decreased total body fat amoun... 4 | 207
hyperactivity 4 | 148
abnormal behavior 3 | 298
abnormal epididymis morphology 3 | 42
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating aspartat... 3 | 34
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
enlarged epididymis 3 | 31
increased lean body mass 3 | 172
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased circulating alanine ... 2 | 47
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lactate dehydrogenas... 2 | 16
decreased mean corpuscular hem... 2 | 50
decreased vertical activity 2 | 208
edema 2 | 59
enlarged lymph nodes 2 | 37
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
persistence of hyaloid vascula... 2 | 33
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 148 | 11,192
ovarian cancer 113 | 8,297
osteosarcoma 109 | 7,766
medulloblastoma, large-cell 88 | 6,086
psoriasis 77 | 6,514
glioblastoma 72 | 5,635
ependymoma 69 | 4,559
atypical teratoid / rhabdoid tumor 68 | 4,971
adult high grade glioma 54 | 3,701
lung cancer 54 | 4,607
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,204
invasive ductal carcinoma 48 | 2,867
group 3 medulloblastoma 46 | 4,002
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,872
oligodendroglioma 46 | 2,768
Breast cancer 41 | 3,469
Astrocytoma, Pilocytic 40 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,902
astrocytic glioma 38 | 2,530
lung carcinoma 38 | 2,755
Kidney cancer 37 | 2,548
non-small cell lung cancer 36 | 2,799
primitive neuroectodermal tumor 36 | 2,957
interstitial cystitis 34 | 2,237
subependymal giant cell astrocytoma 34 | 2,230
group 4 medulloblastoma 33 | 1,806
pancreatic cancer 33 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,911
lung adenocarcinoma 30 | 2,627
ulcerative colitis 29 | 1,765
malignant mesothelioma 28 | 3,135
Pick disease 27 | 1,856
pituitary cancer 27 | 1,915
diabetes mellitus 25 | 1,683
ductal carcinoma in situ 25 | 1,686
Autosomal recessive predisposition 24 | 1,407
tuberculosis 22 | 1,963
Schizophrenia 21 | 1,136
breast carcinoma 21 | 1,589
juvenile dermatomyositis 21 | 1,147
Cancer 19 | 2,388
active Crohn's disease 18 | 882
Intellectual disability 17 | 998
colon cancer 17 | 1,428
spina bifida 17 | 1,053
Rheumatoid arthritis 16 | 1,156
acute quadriplegic myopathy 16 | 1,133
dermatomyositis 15 | 941
primary pancreatic ductal adenocarcinoma 15 | 1,071
cutaneous lupus erythematosus 14 | 1,016
nasopharyngeal carcinoma 14 | 1,024
non primary Sjogren syndrome sicca 14 | 861
Centronuclear myopathy 13 | 27
Multiple myeloma 13 | 1,296
Waldenstrons macroglobulinemia 13 | 742
adrenocortical carcinoma 13 | 1,385
astrocytoma 13 | 1,113
cystic fibrosis 13 | 1,629
Muscle hypotonia 12 | 562
Obesity 12 | 655
active ulcerative colitis 12 | 736
aldosterone-producing adenoma 12 | 646
gastric carcinoma 12 | 781
pancreatic carcinoma 12 | 555
primary Sjogren syndrome 12 | 710
Dull intelligence 11 | 634
Low intelligence 11 | 634
Mental Retardation 11 | 634
Mental deficiency 11 | 634
Neurodegenerative disease 11 | 402
Neuropathy 11 | 254
Poor school performance 11 | 634
Seizures 11 | 584
esophageal adenocarcinoma 11 | 696
pediatric high grade glioma 11 | 1,035
Alzheimer's disease 10 | 640
Bipolar Disorder 10 | 646
Liver Cirrhosis, Experimental 10 | 733
Oculocerebrorenal syndrome 10 | 29
Acquired scoliosis 9 | 274
Amyotrophic lateral sclerosis 9 | 437
Curvature of spine 9 | 275
Epilepsy 9 | 775
Failure to gain weight 9 | 359
Melanoma 9 | 689
Pediatric failure to thrive 9 | 359
Sengers syndrome 9 | 18
Toxic encephalopathy 9 | 139
progressive supranuclear palsy 9 | 656
Cataract 8 | 290
Cognitive delay 8 | 596
Global developmental delay 8 | 596
Hypoplastic mandible condyle 8 | 273
Liver cancer 8 | 589
Mandibular hypoplasia 8 | 273
Mental and motor retardation 8 | 596
Micrognathism 8 | 273
acute myeloid leukemia 8 | 760
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 492
fibroadenoma 8 | 538

Tissue

Female tissues 207 | 17,400
Digestive Tract 206 | 17,369
Endocrine System 205 | 18,159
Skin and soft tissues 205 | 17,230
Blood and immune system 204 | 16,909
Male tissues 203 | 17,142
Urinary Tract 201 | 16,678
Liver and Pancreas 200 | 16,750
Nervous System 200 | 16,725
Respiratory system 198 | 16,393
Cardiovascular System 194 | 15,192

Target Family

Enzyme 133 | 4,145
Non-IDG 43 | 12,091
Kinase 28 | 634
Transporter 5 | 473

Reactome Pathway

Phospholipid metabolism 209 | 209
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Membrane-associated phosphatidylinositol transfer protein 1 PITPNM1 Tbio Non-IDG -1.99576 100.1 173
Phosphatidylethanolamine N-methyltransferase PEMT Tbio Enzyme -1.90213 89.9 149
Phosphatidylinositol 4-kinase beta PI4KB Tchem Kinase -1.85524 71.3 104
Phospholipase D1 PLD1 Tchem Enzyme -1.51188 30.9 203
Phosphatidylinositide phosphatase SAC1 SACM1L Tbio Enzyme -2.04383 109.7 89
Pleckstrin homology domain-containing family A member 5 PLEKHA5 Tdark Non-IDG -0.62123 4.21 55
Phosphatidylinositide phosphatase SAC2 INPP5F Tbio Enzyme -0.71120 5.56 89
Phosphatidate phosphatase LPIN1 LPIN1 Tbio Enzyme -2.13963 149.5 280
Pleckstrin homology domain-containing family A member 6 PLEKHA6 Tdark Non-IDG -0.18435 1.27 103