Development Level

Tbio 19 | 11,445
Tclin 14 | 613
Tchem 5 | 1,598
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 17 | 99

IMPC Phenotype

decreased circulating glucose ... 2 | 126
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal placenta vasculature 1 | 2
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
cyanosis 1 | 7
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
edema 1 | 59
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased circulating sodium l... 1 | 71
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2

Disease

Carcinoma 33 | 11,493
medulloblastoma, large-cell 27 | 6,241
glioblastoma 26 | 5,792
adult high grade glioma 25 | 3,801
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 23 | 4,679
Astrocytoma, Pilocytic 22 | 3,081
osteosarcoma 22 | 7,950
primitive neuroectodermal tumor 19 | 3,035
oligodendroglioma 18 | 2,850
group 3 medulloblastoma 17 | 4,104
ovarian cancer 17 | 8,520
psoriasis 17 | 6,694
Epilepsy 16 | 792
Kidney cancer 16 | 2,613
lung carcinoma 15 | 2,843
astrocytic glioma 13 | 2,597
Pick disease 12 | 1,894
lung cancer 12 | 4,740
Breast cancer 11 | 3,578
pituitary cancer 11 | 1,972
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 27
malignant mesothelioma 10 | 3,232
subependymal giant cell astrocytoma 10 | 2,287
Postherpetic neuralgia 9 | 11
Skin cancer 9 | 469
lung adenocarcinoma 9 | 2,716
Anesthesia for cesarean section 8 | 8
Atrial Fibrillation 8 | 124
Bipolar disorder in remission 8 | 19
Brugada syndrome 8 | 29
Cerebellar Ataxia 8 | 304
Major Nerve Block for Surgery 8 | 8
Melanoma 8 | 711
Regional Anesthesia for Labor Pain 8 | 9
Regional Anesthesia for Postoperative Pain 8 | 9
Regional Anesthesia for Surgery 8 | 9
Simple partial seizure 8 | 26
Tonic-clonic seizure 8 | 11
invasive ductal carcinoma 8 | 2,951
Administration of Local Anesthetic Nerve Block 7 | 14
Administration of Regional Anesthesia 7 | 7
Bipolar Disorder 7 | 666
Local Anesthesia for Ophthalmologic Procedure 7 | 7
Local anesthesia, by infiltration 7 | 14
Local anesthetic intrathecal block 7 | 7
Neuralgia 7 | 20
Premature ejaculation 7 | 16
Prevention of Seizures following Cranial Trauma or Surgery 7 | 7
Seizures in Neurosurgery 7 | 7
Status Epilepticus 7 | 98
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Administration of Corneal Anesthesia 6 | 6
Brugada Syndrome (disorder) 6 | 15
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hemorrhoids 6 | 13
Infestation by Phthirus pubis 6 | 7
Infestation by Sarcoptes scabiei var hominis 6 | 7
Liver cancer 6 | 604
Local Anesthesia for Endotracheal Intubation 6 | 6
Local Anesthesia for Urethral Pain 6 | 6
Mental and motor retardation 6 | 608
Pediculosis capitis 6 | 7
Pruritus ani 6 | 14
Regional Anesthesia for Ophthalmologic Surgery 6 | 6
Schizophrenia 6 | 1,160
Seizures 6 | 596
Tremor 6 | 113
Urethritis 6 | 10
colon cancer 6 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Endometrial cancer 5 | 311
Familial atrial fibrillation 5 | 23
Muscle hypotonia 5 | 571
Parkinsonism 5 | 18
Spasticity 5 | 26
non-small cell lung cancer 5 | 2,890

Tissue

Endocrine System 42 | 18,159
Nervous System 40 | 16,725
Digestive Tract 38 | 17,369
Blood and immune system 37 | 16,909
Female tissues 37 | 17,400
Male tissues 37 | 17,142
Skin and soft tissues 36 | 17,230
Respiratory system 35 | 16,393
Urinary Tract 35 | 16,678
Liver and Pancreas 33 | 16,750
Cardiovascular System 27 | 15,192

Target Family

Ion Channel 33 | 344
Kinase 4 | 634
Non-IDG 4 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Phase 0 - rapid depolarisation 42 | 42
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Sodium channel protein type 3 subunit alpha SCN3A Tclin Ion Channel -1.98160 87.0 76
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.46568 276.3 60
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tbio Ion Channel -1.46356 25.4 471
Sodium channel subunit beta-4 SCN4B Tbio Ion Channel -1.42029 24.1 85
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Sodium channel protein type 8 subunit alpha SCN8A Tclin Ion Channel -2.54867 340.7 156
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tdark Ion Channel -0.50762 2.36 68