Development Level

Tbio 86 | 11,445
Tchem 68 | 1,598
Tclin 31 | 613
Tdark 3 | 6,588

Collection

GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

prolonged QT interval 7 | 38
prolonged ST segment 7 | 36
decreased vertical activity 6 | 208
abnormal behavior 5 | 298
decreased bone mineral content 5 | 151
hypoactivity 5 | 132
preweaning lethality, complete... 5 | 979
abnormal kidney morphology 4 | 65
decreased circulating insulin ... 3 | 76
decreased neutrophil cell numb... 3 | 42
enlarged heart 3 | 210
increased bone mineral content 3 | 108
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
absent testes 2 | 6
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased lean body mass 2 | 135
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating calcium ... 2 | 34
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
prolonged RR interval 2 | 8
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal colon morphology 1 | 3
abnormal gait 1 | 69
abnormal ileum morphology 1 | 2
abnormal liver morphology 1 | 17
abnormal ovary morphology 1 | 7
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
absent epididymis 1 | 3
absent ovary 1 | 3
absent seminal vesicle 1 | 4
absent uterus 1 | 1
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating lipase l... 1 | 3
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
male infertility 1 | 123
polycystic kidney 1 | 15
premature death 1 | 5
shortened QRS complex duration 1 | 1
small kidney 1 | 16
small testis 1 | 58
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Carcinoma 96 | 11,493
psoriasis 82 | 6,694
Cancer 68 | 2,499
ovarian cancer 60 | 8,520
osteosarcoma 56 | 7,950
glioblastoma 52 | 5,792
lung cancer 51 | 4,740
medulloblastoma, large-cell 51 | 6,241
ependymoma 49 | 4,679
interstitial cystitis 46 | 2,312
Obesity 44 | 678
atypical teratoid / rhabdoid tumor 44 | 5,112
malignant mesothelioma 43 | 3,232
Astrocytoma, Pilocytic 42 | 3,081
lung carcinoma 42 | 2,843
adult high grade glioma 41 | 3,801
lung adenocarcinoma 41 | 2,716
non-small cell lung cancer 40 | 2,890
ulcerative colitis 40 | 1,819
invasive ductal carcinoma 37 | 2,951
Breast cancer 34 | 3,578
Hypertension 34 | 396
Depressive disorder 33 | 409
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
tuberculosis 33 | 2,010
Schizophrenia 32 | 1,160
oligodendroglioma 32 | 2,850
diabetes mellitus 30 | 1,728
group 3 medulloblastoma 30 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
pancreatic cancer 29 | 2,398
Alcoholic Intoxication, Chronic 28 | 289
Asthma 28 | 385
Mental Depression 27 | 333
Rheumatoid arthritis 26 | 1,191
breast carcinoma 26 | 1,638
cutaneous lupus erythematosus 26 | 1,057
Kidney disease 25 | 430
primitive neuroectodermal tumor 25 | 3,035
Bipolar Disorder 24 | 666
colon cancer 24 | 1,478
ductal carcinoma in situ 24 | 1,745
Multiple Sclerosis 23 | 540
cystic fibrosis 23 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
Atherosclerosis 22 | 291
Pain agnosia 22 | 104
astrocytic glioma 21 | 2,597
Hypertensive disease 20 | 292
Mood Disorders 20 | 184
Pain 20 | 103
adrenocortical carcinoma 19 | 1,428
Arthritis 17 | 290
Cerebrovascular disease 17 | 238
Constipation 17 | 181
Coronary artery disease 17 | 268
Hyperalgesia 17 | 83
Lung disease 17 | 142
Major Depressive Disorder 17 | 301
hepatocellular carcinoma 17 | 547
Alzheimer's disease 16 | 658
Autosomal recessive predisposition 16 | 1,442
Epilepsy 16 | 792
Hypersensitivity 16 | 63
Hypersensitivity reaction type II disease 16 | 253
Liver Cirrhosis, Experimental 16 | 769
Seizures 16 | 596
pituitary cancer 16 | 1,972
subependymal giant cell astrocytoma 16 | 2,287
Kidney cancer 15 | 2,613
Pick disease 15 | 1,894
Pneumonia 15 | 174
mucosa-associated lymphoid tissue lymphoma 15 | 484
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Dermatitis 14 | 157
Heart disease 14 | 306
Inflammatory bowel disease 14 | 151
Unipolar Depression 14 | 250
head and neck cancer 14 | 271
primary Sjogren syndrome 14 | 735
Hypotension 13 | 82
Inflammation 13 | 120
astrocytoma 13 | 1,146
gastric carcinoma 13 | 807
head and neck cancer and chronic obstructive pulmonary disease 13 | 239
Bradycardia 12 | 36
Cocaine-Related Disorders 12 | 92
Diarrhea 12 | 253
Down syndrome 12 | 499
Opiate dependence 12 | 29
Pancreatitis 12 | 123
Substance Withdrawal Syndrome 12 | 55
nasopharyngeal carcinoma 12 | 1,058
Alcohol dependence 11 | 107
Cryptorchidism 11 | 296
Status Epilepticus 11 | 98
active ulcerative colitis 11 | 764
group 4 medulloblastoma 11 | 1,855
juvenile dermatomyositis 11 | 1,187
primary pancreatic ductal adenocarcinoma 11 | 1,109

Tissue

Endocrine System 181 | 18,159
Digestive Tract 169 | 17,369
Female tissues 165 | 17,400
Nervous System 163 | 16,725
Skin and soft tissues 162 | 17,230
Male tissues 161 | 17,142
Blood and immune system 155 | 16,909
Urinary Tract 151 | 16,678
Liver and Pancreas 148 | 16,750
Respiratory system 143 | 16,393
Cardiovascular System 112 | 15,192

Target Family

GPCR 100 | 408
Non-IDG 83 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

Peptide ligand-binding recepto... 188 | 188
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.14265 126.2 303
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.53936 363.5 246
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
C-C motif chemokine 13 CCL13 Tbio Non-IDG -2.02640 99.2 264