Development Level

Tbio 9 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal urinary bladder morph... 1 | 11
decreased fasted circulating g... 1 | 65
embryonic lethality prior to o... 1 | 239
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 10 | 11,493
ovarian cancer 10 | 8,520
Cancer 9 | 2,499
osteosarcoma 9 | 7,950
Breast cancer 6 | 3,578
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
Basal cell carcinoma 4 | 54
Basal cell nevi 4 | 23
Cell Transformation, Neoplastic 4 | 97
Kidney cancer 4 | 2,613
Melanoma 4 | 711
Noonan syndrome 4 | 34
Pick disease 4 | 1,894
Stomach Neoplasms 4 | 300
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
Abnormal dermatoglyphic pattern 3 | 24
Abnormality of vision 3 | 40
Adenocarcinoma of lung 3 | 142
Adenocarcinoma of lung (disorder) 3 | 60
Alopecia 3 | 115
Asymmetric growth 3 | 5
Asymmetry of the posterior cranium 3 | 20
Bladder Neoplasm 3 | 112
Bleeding tendency 3 | 37
Blepharoptosis 3 | 231
Carcinoma, Squamous Cell 3 | 110
Cardiac Arrhythmia 3 | 103
Cardiac conduction abnormalities 3 | 78
Cardiofaciocutaneous syndrome 3 | 15
Cerebellar hypoplasia and atrophy 3 | 41
Conduction disorder of the heart 3 | 79
Congenital ocular coloboma (disorder) 3 | 40
Congenital pectus carinatum 3 | 52
Connective tissue cancer 3 | 10
Costello Syndrome 3 | 17
Cranial asymmetry 3 | 5
Curly hair (finding) 3 | 14
Decreased to absent deep tendon reflexes 3 | 42
Defect of vertebral segmentation 3 | 17
Dental abnormalities 3 | 60
Downward slant of palpebral fissure 3 | 158
EKG abnormalities 3 | 78
Electrocardiogram abnormal 3 | 81
Electrocardiogram change 3 | 78
Electroencephalogram abnormal 3 | 101
Excess nuchal skin 3 | 30
Facial asymmetry 3 | 32
Fetal overgrowth 3 | 16
Fibrous skin tumor of tuberous sclerosis 3 | 18
Flattening of cranial vault 3 | 20
Flattening of head 3 | 20
Frequent fractures 3 | 53
Frontal bossing 3 | 157
Full lower lip 3 | 64
Generalized osteopenia 3 | 99
Generalized overgrowth 3 | 16
Genu recurvatum 3 | 12
Hemangioma 3 | 69
Hemangioma, Cavernous 3 | 20
Hemimegalencephaly 3 | 5
Horseshoe Kidney 3 | 16
Hyperreflexia 3 | 209
Hypophosphatemic Rickets 3 | 11
Hypopigmentation disorder 3 | 25
Ichthyoses 3 | 41
Increased fracture rate 3 | 53
Irregular hyperpigmentation 3 | 33
Isolated cases 3 | 72
Joint hyperflexibility 3 | 78
Kyphoscoliosis deformity of spine 3 | 60
Melanocytic nevus 3 | 43
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Neoplasms, Experimental 3 | 40
Neoplastic Cell Transformation 3 | 89
Noncancerous mole 3 | 28
Osteopenia 3 | 99
Overgrowth 3 | 16
Papillary thyroid carcinoma 3 | 43
Plagiocephaly 3 | 20
Plagiocephaly, Nonsynostotic 3 | 20
Porencephaly 3 | 20
Prominent back of the head 3 | 21
Prominent lower lip 3 | 64
Prominent occiput 3 | 21
Rhabdomyosarcoma 3 | 39
Rhomboid shaped head 3 | 20
Sebaceous adenoma 3 | 26
Squamous cell carcinoma 3 | 129
Telecanthus 3 | 62
Thyroid cancer 3 | 36
Tooth Abnormalities 3 | 69
Upper respiratory tract disease 3 | 15
Urinary Bladder Neoplasms 3 | 114
Varying degree of multiple fractures 3 | 53

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 6 | 4,145
Non-IDG 6 | 12,091
Kinase 1 | 634

Reactome Pathway

PTK6 Regulates RHO GTPases, RA... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Paxillin PXN Tbio Non-IDG -2.99437 902.9 1251
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.20657 183.7 368
Engulfment and cell motility protein 1 ELMO1 Tbio Non-IDG -1.62242 45.4 178
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Adapter molecule crk CRK Tbio Non-IDG -2.55195 357.0 432