Development Level

Tbio 99 | 11,445
Tchem 26 | 1,598
Tclin 12 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to t... 5 | 278
increased lean body mass 5 | 172
decreased body weight 4 | 161
embryonic lethality prior to o... 4 | 239
increased total body fat amoun... 4 | 134
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased caudal vertebrae num... 3 | 53
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased hemoglobin content 3 | 68
increased startle reflex 3 | 112
limb grasping 3 | 41
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal locomotor activation 2 | 16
abnormal startle reflex 2 | 15
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
edema 2 | 59
enlarged heart 2 | 210
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
small spleen 2 | 19
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
female infertility 1 | 60
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

ovarian cancer 94 | 8,520
Carcinoma 89 | 11,493
osteosarcoma 64 | 7,950
glioblastoma 53 | 5,792
lung cancer 51 | 4,740
psoriasis 51 | 6,694
medulloblastoma, large-cell 50 | 6,241
Cancer 49 | 2,499
Multiple myeloma 37 | 1,332
Breast cancer 36 | 3,578
atypical teratoid / rhabdoid tumor 36 | 5,112
ependymoma 30 | 4,679
group 3 medulloblastoma 27 | 4,104
adult high grade glioma 24 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
oligodendroglioma 22 | 2,850
Kidney cancer 20 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
subependymal giant cell astrocytoma 20 | 2,287
malignant mesothelioma 19 | 3,232
non-small cell lung cancer 19 | 2,890
primitive neuroectodermal tumor 19 | 3,035
group 4 medulloblastoma 18 | 1,855
invasive ductal carcinoma 18 | 2,951
dermatomyositis 17 | 966
diabetes mellitus 17 | 1,728
astrocytic glioma 16 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
HIV Infections 15 | 102
Pick disease 15 | 1,894
Schizophrenia 15 | 1,160
lung adenocarcinoma 15 | 2,716
pancreatic cancer 15 | 2,398
Waldenstrons macroglobulinemia 14 | 765
Astrocytoma, Pilocytic 13 | 3,081
astrocytoma 13 | 1,146
breast carcinoma 13 | 1,638
juvenile dermatomyositis 12 | 1,187
tuberculosis 12 | 2,010
Intellectual disability 11 | 1,016
Rheumatoid arthritis 11 | 1,191
lung carcinoma 11 | 2,843
ulcerative colitis 11 | 1,819
Breast Neoplasms 10 | 445
Carcinoma, Squamous Cell 10 | 110
Epilepsy 10 | 792
Mammary Neoplasms 10 | 425
Squamous cell carcinoma 10 | 129
acute myeloid leukemia 10 | 783
non primary Sjogren syndrome sicca 10 | 891
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Osteoporosis 9 | 363
Vascular disease 9 | 319
acute quadriplegic myopathy 9 | 1,158
ductal carcinoma in situ 9 | 1,745
interstitial cystitis 9 | 2,312
Melanoma 8 | 711
Obesity 8 | 678
Seizures 8 | 596
adrenocortical carcinoma 8 | 1,428
pediatric high grade glioma 8 | 1,064
Anemia 7 | 365
Endometrial cancer 7 | 311
Kidney disease 7 | 430
Lung Neoplasms 7 | 232
Neoplasm Metastasis 7 | 168
Ovarian Neoplasms 7 | 102
Parkinson's disease 7 | 392
Prostatic Neoplasms 7 | 495
Stomach Neoplasms 7 | 300
ovarian neoplasm 7 | 99
pituitary cancer 7 | 1,972
progressive supranuclear palsy 7 | 676
Amyotrophic lateral sclerosis 6 | 451
Asthma 6 | 385
Bipolar Disorder 6 | 666
Colonic Neoplasms 6 | 142
Dull intelligence 6 | 645
Endometriosis 6 | 540
Hypertension 6 | 396
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Neoplasm Invasiveness 6 | 161
Poor school performance 6 | 645
Skin cancer 6 | 469
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
esophageal adenocarcinoma 6 | 737
medulloblastoma 6 | 720
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
Arthritis 5 | 290
Heart disease 5 | 306
Lung disease 5 | 142
Polycystic ovary syndrome 5 | 360
nasopharyngeal carcinoma 5 | 1,058

Tissue

Endocrine System 140 | 18,159
Nervous System 139 | 16,725
Urinary Tract 139 | 16,678
Blood and immune system 138 | 16,909
Digestive Tract 138 | 17,369
Female tissues 138 | 17,400
Male tissues 138 | 17,142
Respiratory system 138 | 16,393
Skin and soft tissues 138 | 17,230
Liver and Pancreas 137 | 16,750
Cardiovascular System 136 | 15,192

Target Family

Enzyme 55 | 4,145
Non-IDG 45 | 12,091
Epigenetic 14 | 242
Transcription Factor 14 | 1,400
Kinase 10 | 634
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

Reactome Pathway

PTEN Regulation 142 | 142
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195