Development Level

Tbio 12 | 11,445

IMPC Phenotype

abnormal kidney morphology 1 | 65
decreased leukocyte cell numbe... 1 | 73
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased total retina thickne... 1 | 4

Disease

Carcinoma 6 | 11,493
psoriasis 6 | 6,694
Nephrogenic Diabetes Insipidus 5 | 16
Brain Edema 4 | 50
Meniere's disease 4 | 24
Oligohydramnios 3 | 52
Polyhydramnios 3 | 108
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
Cancer 2 | 2,499
Constipation 2 | 181
Diabetes insipidus 2 | 18
Diarrhea 2 | 253
Epilepsy 2 | 792
Inappropriate ADH syndrome 2 | 5
Kidney disease 2 | 430
Multiple Sclerosis 2 | 540
Ureteral disease 2 | 3
Urinary tract obstruction 2 | 11
aldosterone-producing adenoma 2 | 665
chronic rhinosinusitis 2 | 512
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
ulcerative colitis 2 | 1,819
Abnormal blistering of the skin 1 | 54
Acute Promyelocytic Leukemia 1 | 40
Acute disseminated encephalomyelitis 1 | 7
Adenocarcinoma of lung 1 | 142
Anhidrosis 1 | 23
Anorexia 1 | 43
Arsenic Poisoning 1 | 62
Autistic Disorder 1 | 364
Autosomal dominant polycystic kidney disease 1 | 31
Autosomal recessive polycystic kidney disease 1 | 41
Bladder Neoplasm 1 | 112
Blister of skin 1 | 54
CATARACT 16, MULTIPLE TYPES 1 | 15
Carcinoma, Squamous Cell 1 | 110
Cardiomyopathies 1 | 110
Congestive heart failure 1 | 113
Dacryoadenitis 1 | 10
Diaphragmatic Hernia 1 | 40
Disease Models, Animal 1 | 155
Dry eye syndrome 1 | 18
Dyschezia 1 | 135
Encephalitis 1 | 64
Erythema 1 | 58
Esophageal Neoplasms 1 | 69
Fever 1 | 138
Flushing 1 | 60
Hernia, Diaphragmatic 1 | 40
Hydrarthrosis 1 | 4
Hypokalemia 1 | 52
Impairment of urinary concentration 1 | 5
Intestinal tuberculosis 1 | 5
Irritable bowel syndrome 1 | 60
Irritation - emotion 1 | 68
Keratosis 1 | 37
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Leukemia, Promyelocytic, Acute 1 | 36
Liver Cirrhosis 1 | 181
Liver Cirrhosis, Experimental 1 | 769
Lymphatic Metastasis 1 | 15
Metabolic acidosis 1 | 90
Nausea and vomiting 1 | 97
Neonatal onset 1 | 21
Nonepidermolytic palmoplantar keratoderma 1 | 12
Nuclear cataract 1 | 19
Nuclear non-senile cataract 1 | 18
Ovarian Neoplasms 1 | 102
Palmoplantar keratosis 1 | 74
Papule 1 | 43
Polydipsia 1 | 15
Polyuria 1 | 23
Pompholyx 1 | 4
Presbyopia 1 | 20
Pruritus 1 | 58
Respiratory Failure 1 | 104
Sjogren's syndrome 1 | 26
Skin Neoplasms 1 | 69
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Spinal Cord Injuries 1 | 8
Spinal cord disease 1 | 25
Squamous cell carcinoma 1 | 129
Urinary Bladder Neoplasms 1 | 114
Vomiting 1 | 116
ovarian neoplasm 1 | 99
permanent atrial fibrillation 1 | 45

Tissue

Digestive Tract 12 | 17,369
Liver and Pancreas 12 | 16,750
Endocrine System 11 | 18,159
Male tissues 11 | 17,142
Nervous System 10 | 16,725
Blood and immune system 9 | 16,909
Female tissues 9 | 17,400
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Cardiovascular System 8 | 15,192
Respiratory system 8 | 16,393

Target Family

Non-IDG 12 | 12,091

Reactome Pathway

Passive transport by Aquaporin... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aquaporin-6 AQP6 Tbio Non-IDG -1.52088 32.7 57
Aquaporin-9 AQP9 Tbio Non-IDG -2.13315 155.0 84
Aquaporin-8 AQP8 Tbio Non-IDG -2.06724 116.3 124
Aquaporin-10 AQP10 Tbio Non-IDG -1.23305 16.1 85
Aquaporin-11 AQP11 Tbio Non-IDG -1.49454 36.5 82
Aquaporin-7 AQP7 Tbio Non-IDG -2.03961 165.7 101
Aquaporin-4 AQP4 Tbio Non-IDG -3.33435 2159.1 358
Aquaporin-12A AQP12A Tbio Non-IDG -0.93600 10.8 63
Aquaporin-3 AQP3 Tbio Non-IDG -2.61717 403.0 260
Aquaporin-2 AQP2 Tbio Non-IDG -2.95328 957.7 394