Development Level

Tbio 166 | 11,445
Tchem 51 | 1,598
Tclin 37 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to t... 10 | 278
abnormal embryo size 8 | 220
increased total body fat amoun... 7 | 134
preweaning lethality, incomple... 7 | 499
decreased body weight 6 | 161
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
decreased lean body mass 5 | 135
embryonic lethality prior to o... 5 | 239
enlarged heart 5 | 210
increased lean body mass 5 | 172
abnormal heart morphology 4 | 162
hypoactivity 4 | 132
increased circulating choleste... 4 | 66
increased mean corpuscular hem... 4 | 96
increased startle reflex 4 | 112
limb grasping 4 | 41
abnormal retinal vasculature m... 3 | 27
cataract 3 | 92
decreased caudal vertebrae num... 3 | 53
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased erythrocyte cell num... 3 | 62
decreased heart left ventricle... 3 | 28
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased prepulse inhibition 3 | 82
decreased total body fat amoun... 3 | 207
edema 3 | 59
embryonic growth retardation 3 | 106
increased circulating alkaline... 3 | 122
increased hemoglobin content 3 | 45
male infertility 3 | 123
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal startle reflex 2 | 15
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased threshold for audito... 2 | 26
decreased vertical activity 2 | 208
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating amylase ... 2 | 25
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
prenatal lethality prior to he... 2 | 87
small spleen 2 | 19
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
decreased T cell number 1 | 15
decreased circulating chloride... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased mean corpuscular hem... 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
iris synechia 1 | 3
long tibia 1 | 25
microphthalmia 1 | 26
prenatal lethality 1 | 28
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 174 | 11,493
ovarian cancer 155 | 8,520
osteosarcoma 130 | 7,950
Cancer 123 | 2,499
psoriasis 110 | 6,694
lung cancer 104 | 4,740
glioblastoma 101 | 5,792
medulloblastoma, large-cell 100 | 6,241
Breast cancer 77 | 3,578
atypical teratoid / rhabdoid tumor 76 | 5,112
ependymoma 61 | 4,679
malignant mesothelioma 58 | 3,232
group 3 medulloblastoma 54 | 4,104
adult high grade glioma 53 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
invasive ductal carcinoma 52 | 2,951
Kidney cancer 48 | 2,613
non-small cell lung cancer 47 | 2,890
subependymal giant cell astrocytoma 47 | 2,287
Multiple myeloma 45 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
diabetes mellitus 43 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
oligodendroglioma 43 | 2,850
interstitial cystitis 42 | 2,312
lung adenocarcinoma 40 | 2,716
Schizophrenia 39 | 1,160
breast carcinoma 37 | 1,638
Astrocytoma, Pilocytic 36 | 3,081
group 4 medulloblastoma 36 | 1,855
lung carcinoma 36 | 2,843
pancreatic cancer 36 | 2,398
tuberculosis 36 | 2,010
ulcerative colitis 36 | 1,819
astrocytic glioma 35 | 2,597
Rheumatoid arthritis 33 | 1,191
Autosomal recessive predisposition 32 | 1,442
ductal carcinoma in situ 32 | 1,745
pituitary cancer 32 | 1,972
primitive neuroectodermal tumor 32 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
Breast Neoplasms 30 | 445
Mammary Neoplasms 30 | 425
astrocytoma 28 | 1,146
Prostatic Neoplasms 27 | 495
cystic fibrosis 27 | 1,696
Bipolar Disorder 25 | 666
Pick disease 25 | 1,894
dermatomyositis 24 | 966
juvenile dermatomyositis 24 | 1,187
Alzheimer's disease 23 | 658
Vascular disease 23 | 319
adrenocortical carcinoma 23 | 1,428
cutaneous lupus erythematosus 23 | 1,057
Epilepsy 22 | 792
Stomach Neoplasms 22 | 300
Lung Neoplasms 21 | 232
Osteoporosis 21 | 363
Obesity 20 | 678
Seizures 20 | 596
Waldenstrons macroglobulinemia 20 | 765
colon cancer 20 | 1,478
Carcinoma, Hepatocellular 19 | 228
Liver carcinoma 19 | 240
Depressive disorder 18 | 409
HIV Infections 18 | 102
Intellectual disability 18 | 1,016
Kidney disease 18 | 430
Liver Cirrhosis, Experimental 18 | 769
acute quadriplegic myopathy 18 | 1,158
non primary Sjogren syndrome sicca 18 | 891
primary Sjogren syndrome 18 | 735
Carcinoma, Squamous Cell 17 | 110
Renal Cell Carcinoma 17 | 214
Squamous cell carcinoma 17 | 129
Endometriosis 16 | 540
Polycystic ovary syndrome 16 | 360
pediatric high grade glioma 16 | 1,064
spina bifida 16 | 1,074
Asthma 15 | 385
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Melanoma 15 | 711
Mental and motor retardation 15 | 608
Neoplasm Invasiveness 15 | 161
Neoplasm Metastasis 15 | 168
Orbital separation excessive 15 | 244
Cleft Palate 14 | 271
Ovarian Neoplasms 14 | 102
Parkinson's disease 14 | 392
Skin cancer 14 | 469
acute myeloid leukemia 14 | 783
gastric carcinoma 14 | 807
primary pancreatic ductal adenocarcinoma 14 | 1,109
Arthritis 13 | 290
Dull intelligence 13 | 645
Mental Depression 13 | 333
Mental deficiency 13 | 645
Poor school performance 13 | 645
fibroadenoma 13 | 559

Tissue

Endocrine System 256 | 18,159
Digestive Tract 253 | 17,369
Urinary Tract 253 | 16,678
Female tissues 252 | 17,400
Nervous System 252 | 16,725
Skin and soft tissues 252 | 17,230
Blood and immune system 251 | 16,909
Male tissues 251 | 17,142
Liver and Pancreas 250 | 16,750
Respiratory system 250 | 16,393
Cardiovascular System 243 | 15,192

Target Family

Non-IDG 98 | 12,091
Enzyme 78 | 4,145
Kinase 44 | 634
Transcription Factor 18 | 1,400
Epigenetic 14 | 242
Nuclear Receptor 5 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

Reactome Pathway

PIP3 activates AKT signaling 259 | 259
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203