Development Level

Tbio 53 | 11,651
Tchem 21 | 1,388
Tclin 5 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
abnormal embryo size 4 | 220
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
hypoactivity 3 | 132
increased total body fat amoun... 3 | 134
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased startle reflex 2 | 112
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
abnormal skin appearance 1 | 3
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
aorta stenosis 1 | 2
cyanosis 1 | 7
decreased caudal vertebrae num... 1 | 53
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged liver 1 | 2
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
mammalian phenotype 1 | 17
pallor 1 | 34
premature death 1 | 5
scaly skin 1 | 4
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thick skin 1 | 4

Disease

Carcinoma 46 | 11,493
ovarian cancer 40 | 8,520
diabetes mellitus 37 | 1,728
psoriasis 37 | 6,694
medulloblastoma, large-cell 32 | 6,241
glioblastoma 31 | 5,792
osteosarcoma 31 | 7,950
lung cancer 29 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
Obesity 26 | 678
ependymoma 26 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
atypical teratoid / rhabdoid tumor 25 | 5,112
lung carcinoma 25 | 2,843
invasive ductal carcinoma 24 | 2,951
Breast cancer 23 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
Cancer 20 | 2,499
pituitary cancer 20 | 1,972
interstitial cystitis 19 | 2,312
Hypertension 18 | 396
oligodendroglioma 18 | 2,850
Astrocytoma, Pilocytic 16 | 3,081
adult high grade glioma 16 | 3,801
breast carcinoma 16 | 1,638
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
astrocytic glioma 15 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
ulcerative colitis 15 | 1,819
Autosomal recessive predisposition 14 | 1,442
Kidney cancer 14 | 2,613
Kidney disease 14 | 430
active Crohn's disease 14 | 922
ductal carcinoma in situ 14 | 1,745
group 3 medulloblastoma 14 | 4,104
pancreatic cancer 14 | 2,398
Alzheimer's disease 13 | 658
Hypertensive disease 13 | 292
Liver Cirrhosis, Experimental 13 | 769
Schizophrenia 13 | 1,160
Bipolar Disorder 12 | 666
Hyperglycemia 12 | 137
Seizures 12 | 596
cystic fibrosis 12 | 1,696
group 4 medulloblastoma 12 | 1,855
primitive neuroectodermal tumor 12 | 3,035
Atherosclerosis 11 | 291
Coronary artery disease 11 | 268
Depressive disorder 11 | 409
Hypoglycemia 11 | 152
cutaneous lupus erythematosus 11 | 1,057
non-small cell lung cancer 11 | 2,890
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 2,010
Adenoma 10 | 167
Atopic dermatitis 10 | 952
Cerebrovascular disease 10 | 238
Heart disease 10 | 306
Mental Depression 10 | 333
Pick disease 10 | 1,894
gastric carcinoma 10 | 807
Polycystic ovary syndrome 9 | 360
acute quadriplegic myopathy 9 | 1,158
Alcoholic Intoxication, Chronic 8 | 289
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Diabetes Mellitus, Type 2 8 | 142
Epilepsy 8 | 792
Hyperinsulinism 8 | 133
Hyperthyroidism 8 | 53
Hypothyroidism 8 | 122
Lung disease 8 | 142
Small head 8 | 374
colon cancer 8 | 1,478
juvenile dermatomyositis 8 | 1,187
Abnormality of metabolism/homeostasis 7 | 134
Anemia 7 | 365
Asthma 7 | 385
Lipid metabolism disorder 7 | 114
Liver disease 7 | 237
Osteoporosis 7 | 363
Prostatic Neoplasms 7 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
pediatric high grade glioma 7 | 1,064
primary pancreatic ductal adenocarcinoma 7 | 1,109
Cognitive delay 6 | 608
Diarrhea 6 | 253
Down syndrome 6 | 499
Global developmental delay 6 | 608
Infertility 6 | 188
Liver Cirrhosis 6 | 181
Major Depressive Disorder 6 | 301
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332
Neuropathy 6 | 261
Rheumatoid arthritis 6 | 1,191
Unipolar Depression 6 | 250
dermatomyositis 6 | 966
fibroadenoma 6 | 559
medulloblastoma 6 | 720

Tissue

Digestive Tract 80 | 17,369
Endocrine System 80 | 18,159
Female tissues 77 | 17,400
Liver and Pancreas 77 | 16,750
Blood and immune system 75 | 16,909
Nervous System 75 | 16,725
Respiratory system 75 | 16,393
Skin and soft tissues 73 | 17,230
Male tissues 72 | 17,142
Urinary Tract 72 | 16,678
Cardiovascular System 66 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 27 | 4,145
Transcription Factor 6 | 1,400
GPCR 4 | 408
Transporter 4 | 473

Reactome Pathway

Peptide hormone metabolism 83 | 83
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Exocyst complex component 1 EXOC1 Tbio Non-IDG -1.85438 74.2 51
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.77097 54.9 83
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.30319 204.9 308
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81719 655.7 311
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
ERO1-like protein beta ERO1B Tbio Non-IDG -0.92111 8.62 114
Pro-opiomelanocortin POMC Tbio Non-IDG -4.56004 36591.2 1334
Angiotensinogen AGT Tbio Non-IDG -3.24591 1711.3 695