Development Level

Tbio 3 | 11,651
Tchem 3 | 1,388
Tclin 2 | 612

IMPC Phenotype

decreased circulating creatini... 2 | 39
decreased body weight 1 | 161
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 8 | 11,493
Cancer 7 | 2,499
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
Schizophrenia 4 | 1,160
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Breast cancer 3 | 3,578
Cognitive delay 3 | 608
Frontal bossing 3 | 157
Global developmental delay 3 | 608
Infantile onset 3 | 238
Intellectual disability 3 | 1,016
Mental and motor retardation 3 | 608
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Stomach Neoplasms 3 | 300
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
glioblastoma 3 | 5,792
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
Absence of pain sensation 2 | 5
Acral ulceration and osteomyelitis leading to autoamputation 2 | 4
Alzheimer's disease 2 | 658
Anhidrosis 2 | 23
Asthma 2 | 385
Big calvaria 2 | 147
Carcinoma, Hepatocellular 2 | 228
Cataract 2 | 297
Cerebrovascular disease 2 | 238
Concave bridge of nose 2 | 195
Congenital Pain Insensitivity 2 | 6
Corneal Ulcer 2 | 21
DOID:2627 2 | 94
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Depressive disorder 2 | 409
Diffuse large B-cell lymphoma 2 | 39
Dull intelligence 2 | 645
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fatigue 2 | 182
Hereditary Sensory Autonomic Neuropathy, Type 5 2 | 5
Hereditary Sensory and Autonomic Neuropathies 2 | 4
High forehead 2 | 102
Hyperactive behavior 2 | 91
Hyperglycemia 2 | 137
Hyperkyphosis 2 | 111
Hypoplastic mandible condyle 2 | 275
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Infection of bone 2 | 19
Insulin Resistance 2 | 72
Irritation - emotion 2 | 68
Joint laxity 2 | 54
Kidney cancer 2 | 2,613
Kyphosis deformity of spine 2 | 114
Lens Opacities 2 | 231
Lewy Body Disease 2 | 21
Liver carcinoma 2 | 240
Low intelligence 2 | 645
Lung Injury 2 | 20
Lymphoma, Large B-Cell, Diffuse 2 | 34
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Micrognathism 2 | 275
Microstomia 2 | 78
Myopia 2 | 176
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Osteomyelitis 2 | 42
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Polymicrogyria 2 | 48
Poor school performance 2 | 645
Self Mutilation 2 | 14
Skin Ulcer 2 | 48
Syndactyly 2 | 88
Tall forehead 2 | 102
Telecanthus 2 | 62
Toxic encephalopathy 2 | 141
Ventricular Septal Defects 2 | 119
Waldenstrons macroglobulinemia 2 | 765
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
primitive neuroectodermal tumor 2 | 3,035

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Kinase 4 | 634
Enzyme 2 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

PI3K/AKT activation 8 | 8
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 Tbio Enzyme -1.80666 60.0 432
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484