Development Level

Tbio 23 | 10,625
Tchem 18 | 1,890
Tdark 2 | 7,003

IMPC Term

decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
abnormal behavior 3 | 226
decreased circulating HDL chol... 3 | 77
decreased prepulse inhibition 3 | 52
increased grip strength 3 | 83
preweaning lethality, complete... 3 | 633
abnormal bone mineralization 2 | 55
abnormal locomotor activation 2 | 26
abnormal startle reflex 2 | 14
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
decreased circulating iron lev... 2 | 25
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating amylase ... 2 | 13
increased lean body mass 2 | 107
limb grasping 2 | 35
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal maxilla morphology 1 | 16
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased thermal nociceptive ... 1 | 4
enlarged spleen 1 | 26
hydrometra 1 | 13
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
prolonged QRS complex duration 1 | 2
sclerocornea 1 | 2
shortened RR interval 1 | 19
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

osteosarcoma 23 | 7,933
ovarian cancer 23 | 8,484
Cancer 20 | 2,346
Carcinoma 17 | 2,147
medulloblastoma, large-cell 12 | 6,234
glioblastoma 11 | 5,572
lung cancer 11 | 4,466
atypical teratoid / rhabdoid tumor 10 | 4,369
primitive neuroectodermal tumor 10 | 3,031
psoriasis 10 | 6,685
Breast cancer 9 | 3,094
Pick disease 9 | 1,893
malignant mesothelioma 9 | 3,162
group 3 medulloblastoma 8 | 2,254
oligodendroglioma 8 | 2,849
Leukemia 7 | 88
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
Rheumatoid Arthritis 6 | 1,160
ependymoma 6 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Intellectual disability 5 | 573
Kabuki syndrome 5 | 27
Mammary Neoplasms 5 | 410
acute quadriplegic myopathy 5 | 1,157
atypical teratoid/rhabdoid tumor 5 | 1,095
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
spina bifida 5 | 1,064
Lymphoid leukemia 4 | 69
Multiple myeloma 4 | 1,327
astrocytic glioma 4 | 2,241
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
medulloblastoma 4 | 1,524
non-small cell lung cancer 4 | 2,798
pediatric high grade glioma 4 | 2,712
Adenocarcinoma 3 | 115
Adenoid Cystic Carcinoma 3 | 99
Alzheimer's disease 3 | 644
Colonic Neoplasms 3 | 126
Heat Stroke 3 | 12
Leukemia, Myelocytic, Acute 3 | 113
Liver carcinoma 3 | 217
MYELODYSPLASTIC SYNDROME 3 | 36
Mantle cell lymphoma 3 | 18
Melanoma 3 | 261
Myeloid Leukemia 3 | 19
acute myeloid leukemia 3 | 780
adrenocortical carcinoma 3 | 1,427
astrocytoma 3 | 1,493
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
ductal carcinoma in situ 3 | 1,745
lung adenocarcinoma 3 | 2,713
nasopharyngeal carcinoma 3 | 1,056
pilocytic astrocytoma 3 | 3,086
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,557
ulcerative colitis 3 | 2,087
Amphetamine-Related Disorders 2 | 74
Amyotrophic Lateral Sclerosis 2 | 431
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Carcinoma, Transitional Cell 2 | 31
Common variable immunodeficiency 2 | 72
Corneal staphyloma 2 | 4
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Diffuse large B-cell lymphoma 2 | 41
Endometrial Neoplasms 2 | 50
Gamma chain deficiency 2 | 7
Immune system cancer 2 | 38
Kidney Failure, Chronic 2 | 45
Kidney cancer 2 | 118
Kleefstra syndrome 2 | 9
Lymphoma, Follicular 2 | 20
Male infertility 2 | 170
Migraine Disorders 2 | 26
Neoplastic Cell Transformation 2 | 81
Neurilemmoma 2 | 20
Osteoporosis 2 | 257
Phyllodes Tumor 2 | 5
Renal Cell Carcinoma 2 | 199
Retinoblastoma 2 | 14
Sezary Syndrome 2 | 26
Shigellosis 2 | 16
Sotos' syndrome 2 | 3
Squamous cell carcinoma of esophagus 2 | 82
Stomach Neoplasms 2 | 282
Waldenstrons macroglobulinemia 2 | 765
gastric cancer 2 | 430
hepatocellular carcinoma 2 | 532
interstitial cystitis 2 | 2,299
lung carcinoma 2 | 2,844
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 6 months 2 | 686

Tissue

Cardiovascular System 42 | 17,958
Digestive Tract 42 | 18,473
Endocrine System 42 | 18,512
Female tissues 42 | 18,647
Liver and Pancreas 42 | 18,136
Nervous System 42 | 18,561
Skin and soft tissues 42 | 18,115
Urinary Tract 42 | 18,444
Blood and immune system 41 | 17,995
Male tissues 41 | 17,969
Respiratory system 41 | 17,484

Target Family

Epigenetic 24 | 242
Non-IDG 10 | 11,971
TF/Epigenetic 5 | 38
Transcription Factor 3 | 1,400
Enzyme 1 | 4,146

Reactome Pathway

PKMTs methylate histone lysine... 43 | 43
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.53375 346.3 108
Histone-lysine N-methyltransferase 2E KMT2E Tbio Epigenetic -1.45323 38.7 150
Zinc finger protein AEBP2 AEBP2 Tbio Non-IDG -0.95067 9.73 91
Histone-lysine N-methyltransferase KMT5C KMT5C Tdark Epigenetic 1.18 0.06 42
Histone-lysine N-methyltransferase SETD2 SETD2 Tchem Epigenetic -2.76087 585.6 192
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.18679 149.4 267
Histone-lysine N-methyltransferase SETD7 SETD7 Tchem Epigenetic -2.08116 127.0 297
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.41218 3.66 84
MDS1 and EVI1 complex locus protein MDS1 MECOM Tbio Non-IDG 115.2 0