Development Level

Tbio 8 | 11,445
Tclin 4 | 613
Tchem 3 | 1,598

IMPC Phenotype

decreased leukocyte cell numbe... 1 | 73
preweaning lethality, complete... 1 | 979

Disease

Breast cancer 11 | 3,578
Cancer 11 | 2,499
Carcinoma 11 | 11,493
glioblastoma 11 | 5,792
lung cancer 10 | 4,740
medulloblastoma, large-cell 10 | 6,241
Kidney cancer 9 | 2,613
atypical teratoid / rhabdoid tumor 9 | 5,112
interstitial cystitis 9 | 2,312
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
ovarian cancer 8 | 8,520
Schizophrenia 7 | 1,160
lung adenocarcinoma 7 | 2,716
pancreatic cancer 7 | 2,398
Autosomal recessive predisposition 6 | 1,442
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Rheumatoid arthritis 6 | 1,191
ependymoma 6 | 4,679
invasive ductal carcinoma 6 | 2,951
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Disease Progression 5 | 136
Lung Neoplasms 5 | 232
Neoplasm Metastasis 5 | 168
Prostatic Neoplasms 5 | 495
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
non-small cell lung cancer 5 | 2,890
pituitary cancer 5 | 1,972
Adenocarcinoma 4 | 122
Bipolar Disorder 4 | 666
Endometriosis 4 | 540
Gallbladder Neoplasms 4 | 10
HER2-positive carcinoma of breast 4 | 21
Ovarian Neoplasms 4 | 102
Stomach Neoplasms 4 | 300
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
fibroadenoma 4 | 559
gallbladder neoplasm 4 | 10
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074
Adenoma 3 | 167
Alcoholic Intoxication, Chronic 3 | 289
Animal Mammary Neoplasms 3 | 136
Arthritis, Juvenile 3 | 126
Bronchioloalveolar Adenocarcinoma 3 | 14
Carcinoma, Hepatocellular 3 | 228
DOID:2627 3 | 94
Depressive disorder 3 | 409
Diarrhea 3 | 253
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Fatigue 3 | 182
Hypoplastic mandible condyle 3 | 275
Juvenile arthritis 3 | 126
Liver cancer 3 | 604
Liver carcinoma 3 | 240
Major Depressive Disorder 3 | 301
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Mandibular hypoplasia 3 | 275
Melanoma 3 | 711
Micrognathism 3 | 275
Neoplasm Invasiveness 3 | 161
Non-small cell lung cancer, positive for epidermal growth factor receptor expression 3 | 4
Papilloma 3 | 44
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
Skin cancer 3 | 469
Unipolar Depression 3 | 250
gastric cancer 3 | 459
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
ovarian neoplasm 3 | 99
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Colonic Neoplasms 2 | 142
Dermatitis 2 | 157
Esophageal carcinoma 2 | 16
Heart disease 2 | 306
Kidney disease 2 | 430
Recurrence 2 | 33
Reperfusion Injury 2 | 86
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 9 | 12,091
Kinase 6 | 634

Reactome Pathway

PI3K events in ERBB2 signaling 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Pro-neuregulin-3, membrane-bound isoform NRG3 Tbio Non-IDG -1.56404 39.4 165
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859