Development Level

Tchem 3 | 1,598
Tbio 1 | 11,445
Tclin 1 | 613

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal urinary bladder morph... 1 | 11
edema 1 | 59
female infertility 1 | 60
hyperactivity 1 | 148
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499

Disease

Cancer 5 | 2,499
ovarian cancer 4 | 8,520
Carcinoma, Hepatocellular 3 | 228
Liver carcinoma 3 | 240
lung adenocarcinoma 3 | 2,716
osteosarcoma 3 | 7,950
psoriasis 3 | 6,694
Astrocytoma, Pilocytic 2 | 3,081
Breast Neoplasms 2 | 445
Carcinoma 2 | 11,493
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Ovarian Neoplasms 2 | 102
Stomach Neoplasms 2 | 300
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
ovarian neoplasm 2 | 99
primitive neuroectodermal tumor 2 | 3,035
Abdominal pain, episodic 1 | 9
Abnormality of the lymphatic system 1 | 14
Adenoma, Liver Cell 1 | 8
Adrenal cortical adenoma 1 | 19
Alopecia areata 1 | 41
Angiofibroma 1 | 7
Animal Mammary Neoplasms 1 | 136
Bladder Neoplasm 1 | 112
Blastic phase chronic myeloid leukemia 1 | 58
Brain Neoplasms 1 | 33
Carney complex 1 | 25
Chloracne 1 | 32
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Chronic phase chronic myeloid leukemia 1 | 45
Diarrhea 1 | 253
Disease Progression 1 | 136
Dry skin 1 | 75
Dysgraphia 1 | 20
Esophagitis 1 | 35
Freckles 1 | 33
Growth hormone excess 1 | 14
Hair shaft abnormalities 1 | 30
Helicobacter Infections 1 | 5
Hepatocellular Adenoma 1 | 10
Hereditary Melanoma 1 | 12
Hormone receptor positive malignant neoplasm of breast 1 | 10
Hypercalcemia 1 | 59
Hyperinsulinaemic hypoglycaemia 1 | 16
Hyperparathyroidism 1 | 48
Increased serum parathyroid hormone 1 | 14
Insulinoma 1 | 24
Intestinal Neoplasms 1 | 12
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Lipoma 1 | 32
Liposarcoma 1 | 20
Liver neoplasms 1 | 130
Lung Neoplasms 1 | 232
Lymphatic Diseases 1 | 14
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Melanocytic nevus 1 | 43
Mesothelioma 1 | 38
Multiple Endocrine Neoplasia Type 1 1 | 29
Multiple endocrine neoplasia type 2A 1 | 20
Neoplasms, Experimental 1 | 40
Nevus 1 | 19
Parathyroid Adenoma 1 | 19
Parathyroid hyperplasia 1 | 6
Peptic Ulcer 1 | 27
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 1 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 1 | 47
Primary hyperparathyroidism 1 | 5
Prolactinoma 1 | 11
Prostatic Intraepithelial Neoplasia 1 | 11
Prostatic Intraepithelial Neoplasias 1 | 11
Rectal Neoplasms 1 | 18
Recurrence 1 | 33
Rosacea 1 | 25
Sezary Syndrome 1 | 27
Stomach cancer 1 | 30
Systemic lupus erythematosus 1 | 194
Thyroid Gland Follicular Adenoma 1 | 9
Urinary Bladder Neoplasms 1 | 114
Urinary bladder cancer 1 | 36
Xerosis 1 | 75
Zollinger-Ellison syndrome 1 | 18
familial melanoma 1 | 10
hair abnormalities (non-specific) 1 | 30
intermittent abdominal pain 1 | 9

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Kinase 3 | 634
Enzyme 1 | 4,145
Non-IDG 1 | 12,091

Reactome Pathway

PTK6 Regulates Cell Cycle 5 | 5
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.20657 183.7 368
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.44266 2522.8 1114
Cyclin-dependent kinase 4 CDK4 Tclin Kinase -3.24878 1546.3 803
G1/S-specific cyclin-E1 CCNE1 Tchem Non-IDG -2.47823 262.4 894
Cyclin-dependent kinase inhibitor 1B CDKN1B Tbio Enzyme -3.11753 1246.6 1886