Development Level

Tbio 80 | 11,445
Tchem 24 | 1,598
Tclin 8 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 7 | 499
abnormal embryo size 5 | 220
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
increased startle reflex 5 | 112
abnormal behavior 4 | 298
increased or absent threshold ... 4 | 101
abnormal retina morphology 3 | 71
decreased circulating serum al... 3 | 82
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
pale yolk sac 2 | 25
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal motor capabilities-co... 1 | 5
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cataract 1 | 92
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased startle reflex 1 | 75
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Carcinoma 84 | 11,493
ovarian cancer 73 | 8,520
osteosarcoma 68 | 7,950
psoriasis 66 | 6,694
medulloblastoma, large-cell 47 | 6,241
malignant mesothelioma 41 | 3,232
glioblastoma 34 | 5,792
atypical teratoid / rhabdoid tumor 33 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
lung cancer 33 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Cancer 31 | 2,499
Obesity 29 | 678
diabetes mellitus 29 | 1,728
group 3 medulloblastoma 29 | 4,104
Breast cancer 27 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Kidney cancer 26 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
ependymoma 22 | 4,679
primitive neuroectodermal tumor 21 | 3,035
tuberculosis 20 | 2,010
Pick disease 19 | 1,894
astrocytic glioma 19 | 2,597
oligodendroglioma 19 | 2,850
adult high grade glioma 18 | 3,801
pituitary cancer 18 | 1,972
subependymal giant cell astrocytoma 18 | 2,287
Rheumatoid arthritis 17 | 1,191
interstitial cystitis 17 | 2,312
invasive ductal carcinoma 17 | 2,951
Schizophrenia 16 | 1,160
adrenocortical carcinoma 16 | 1,428
Atherosclerosis 15 | 291
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
cystic fibrosis 15 | 1,696
ductal carcinoma in situ 15 | 1,745
pancreatic cancer 15 | 2,398
ulcerative colitis 15 | 1,819
astrocytoma 14 | 1,146
non-small cell lung cancer 14 | 2,890
Astrocytoma, Pilocytic 13 | 3,081
Carcinoma, Hepatocellular 13 | 228
Fatty liver disease 13 | 103
Lipid metabolism disorder 13 | 114
Liver Cirrhosis, Experimental 13 | 769
Liver carcinoma 13 | 240
active ulcerative colitis 13 | 764
acute quadriplegic myopathy 13 | 1,158
breast carcinoma 13 | 1,638
lung carcinoma 13 | 2,843
colon cancer 12 | 1,478
lung adenocarcinoma 12 | 2,716
Autosomal recessive predisposition 11 | 1,442
Bipolar Disorder 11 | 666
Endometriosis 11 | 540
Epilepsy 11 | 792
Hepatomegaly 11 | 285
Prostatic Neoplasms 11 | 495
Seizures 11 | 596
aldosterone-producing adenoma 11 | 665
spina bifida 11 | 1,074
Chemical and Drug Induced Liver Injury 10 | 195
Diabetes Mellitus, Experimental 10 | 108
active Crohn's disease 10 | 922
Coronary artery disease 9 | 268
Mental Depression 9 | 333
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
group 4 medulloblastoma 9 | 1,855
juvenile dermatomyositis 9 | 1,187
Cholestasis 8 | 155
Depressive disorder 8 | 409
Hypertension 8 | 396
Intellectual disability 8 | 1,016
Liver disease 8 | 237
acute myeloid leukemia 8 | 783
cutaneous lupus erythematosus 8 | 1,057
dermatomyositis 8 | 966
fibroadenoma 8 | 559
mucosa-associated lymphoid tissue lymphoma 8 | 484
pediatric high grade glioma 8 | 1,064
Atopic dermatitis 7 | 952
Autistic Disorder 7 | 364
Cardiomegaly 7 | 116
Heart disease 7 | 306
Hypertensive disease 7 | 292
Insulin Resistance 7 | 72
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
gastric carcinoma 7 | 807
non primary Sjogren syndrome sicca 7 | 891
pancreatic carcinoma 7 | 562
primary pancreatic ductal adenocarcinoma 7 | 1,109
Amyotrophic lateral sclerosis 6 | 451
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
posterior fossa group B ependymoma 6 | 416

Tissue

Digestive Tract 116 | 17,369
Liver and Pancreas 116 | 16,750
Skin and soft tissues 116 | 17,230
Endocrine System 115 | 18,159
Female tissues 115 | 17,400
Male tissues 115 | 17,142
Respiratory system 114 | 16,393
Urinary Tract 114 | 16,678
Blood and immune system 113 | 16,909
Nervous System 113 | 16,725
Cardiovascular System 108 | 15,192

Target Family

Enzyme 46 | 4,145
Non-IDG 30 | 12,091
Transcription Factor 17 | 1,400
Nuclear Receptor 10 | 48
Epigenetic 7 | 242
Kinase 3 | 634
Transporter 2 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

PPARA activates gene expressio... 116 | 116
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 29 MED29 Tbio Enzyme -1.76053 56.0 45
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.68768 52.8 77
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Mediator of RNA polymerase II transcription subunit 31 MED31 Tbio Enzyme -1.19048 15.1 61
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135