Development Level

Tbio 80 | 11,445
Tchem 24 | 1,598
Tclin 8 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 7 | 499
abnormal embryo size 5 | 220
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
increased startle reflex 5 | 112
abnormal behavior 4 | 298
increased or absent threshold ... 4 | 101
abnormal retina morphology 3 | 71
decreased circulating serum al... 3 | 82
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
pale yolk sac 2 | 25
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal motor capabilities-co... 1 | 5
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cataract 1 | 92
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased startle reflex 1 | 75
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Carcinoma 84 | 11,493
ovarian cancer 73 | 8,520
osteosarcoma 68 | 7,950
psoriasis 66 | 6,694
medulloblastoma, large-cell 47 | 6,241
malignant mesothelioma 41 | 3,232
glioblastoma 34 | 5,792
atypical teratoid / rhabdoid tumor 33 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
lung cancer 33 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Cancer 31 | 2,499
Obesity 29 | 678
diabetes mellitus 29 | 1,728
group 3 medulloblastoma 29 | 4,104
Breast cancer 27 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Kidney cancer 26 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
ependymoma 22 | 4,679
primitive neuroectodermal tumor 21 | 3,035
tuberculosis 20 | 2,010
Pick disease 19 | 1,894
astrocytic glioma 19 | 2,597
oligodendroglioma 19 | 2,850
adult high grade glioma 18 | 3,801
pituitary cancer 18 | 1,972
subependymal giant cell astrocytoma 18 | 2,287
Rheumatoid arthritis 17 | 1,191
interstitial cystitis 17 | 2,312
invasive ductal carcinoma 17 | 2,951
Schizophrenia 16 | 1,160
adrenocortical carcinoma 16 | 1,428
Atherosclerosis 15 | 291
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
cystic fibrosis 15 | 1,696
ductal carcinoma in situ 15 | 1,745
pancreatic cancer 15 | 2,398
ulcerative colitis 15 | 1,819
astrocytoma 14 | 1,146
non-small cell lung cancer 14 | 2,890
Astrocytoma, Pilocytic 13 | 3,081
Carcinoma, Hepatocellular 13 | 228
Fatty liver disease 13 | 103
Lipid metabolism disorder 13 | 114
Liver Cirrhosis, Experimental 13 | 769
Liver carcinoma 13 | 240
active ulcerative colitis 13 | 764
acute quadriplegic myopathy 13 | 1,158
breast carcinoma 13 | 1,638
lung carcinoma 13 | 2,843
colon cancer 12 | 1,478
lung adenocarcinoma 12 | 2,716
Autosomal recessive predisposition 11 | 1,442
Bipolar Disorder 11 | 666
Endometriosis 11 | 540
Epilepsy 11 | 792
Hepatomegaly 11 | 285
Prostatic Neoplasms 11 | 495
Seizures 11 | 596
aldosterone-producing adenoma 11 | 665
spina bifida 11 | 1,074
Chemical and Drug Induced Liver Injury 10 | 195
Diabetes Mellitus, Experimental 10 | 108
active Crohn's disease 10 | 922
Coronary artery disease 9 | 268
Mental Depression 9 | 333
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
group 4 medulloblastoma 9 | 1,855
juvenile dermatomyositis 9 | 1,187
Cholestasis 8 | 155
Depressive disorder 8 | 409
Hypertension 8 | 396
Intellectual disability 8 | 1,016
Liver disease 8 | 237
acute myeloid leukemia 8 | 783
cutaneous lupus erythematosus 8 | 1,057
dermatomyositis 8 | 966
fibroadenoma 8 | 559
mucosa-associated lymphoid tissue lymphoma 8 | 484
pediatric high grade glioma 8 | 1,064
Atopic dermatitis 7 | 952
Autistic Disorder 7 | 364
Cardiomegaly 7 | 116
Heart disease 7 | 306
Hypertensive disease 7 | 292
Insulin Resistance 7 | 72
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
gastric carcinoma 7 | 807
non primary Sjogren syndrome sicca 7 | 891
pancreatic carcinoma 7 | 562
primary pancreatic ductal adenocarcinoma 7 | 1,109
Amyotrophic lateral sclerosis 6 | 451
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
posterior fossa group B ependymoma 6 | 416

Tissue

Digestive Tract 116 | 17,369
Liver and Pancreas 116 | 16,750
Skin and soft tissues 116 | 17,230
Endocrine System 115 | 18,159
Female tissues 115 | 17,400
Male tissues 115 | 17,142
Respiratory system 114 | 16,393
Urinary Tract 114 | 16,678
Blood and immune system 113 | 16,909
Nervous System 113 | 16,725
Cardiovascular System 108 | 15,192

Target Family

Enzyme 46 | 4,145
Non-IDG 30 | 12,091
Transcription Factor 17 | 1,400
Nuclear Receptor 10 | 48
Epigenetic 7 | 242
Kinase 3 | 634
Transporter 2 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

PPARA activates gene expressio... 116 | 116
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Mediator of RNA polymerase II transcription subunit 29 MED29 Tbio Enzyme -1.76053 56.0 45
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.68768 52.8 77
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137