Development Level

Tbio 119 | 10,625
Tchem 52 | 1,890
Tdark 27 | 7,003
Tclin 4 | 602

Collection

Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 9 | 633
decreased body weight 3 | 174
decreased circulating alanine ... 3 | 53
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
increased mean corpuscular hem... 3 | 93
preweaning lethality, incomple... 3 | 260
abnormal QRS complex 2 | 25
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
abnormal lens morphology 2 | 73
abnormal spleen morphology 2 | 36
decreased bone mineral content 2 | 157
decreased circulating aspartat... 2 | 27
decreased circulating calcium ... 2 | 33
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased lean body mass 2 | 195
enlarged epididymis 2 | 27
enlarged lymph nodes 2 | 27
hyperactivity 2 | 108
increased body weight 2 | 42
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased lean body mass 2 | 107
increased red blood cell distr... 2 | 21
abnormal coat appearance 1 | 25
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal vocalization 1 | 21
absent heartbeat 1 | 6
decreased B cell number 1 | 30
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased circulating iron lev... 1 | 25
decreased circulating lactate ... 1 | 1
decreased circulating potassiu... 1 | 17
decreased circulating thyroxin... 1 | 5
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
embryonic lethality prior to t... 1 | 187
hydrometra 1 | 13
hypoactivity 1 | 89
immune system phenotype 1 | 17
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate variabili... 1 | 4
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
small seminal vesicle 1 | 6
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 108 | 8,484
osteosarcoma 107 | 7,933
medulloblastoma, large-cell 78 | 6,234
psoriasis 78 | 6,685
glioblastoma 64 | 5,572
atypical teratoid / rhabdoid tumor 56 | 4,369
lung cancer 54 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
invasive ductal carcinoma 44 | 2,950
oligodendroglioma 43 | 2,849
ependymoma 41 | 2,514
pilocytic astrocytoma 41 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
lung carcinoma 38 | 2,844
Breast cancer 36 | 3,094
interstitial cystitis 35 | 2,299
non-small cell lung cancer 35 | 2,798
primitive neuroectodermal tumor 35 | 3,031
ulcerative colitis 34 | 2,087
subependymal giant cell astrocytoma 33 | 2,287
adult high grade glioma 31 | 2,148
astrocytic glioma 31 | 2,241
pancreatic cancer 31 | 2,300
pediatric high grade glioma 31 | 2,712
lung adenocarcinoma 30 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,795
malignant mesothelioma 29 | 3,162
group 4 medulloblastoma 28 | 1,875
pituitary cancer 27 | 1,972
Pick disease 26 | 1,893
diabetes mellitus 24 | 1,663
ductal carcinoma in situ 24 | 1,745
Carcinoma 22 | 2,147
group 3 medulloblastoma 21 | 2,254
sonic hedgehog group medulloblastoma 21 | 1,482
breast carcinoma 20 | 1,614
juvenile dermatomyositis 20 | 1,189
Cancer 19 | 2,346
active Crohn's disease 17 | 918
astrocytoma 17 | 1,493
posterior fossa group A ependymoma 17 | 1,511
spina bifida 17 | 1,064
tuberculosis 17 | 1,557
Rheumatoid Arthritis 16 | 1,160
colon cancer 16 | 1,475
dermatomyositis 16 | 933
medulloblastoma 16 | 1,524
acute quadriplegic myopathy 15 | 1,157
cystic fibrosis 15 | 1,665
primary pancreatic ductal adenocarcinoma 15 | 1,271
cutaneous lupus erythematosus 14 | 1,056
nasopharyngeal carcinoma 14 | 1,056
Multiple myeloma 13 | 1,327
Waldenstrons macroglobulinemia 13 | 765
adrenocortical carcinoma 13 | 1,427
gastric carcinoma 13 | 832
posterior fossa group B ependymoma 13 | 1,530
non primary Sjogren syndrome sicca 12 | 840
pancreatic carcinoma 12 | 567
primary Sjogren syndrome 12 | 789
aldosterone-producing adenoma 11 | 664
esophageal adenocarcinoma 11 | 737
Alzheimer's disease 10 | 644
Intellectual disability 10 | 573
atypical teratoid/rhabdoid tumor 10 | 1,095
fibroadenoma 10 | 557
Centronuclear myopathy 9 | 21
Neurodegenerative disease 9 | 383
Oculocerebrorenal syndrome 9 | 23
Toxic encephalopathy 9 | 131
progressive supranuclear palsy 9 | 674
Amyotrophic Lateral Sclerosis 8 | 431
Schizophrenia 8 | 501
Sengers syndrome 8 | 17
acute myeloid leukemia 8 | 780
Duchenne muscular dystrophy 7 | 602
Mammary Neoplasms 7 | 410
Obesity 7 | 616
Parkinson's disease 7 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
tuberculosis and treatment for 6 months 7 | 686
Atopic dermatitis 6 | 944
Barth syndrome 6 | 23
Fatty liver disease 6 | 84
IGA Glomerulonephritis 6 | 454
Neuropathy 6 | 210
Prostatic Neoplasms 6 | 471
active ulcerative colitis 6 | 477
glioblastoma multiforme 6 | 347
nephrosclerosis 6 | 329
Chronic Lymphocytic Leukemia 5 | 242
Down syndrome 5 | 548
Lipodystrophy 5 | 32
Liver disease 5 | 219
Neutral lipid storage disease 5 | 14
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
Peripheral Neuropathy 4 | 303
hepatocellular carcinoma 4 | 532

Tissue

Digestive Tract 200 | 18,473
Female tissues 200 | 18,647
Nervous System 200 | 18,561
Urinary Tract 200 | 18,444
Endocrine System 199 | 18,512
Blood and immune system 198 | 17,995
Cardiovascular System 198 | 17,958
Skin and soft tissues 198 | 18,115
Liver and Pancreas 197 | 18,136
Male tissues 197 | 17,969
Respiratory system 196 | 17,484

Target Family

Enzyme 133 | 4,146
Non-IDG 36 | 11,971
Kinase 28 | 634
Transporter 5 | 473

Reactome Pathway

Phospholipid metabolism 202 | 202
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Phosphatidylserine synthase 2 PTDSS2 Tbio Enzyme -0.74689 6.34 68
Choline dehydrogenase, mitochondrial CHDH Tbio Enzyme -1.38953 24.8 68
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.11277 1238.0 122
Phospholipase A1 member A PLA1A Tbio Enzyme -1.76413 56.8 115
Choline transporter-like protein 2 SLC44A2 Tbio Transporter -1.57202 38.4 77