Development Level

Tbio 52 | 11,445
Tclin 23 | 613
Tchem 20 | 1,598

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal embryo size 4 | 220
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal behavior 2 | 298
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
increased hemoglobin content 2 | 45
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
male infertility 1 | 123
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
thin ventricular wall 1 | 24

Disease

Carcinoma 68 | 11,493
Cancer 59 | 2,499
osteosarcoma 50 | 7,950
ovarian cancer 48 | 8,520
lung cancer 46 | 4,740
psoriasis 45 | 6,694
glioblastoma 42 | 5,792
medulloblastoma, large-cell 42 | 6,241
Breast cancer 37 | 3,578
atypical teratoid / rhabdoid tumor 33 | 5,112
malignant mesothelioma 33 | 3,232
interstitial cystitis 32 | 2,312
invasive ductal carcinoma 30 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
non-small cell lung cancer 26 | 2,890
ependymoma 25 | 4,679
lung carcinoma 25 | 2,843
adult high grade glioma 24 | 3,801
ulcerative colitis 24 | 1,819
Schizophrenia 23 | 1,160
group 3 medulloblastoma 23 | 4,104
lung adenocarcinoma 23 | 2,716
Astrocytoma, Pilocytic 22 | 3,081
Kidney cancer 22 | 2,613
Autosomal recessive predisposition 21 | 1,442
breast carcinoma 21 | 1,638
diabetes mellitus 21 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
cystic fibrosis 19 | 1,696
ductal carcinoma in situ 19 | 1,745
pancreatic cancer 19 | 2,398
pituitary cancer 19 | 1,972
subependymal giant cell astrocytoma 19 | 2,287
Rheumatoid arthritis 18 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
oligodendroglioma 18 | 2,850
tuberculosis 18 | 2,010
astrocytic glioma 17 | 2,597
cutaneous lupus erythematosus 17 | 1,057
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
Bipolar Disorder 15 | 666
Prostatic Neoplasms 15 | 495
Stomach Neoplasms 15 | 300
Lung Neoplasms 14 | 232
Depressive disorder 13 | 409
group 4 medulloblastoma 13 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Carcinoma, Hepatocellular 12 | 228
Cleft Palate 12 | 271
Kidney disease 12 | 430
Liver Cirrhosis, Experimental 12 | 769
Liver carcinoma 12 | 240
Osteoporosis 12 | 363
Renal Cell Carcinoma 12 | 214
adrenocortical carcinoma 12 | 1,428
Neoplasm Invasiveness 11 | 161
Orbital separation excessive 11 | 244
Seizures 11 | 596
Vascular disease 11 | 319
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
primary Sjogren syndrome 11 | 735
primitive neuroectodermal tumor 11 | 3,035
Alzheimer's disease 10 | 658
Arthritis 10 | 290
Asthma 10 | 385
Cognitive delay 10 | 608
Downward slant of palpebral fissure 10 | 158
Epilepsy 10 | 792
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Neoplasm Metastasis 10 | 168
Obesity 10 | 678
spina bifida 10 | 1,074
Adenocarcinoma 9 | 122
Cleft Lip 9 | 141
Diarrhea 9 | 253
Disease Progression 9 | 136
Fetal Growth Retardation 9 | 189
Heart disease 9 | 306
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Lung disease 9 | 142
fibroadenoma 9 | 559
gastric carcinoma 9 | 807
Delayed bone age 8 | 136
Endometriosis 8 | 540
Hypoplastic mandible condyle 8 | 275
Immunologic Deficiency Syndromes 8 | 113
Mandibular hypoplasia 8 | 275
Mental Depression 8 | 333
Micrognathism 8 | 275
Ovarian Neoplasms 8 | 102
Polycystic ovary syndrome 8 | 360
Skin cancer 8 | 469
Somatic mutation 8 | 61
Squamous cell carcinoma 8 | 129
juvenile dermatomyositis 8 | 1,187
nasopharyngeal carcinoma 8 | 1,058

Tissue

Endocrine System 94 | 18,159
Digestive Tract 93 | 17,369
Female tissues 92 | 17,400
Skin and soft tissues 92 | 17,230
Urinary Tract 92 | 16,678
Blood and immune system 91 | 16,909
Liver and Pancreas 91 | 16,750
Male tissues 91 | 17,142
Nervous System 91 | 16,725
Respiratory system 90 | 16,393
Cardiovascular System 85 | 15,192

Target Family

Non-IDG 47 | 12,091
Kinase 30 | 634
Enzyme 16 | 4,145
Nuclear Receptor 2 | 48

Reactome Pathway

PI5P, PP2A and IER3 Regulate P... 95 | 95
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Interleukin-1 receptor-like 1 IL1RL1 Tbio Non-IDG -2.06895 107.0 347
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162
Beta-klotho KLB Tbio Enzyme -2.02643 82.8 95
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Phosphoinositide 3-kinase adapter protein 1 PIK3AP1 Tbio Enzyme -0.26163 1.48 198