Development Level

Tbio 48 | 11,445
Tchem 36 | 1,598
Tclin 18 | 613
Tdark 3 | 6,588

IMPC Phenotype

increased startle reflex 4 | 112
abnormal behavior 3 | 298
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal vocalization 2 | 21
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
small kidney 2 | 16
abnormal bone mineralization 1 | 38
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal hair growth 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal male genitalia morpho... 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal startle reflex 1 | 15
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased skeletal muscle mass 1 | 1
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased caudal vertebrae num... 1 | 7
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
male infertility 1 | 123
polydactyly 1 | 7
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 83 | 11,493
psoriasis 56 | 6,694
ovarian cancer 44 | 8,520
osteosarcoma 39 | 7,950
lung cancer 38 | 4,740
Cancer 36 | 2,499
medulloblastoma, large-cell 35 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
interstitial cystitis 27 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
lung carcinoma 26 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
non-small cell lung cancer 25 | 2,890
atypical teratoid / rhabdoid tumor 24 | 5,112
glioblastoma 22 | 5,792
invasive ductal carcinoma 22 | 2,951
lung adenocarcinoma 22 | 2,716
Breast cancer 21 | 3,578
Prostatic Neoplasms 20 | 495
ductal carcinoma in situ 20 | 1,745
group 3 medulloblastoma 20 | 4,104
malignant mesothelioma 20 | 3,232
Autosomal recessive predisposition 18 | 1,442
adult high grade glioma 18 | 3,801
ependymoma 18 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
pituitary cancer 18 | 1,972
Alcoholic Intoxication, Chronic 17 | 289
ulcerative colitis 17 | 1,819
Liver disease 16 | 237
adrenocortical carcinoma 16 | 1,428
Hypertension 15 | 396
cystic fibrosis 15 | 1,696
Alcohol dependence 14 | 107
Schizophrenia 14 | 1,160
pancreatic cancer 14 | 2,398
tuberculosis 14 | 2,010
Chemical and Drug Induced Liver Injury 13 | 195
Liver Cirrhosis, Experimental 13 | 769
breast carcinoma 13 | 1,638
diabetes mellitus 13 | 1,728
Astrocytoma, Pilocytic 12 | 3,081
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Congenital adrenal hyperplasia 11 | 73
Hypertensive disease 11 | 292
chronic rhinosinusitis 11 | 512
colon cancer 11 | 1,478
esophageal adenocarcinoma 11 | 737
Alcohol abuse 10 | 50
Endometriosis 10 | 540
Obesity 10 | 678
active Crohn's disease 10 | 922
oligodendroglioma 10 | 2,850
Cholestasis 9 | 155
Depressive disorder 9 | 409
Osteoporosis 9 | 363
aldosterone-producing adenoma 9 | 665
fibroadenoma 9 | 559
nasopharyngeal carcinoma 9 | 1,058
nephrosclerosis 9 | 333
substance-related disorder 9 | 162
Lung Neoplasms 8 | 232
cutaneous lupus erythematosus 8 | 1,057
primitive neuroectodermal tumor 8 | 3,035
Adenoma 7 | 167
Atopic dermatitis 7 | 952
Cushing's syndrome 7 | 48
Epilepsy 7 | 792
Kidney cancer 7 | 2,613
Melanoma 7 | 711
Pick disease 7 | 1,894
Rheumatoid arthritis 7 | 1,191
acute quadriplegic myopathy 7 | 1,158
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
group 4 medulloblastoma 7 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 7 | 239
Cardiomegaly 6 | 116
Colorectal Neoplasms 6 | 243
Drug-Related Side Effects and Adverse Reactions 6 | 62
Esophageal Neoplasms 6 | 69
Failure to gain weight 6 | 365
Gynecomastia 6 | 64
Hepatomegaly 6 | 285
Hypotension 6 | 82
Increase in blood pressure 6 | 119
Major Depressive Disorder 6 | 301
Male infertility 6 | 206
Pediatric failure to thrive 6 | 365
Polycystic ovary syndrome 6 | 360
Substance abuse 6 | 59
adrenocortical adenoma 6 | 131
head and neck cancer 6 | 271
medulloblastoma 6 | 720
subependymal giant cell astrocytoma 6 | 2,287
Bipolar Disorder 5 | 666
acute myeloid leukemia 5 | 783
gastric carcinoma 5 | 807
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Digestive Tract 101 | 17,369
Endocrine System 101 | 18,159
Female tissues 100 | 17,400
Liver and Pancreas 99 | 16,750
Skin and soft tissues 98 | 17,230
Male tissues 97 | 17,142
Urinary Tract 95 | 16,678
Blood and immune system 94 | 16,909
Respiratory system 94 | 16,393
Nervous System 87 | 16,725
Cardiovascular System 74 | 15,192

Target Family

Enzyme 62 | 4,145
Non-IDG 36 | 12,091
Transcription Factor 4 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

Reactome Pathway

Phase I - Functionalization of... 105 | 105
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.68768 52.8 77
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 Tbio Enzyme -1.48800 26.8 73
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.85150 6.83 4
Cytochrome P450 11B1, mitochondrial CYP11B1 Tclin Enzyme -2.66308 432.9 136
Alcohol dehydrogenase class 4 mu/sigma chain ADH7 Tchem Enzyme -2.18765 159.0 243
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252