Development Level

Tbio 51 | 10,625
Tchem 25 | 1,890
Tclin 6 | 602
Tdark 4 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo turning 1 | 15
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
decreased circulating alkaline... 1 | 41
decreased circulating fructosa... 1 | 31
decreased fasted circulating g... 1 | 49
decreased food intake 1 | 6
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
enlarged heart 1 | 111
enlarged liver 1 | 3
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating aspartat... 1 | 17
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
premature death 1 | 5
small kidney 1 | 10
small superior vagus ganglion 1 | 20
straub tail 1 | 26

Disease

ovarian cancer 40 | 8,484
psoriasis 38 | 6,685
diabetes mellitus 37 | 1,663
medulloblastoma, large-cell 33 | 6,234
osteosarcoma 31 | 7,933
glioblastoma 29 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,988
lung cancer 28 | 4,466
Obesity 27 | 616
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
lung carcinoma 25 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
invasive ductal carcinoma 24 | 2,950
Breast cancer 23 | 3,094
atypical teratoid / rhabdoid tumor 22 | 4,369
interstitial cystitis 20 | 2,299
pituitary cancer 20 | 1,972
Cancer 19 | 2,346
lung adenocarcinoma 18 | 2,713
oligodendroglioma 18 | 2,849
pilocytic astrocytoma 16 | 3,086
ulcerative colitis 16 | 2,087
Hypertension 15 | 287
breast carcinoma 15 | 1,614
malignant mesothelioma 15 | 3,162
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
pediatric high grade glioma 15 | 2,712
Alzheimer's disease 14 | 644
Carcinoma 14 | 2,147
Hypertensive disease 14 | 193
Kidney disease 14 | 396
active Crohn's disease 14 | 918
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,875
pancreatic cancer 14 | 2,300
Atherosclerosis 13 | 275
cystic fibrosis 13 | 1,665
primitive neuroectodermal tumor 13 | 3,031
ependymoma 12 | 2,514
Cerebrovascular disease 11 | 231
Coronary artery disease 11 | 240
Heart disease 11 | 279
Hyperglycemia 11 | 120
Metabolic syndrome X 11 | 155
astrocytic glioma 11 | 2,241
cutaneous lupus erythematosus 11 | 1,056
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 1,557
Adenoma 10 | 165
Atopic dermatitis 10 | 944
Hyperinsulinism 10 | 63
Hypoglycemia 10 | 81
Pick disease 10 | 1,893
gastric carcinoma 10 | 832
non-small cell lung cancer 10 | 2,798
acute quadriplegic myopathy 9 | 1,157
adult high grade glioma 9 | 2,148
primary pancreatic ductal adenocarcinoma 9 | 1,271
sonic hedgehog group medulloblastoma 9 | 1,482
Asthma 8 | 349
Diabetes Mellitus, Non-Insulin-Dependent 8 | 157
Hyperthyroidism 8 | 50
Hypothyroidism 8 | 89
IGA Glomerulonephritis 8 | 454
Lipid metabolism disorder 8 | 102
Liver Cirrhosis, Experimental 8 | 108
Lung disease 8 | 132
Polycystic Ovary Syndrome 8 | 332
Prostatic Neoplasms 8 | 471
Seizures 8 | 95
astrocytoma 8 | 1,493
colon cancer 8 | 1,475
juvenile dermatomyositis 8 | 1,189
posterior fossa group A ependymoma 8 | 1,511
posterior fossa group B ependymoma 8 | 1,530
Amenorrhea 7 | 60
Anemia 7 | 252
Heart failure 7 | 80
Hypotension 7 | 53
Liver disease 7 | 219
Neuropathy 7 | 210
Osteoporosis 7 | 257
Rheumatoid Arthritis 7 | 1,160
atypical teratoid/rhabdoid tumor 7 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
Diabetes Mellitus, Experimental 6 | 106
Down syndrome 6 | 548
Hypogonadism 6 | 70
Infertility 6 | 163
Kidney Diseases 6 | 86
Mammary Neoplasms 6 | 410
Multiple myeloma 6 | 1,327
Weight Gain 6 | 87
dermatomyositis 6 | 933
facioscapulohumeral dystrophy 6 | 286
fibroadenoma 6 | 557
group 3 medulloblastoma 6 | 2,254
medulloblastoma 6 | 1,524
non-small cell lung carcinoma 6 | 413
primary Sjogren syndrome 6 | 789

Tissue

Digestive Tract 86 | 18,473
Endocrine System 86 | 18,512
Female tissues 86 | 18,647
Nervous System 86 | 18,561
Skin and soft tissues 86 | 18,115
Blood and immune system 85 | 17,995
Liver and Pancreas 85 | 18,136
Urinary Tract 85 | 18,444
Cardiovascular System 84 | 17,958
Male tissues 83 | 17,969
Respiratory system 80 | 17,484

Target Family

Non-IDG 43 | 11,971
Enzyme 29 | 4,146
Transcription Factor 6 | 1,400
GPCR 4 | 406
Transporter 4 | 473

Reactome Pathway

Peptide hormone metabolism 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.22946 184.9 247
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81004 644.6 267
Exocyst complex component 8 EXOC8 Tbio Non-IDG -1.17455 14.6 65
Rab effector MyRIP MYRIP Tbio Non-IDG -1.02418 12.6 110
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.59694 391.4 341
Zinc transporter 8 SLC30A8 Tbio Transporter -2.13184 153.6 103
ERO1-like protein beta ERO1B Tbio Non-IDG -0.94346 9.49 83
Carboxypeptidase E CPE Tbio Enzyme -2.97987 983.1 216