Development Level

Tbio 27 | 11,651
Tchem 15 | 1,388
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased prepulse inhibition 4 | 82
increased lean body mass 4 | 172
increased startle reflex 4 | 112
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
increased blood urea nitrogen ... 3 | 48
abnormal locomotor activation 2 | 16
abnormal startle reflex 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
impaired pupillary reflex 2 | 26
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased thermal nociceptive ... 2 | 9
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal iris morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased CD4-positive, alpha ... 1 | 4
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
irregularly shaped pupil 1 | 7
persistence of hyaloid vascula... 1 | 33
prolonged QRS complex duration 1 | 8
sclerocornea 1 | 2
small spleen 1 | 19
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 38 | 11,493
osteosarcoma 25 | 7,950
ovarian cancer 25 | 8,520
Cancer 23 | 2,499
Kidney cancer 20 | 2,613
Breast cancer 15 | 3,578
atypical teratoid / rhabdoid tumor 15 | 5,112
group 3 medulloblastoma 15 | 4,104
lung cancer 15 | 4,740
medulloblastoma, large-cell 14 | 6,241
glioblastoma 13 | 5,792
malignant mesothelioma 12 | 3,232
primitive neuroectodermal tumor 12 | 3,035
psoriasis 11 | 6,694
Pick disease 10 | 1,894
ependymoma 9 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
oligodendroglioma 8 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Intellectual disability 7 | 1,016
Leukemia 7 | 104
Liver cancer 7 | 604
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Breast Neoplasms 6 | 445
Kabuki syndrome 6 | 27
Mammary Neoplasms 6 | 425
Melanoma 6 | 711
Neurodevelopmental Disorders 6 | 70
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
spina bifida 6 | 1,074
Endometrial cancer 5 | 311
Leukemia, Myelocytic, Acute 5 | 120
Lymphoid leukemia 5 | 160
Multiple myeloma 5 | 1,332
Muscle hypotonia 5 | 571
Schizophrenia 5 | 1,160
adult high grade glioma 5 | 3,801
Astrocytoma, Pilocytic 4 | 3,081
Cognitive delay 4 | 608
Downward slant of palpebral fissure 4 | 158
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Immune system cancer 4 | 140
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Skin cancer 4 | 469
Sotos syndrome 4 | 13
Strabismus 4 | 270
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
Acquired scoliosis 3 | 281
Adenoid Cystic Carcinoma 3 | 99
Autoimmune thrombocytopenia 3 | 22
Bladder Neoplasm 3 | 112
Byzanthine arch palate 3 | 194
Carcinoma, Adenoid Cystic 3 | 99
Carcinoma, Hepatocellular 3 | 228
Colonic Neoplasms 3 | 142
Congenital Epicanthus 3 | 177
Curvature of spine 3 | 282
DOID:2627 3 | 94
Dilated ventricles (finding) 3 | 121
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Feeding difficulties in infancy 3 | 175
Immune thrombocytopenic purpura 3 | 24
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large intestine cancer 3 | 126
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Leukemia, Myeloid 3 | 18
Liver carcinoma 3 | 240
MYELODYSPLASTIC SYNDROME 3 | 53
Macrotia 3 | 87
Myeloid Leukemia 3 | 19
Pediatric failure to thrive 3 | 365
Radioulnar synostosis 3 | 35
Seizures 3 | 596
Urinary Bladder Neoplasms 3 | 114
acute myeloid leukemia 3 | 783
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010

Tissue

Blood and immune system 43 | 16,909
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 42 | 15,192
Digestive Tract 42 | 17,369
Respiratory system 42 | 16,393

Target Family

Epigenetic 25 | 242
Non-IDG 9 | 12,091
TF/Epigenetic 6 | 38
Transcription Factor 3 | 1,400
Enzyme 1 | 4,145

Reactome Pathway

PKMTs methylate histone lysine... 44 | 44
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -1.05387 12.8 177
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.27556 174.3 306
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.53887 4.67 95
Polycomb protein EED EED Tbio Non-IDG -2.23450 157.4 278
WD repeat-containing protein 5 WDR5 Tchem Non-IDG -2.10077 115.4 299
Activating transcription factor 7-interacting protein 1 ATF7IP Tbio Non-IDG -1.14728 13.6 55
MDS1 and EVI1 complex locus protein EVI1 MECOM Tbio TF/Epigenetic -1.84060 124.5 317