Development Level

Tbio 47 | 11,445
Tchem 13 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased circulating choleste... 2 | 93
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal maxilla morphology 1 | 17
abnormal skin morphology 1 | 50
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased circulating amylase ... 1 | 25
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 38 | 11,493
ovarian cancer 36 | 8,520
psoriasis 27 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Autosomal recessive predisposition 21 | 1,442
osteosarcoma 21 | 7,950
Zellweger syndrome 20 | 37
glioblastoma 17 | 5,792
medulloblastoma, large-cell 17 | 6,241
Failure to gain weight 16 | 365
Muscle hypotonia 16 | 571
Pediatric failure to thrive 16 | 365
Seizures 16 | 596
Short stature 15 | 531
malignant mesothelioma 15 | 3,232
Chondrodysplasia punctata 14 | 41
Cognitive delay 14 | 608
Epilepsy 14 | 792
Global developmental delay 14 | 608
Hepatomegaly 14 | 285
Infantile Refsum disease 14 | 23
Mental and motor retardation 14 | 608
Nystagmus 14 | 317
Peroxisomal disease 14 | 22
lung cancer 14 | 4,740
Cataract 13 | 297
Cerebellar Ataxia 13 | 304
Concave bridge of nose 13 | 195
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Hypoplastic mandible condyle 13 | 275
Low Vision 13 | 174
Mandibular hypoplasia 13 | 275
Micrognathism 13 | 275
Retinitis Pigmentosa 13 | 226
Sensorineural Hearing Loss (disorder) 13 | 284
Visual Impairment 13 | 174
Abnormality of metabolism/homeostasis 12 | 134
Developmental regression 12 | 95
Lens Opacities 12 | 231
Loss of developmental milestones 12 | 95
Mental deterioration in childhood 12 | 95
Muscle Spasticity 12 | 195
Neurodevelopmental regression 12 | 95
Psychomotor regression 12 | 95
Psychomotor regression beginning in infancy 12 | 95
Psychomotor regression in infants 12 | 95
Psychomotor regression, progressive 12 | 95
ependymoma 12 | 4,679
Abnormal skeletal development 11 | 60
Abnormality of retinal pigmentation 11 | 111
Blepharoptosis 11 | 231
Broad flat nasal bridge 11 | 236
Byzanthine arch palate 11 | 194
Congenital Epicanthus 11 | 177
Difficulties with night vision 11 | 87
Elevated levels of phytanic acid 11 | 15
High forehead 11 | 102
Liver diseases 11 | 87
Nasal bridge wide 11 | 236
Night Blindness 11 | 101
Optic Atrophy 11 | 242
Osteochondrodysplasias 11 | 72
Respiratory Insufficiency 11 | 132
Respiratory function loss 11 | 121
Retinal pigment epithelial abnormality 11 | 111
Small head 11 | 374
Stippled epiphyses 11 | 28
Strabismus 11 | 270
Tall forehead 11 | 102
Upward slant of palpebral fissure 11 | 75
atypical teratoid / rhabdoid tumor 11 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
ulcerative colitis 11 | 1,819
Addison Disease 10 | 18
Adrenal cortical hypofunction 10 | 23
Adrenoleukodystrophy 10 | 29
Anteverted nostril 10 | 191
Big calvaria 10 | 147
Death in early childhood 10 | 82
Death in infancy 10 | 82
Electroencephalogram abnormal 10 | 101
Feeding difficulties in infancy 10 | 175
Flat face 10 | 52
Global developmental delay, severe 10 | 47
Hyperreflexia 10 | 209
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Liver Failure 10 | 73
Long narrow head 10 | 75
Narrow cranium shape 10 | 75
Narrow head shape 10 | 75
Narrow skull shape 10 | 75
Polymicrogyria 10 | 48
Premature Birth 10 | 77
Severe psychomotor retardation 10 | 47
Turridolichocephaly 10 | 75
astrocytic glioma 10 | 2,597
invasive ductal carcinoma 10 | 2,951

Tissue

Liver and Pancreas 62 | 16,750
Urinary Tract 62 | 16,678
Blood and immune system 61 | 16,909
Digestive Tract 61 | 17,369
Endocrine System 61 | 18,159
Skin and soft tissues 61 | 17,230
Female tissues 60 | 17,400
Nervous System 60 | 16,725
Male tissues 59 | 17,142
Respiratory system 59 | 16,393
Cardiovascular System 56 | 15,192

Target Family

Enzyme 40 | 4,145
Non-IDG 21 | 12,091
Transporter 1 | 473

Reactome Pathway

Peroxisomal protein import 62 | 62
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 4 DHRS4 Tbio Enzyme -1.65486 46.6 122
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100
Malonyl-CoA decarboxylase, mitochondrial MLYCD Tchem Enzyme -1.70434 46.1 67
Acyl-coenzyme A thioesterase 4 ACOT4 Tbio Enzyme -0.53787 2.87 58
Peroxisomal targeting signal 1 receptor PEX5 Tbio Non-IDG -2.43126 272.8 138
Peroxisome biogenesis factor 1 PEX1 Tbio Enzyme -0.77059 5.43 107
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Nucleoside diphosphate-linked moiety X motif 19 NUDT19 Tdark Non-IDG 0.90 0.09 79