Development Level

Tbio 23 | 10,625
Tchem 18 | 1,890
Tdark 2 | 7,003

IMPC Phenotype

decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
abnormal behavior 3 | 226
decreased circulating HDL chol... 3 | 77
decreased prepulse inhibition 3 | 52
increased grip strength 3 | 83
preweaning lethality, complete... 3 | 633
abnormal bone mineralization 2 | 55
abnormal locomotor activation 2 | 26
abnormal startle reflex 2 | 14
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
decreased circulating iron lev... 2 | 25
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating amylase ... 2 | 13
increased lean body mass 2 | 107
limb grasping 2 | 35
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal maxilla morphology 1 | 16
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased thermal nociceptive ... 1 | 4
enlarged spleen 1 | 26
hydrometra 1 | 13
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
prolonged QRS complex duration 1 | 2
sclerocornea 1 | 2
shortened RR interval 1 | 19
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

osteosarcoma 23 | 7,933
ovarian cancer 23 | 8,491
Cancer 20 | 2,346
Carcinoma 17 | 2,147
medulloblastoma, large-cell 12 | 6,234
glioblastoma 11 | 5,572
lung cancer 11 | 4,473
atypical teratoid / rhabdoid tumor 10 | 4,369
primitive neuroectodermal tumor 10 | 3,031
psoriasis 10 | 6,685
Breast cancer 9 | 3,098
Pick disease 9 | 1,893
malignant mesothelioma 9 | 3,163
group 3 medulloblastoma 8 | 2,254
oligodendroglioma 8 | 2,849
Leukemia 7 | 88
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
Rheumatoid Arthritis 6 | 1,170
ependymoma 6 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Intellectual disability 5 | 573
Kabuki syndrome 5 | 29
Mammary Neoplasms 5 | 410
acute quadriplegic myopathy 5 | 1,157
atypical teratoid/rhabdoid tumor 5 | 1,095
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
spina bifida 5 | 1,064
Lymphoid leukemia 4 | 69
Multiple myeloma 4 | 1,327
acute myeloid leukemia 4 | 785
astrocytic glioma 4 | 2,241
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
medulloblastoma 4 | 1,524
non-small cell lung cancer 4 | 2,798
pediatric high grade glioma 4 | 2,712
Adenocarcinoma 3 | 115
Adenoid Cystic Carcinoma 3 | 99
Alzheimer's disease 3 | 644
Colonic Neoplasms 3 | 126
Heat Stroke 3 | 12
Leukemia, Myelocytic, Acute 3 | 113
Liver carcinoma 3 | 217
MYELODYSPLASTIC SYNDROME 3 | 39
Mantle cell lymphoma 3 | 20
Melanoma 3 | 261
Myeloid Leukemia 3 | 19
adrenocortical carcinoma 3 | 1,427
astrocytoma 3 | 1,493
cystic fibrosis 3 | 1,670
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
lung adenocarcinoma 3 | 2,714
nasopharyngeal carcinoma 3 | 1,056
pilocytic astrocytoma 3 | 3,086
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,563
ulcerative colitis 3 | 2,087
Amphetamine-Related Disorders 2 | 74
Amyotrophic Lateral Sclerosis 2 | 432
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Carcinoma, Transitional Cell 2 | 31
Common variable immunodeficiency 2 | 98
Corneal staphyloma 2 | 4
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Diffuse large B-cell lymphoma 2 | 42
Endometrial Neoplasms 2 | 50
Gamma chain deficiency 2 | 7
Immune system cancer 2 | 38
Kidney Failure, Chronic 2 | 45
Kidney cancer 2 | 121
Lymphoma, Follicular 2 | 20
Male infertility 2 | 170
Migraine Disorders 2 | 26
Neoplastic Cell Transformation 2 | 81
Neurilemmoma 2 | 20
Osteoporosis 2 | 259
Renal Cell Carcinoma 2 | 199
Retinoblastoma 2 | 14
Schizophrenia 2 | 503
Sezary Syndrome 2 | 26
Shigellosis 2 | 16
Sotos syndrome 2 | 15
Sotos' syndrome 2 | 3
Squamous cell carcinoma of esophagus 2 | 82
Stomach Neoplasms 2 | 282
Waldenstrons macroglobulinemia 2 | 764
gastric cancer 2 | 436
hepatocellular carcinoma 2 | 550
interstitial cystitis 2 | 2,299
lung carcinoma 2 | 2,844
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 6 months 2 | 686

Tissue

Cardiovascular System 42 | 17,957
Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Nervous System 42 | 18,560
Skin and soft tissues 42 | 18,114
Urinary Tract 42 | 18,443
Blood and immune system 41 | 17,994
Male tissues 41 | 17,968
Respiratory system 41 | 17,483

Target Family

Epigenetic 24 | 242
Non-IDG 10 | 11,969
TF/Epigenetic 5 | 38
Transcription Factor 3 | 1,400
Enzyme 1 | 4,146

Reactome Pathway

PKMTs methylate histone lysine... 43 | 43
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Histone-lysine N-methyltransferase 2B KMT2B Tbio Epigenetic -1.88254 72.1 124
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.68453 51.8 276
Zinc finger protein AEBP2 AEBP2 Tbio Non-IDG -0.94645 9.73 91
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.25781 180.0 594
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -0.96080 10.8 171
Protein dpy-30 homolog DPY30 Tbio Non-IDG -1.28113 20.8 23
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.12684 133.9 113
N-lysine methyltransferase SMYD2 SMYD2 Tchem Epigenetic -1.59513 48.8 207
N-lysine methyltransferase KMT5A KMT5A Tchem Epigenetic -1.80375 62.5 346