Development Level

Tbio 66 | 10,625
Tchem 39 | 1,890
Tclin 22 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 3 | 157
decreased kidney weight 3 | 7
decreased lean body mass 3 | 195
enlarged heart 3 | 111
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
impaired pupillary reflex 2 | 14
increased circulating LDL chol... 2 | 15
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased leukocyte cell numbe... 1 | 54
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
prenatal lethality prior to he... 1 | 64
prolonged QRS complex duration 1 | 2
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

Cancer 79 | 2,346
osteosarcoma 77 | 7,933
ovarian cancer 66 | 8,492
psoriasis 62 | 6,685
medulloblastoma, large-cell 56 | 6,234
lung cancer 49 | 4,473
glioblastoma 48 | 5,572
Breast cancer 42 | 3,099
atypical teratoid / rhabdoid tumor 38 | 4,369
invasive ductal carcinoma 36 | 2,950
diabetes mellitus 32 | 1,663
Carcinoma 31 | 2,147
interstitial cystitis 31 | 2,299
malignant mesothelioma 31 | 3,163
subependymal giant cell astrocytoma 30 | 2,287
ulcerative colitis 29 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
non-small cell lung cancer 28 | 2,798
oligodendroglioma 27 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
lung adenocarcinoma 25 | 2,714
pituitary cancer 25 | 1,972
ependymoma 24 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
pancreatic cancer 24 | 2,300
ductal carcinoma in situ 22 | 1,745
lung carcinoma 22 | 2,844
pediatric high grade glioma 22 | 2,712
pilocytic astrocytoma 22 | 3,086
Mammary Neoplasms 21 | 410
Prostatic Neoplasms 21 | 471
Rheumatoid Arthritis 21 | 1,171
breast carcinoma 21 | 1,614
cystic fibrosis 21 | 1,670
group 4 medulloblastoma 20 | 1,875
tuberculosis 20 | 1,563
astrocytic glioma 19 | 2,241
group 3 medulloblastoma 19 | 2,254
Alzheimer's disease 18 | 644
Schizophrenia 18 | 503
Pick disease 17 | 1,893
cutaneous lupus erythematosus 17 | 1,056
Lung Neoplasms 16 | 171
adult high grade glioma 16 | 2,148
juvenile dermatomyositis 16 | 1,189
primitive neuroectodermal tumor 16 | 3,031
Kidney disease 15 | 397
Liver carcinoma 15 | 217
Stomach Neoplasms 15 | 282
Vascular disease 15 | 281
medulloblastoma 15 | 1,524
Obesity 14 | 616
adrenocortical carcinoma 14 | 1,427
colon cancer 14 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Renal Cell Carcinoma 13 | 199
spina bifida 13 | 1,064
Asthma 12 | 349
Cleft palate 12 | 125
Parkinson's disease 12 | 364
Polycystic Ovary Syndrome 12 | 335
astrocytoma 12 | 1,493
pancreatic carcinoma 12 | 567
primary Sjogren syndrome 12 | 789
primary pancreatic ductal adenocarcinoma 12 | 1,271
Neoplasm Invasiveness 11 | 127
acute quadriplegic myopathy 11 | 1,157
atypical teratoid/rhabdoid tumor 11 | 1,095
fibroadenoma 11 | 557
nasopharyngeal carcinoma 11 | 1,056
non-small cell lung carcinoma 11 | 413
ovarian neoplasm 11 | 97
Adenoma 10 | 165
Down syndrome 10 | 548
Kidney cancer 10 | 121
Squamous cell carcinoma 10 | 96
gastric carcinoma 10 | 832
posterior fossa group B ependymoma 10 | 1,530
Adenocarcinoma 9 | 115
Bipolar Disorder 9 | 266
Cleft Lip 9 | 91
Heart disease 9 | 279
Insulin Resistance 9 | 50
Intellectual disability 9 | 573
Lung disease 9 | 136
Multiple myeloma 9 | 1,328
Toxic encephalopathy 9 | 131
tuberculosis and treatment for 6 months 9 | 686
Amyotrophic Lateral Sclerosis 8 | 432
Craniosynostosis 8 | 47
Endometriosis 8 | 535
Hamman-Rich syndrome 8 | 35
Neoplasm Metastasis 8 | 138
Reperfusion Injury 8 | 84
gastric cancer 8 | 436
hepatocellular carcinoma 8 | 550
posterior fossa group A ependymoma 8 | 1,511
progressive supranuclear palsy 8 | 674
dermatomyositis 7 | 967
esophageal adenocarcinoma 7 | 737

Tissue

Endocrine System 128 | 18,512
Female tissues 128 | 18,647
Nervous System 128 | 18,561
Digestive Tract 127 | 18,473
Liver and Pancreas 127 | 18,136
Skin and soft tissues 127 | 18,115
Urinary Tract 127 | 18,444
Blood and immune system 126 | 17,995
Cardiovascular System 126 | 17,958
Male tissues 125 | 17,969
Respiratory system 121 | 17,484

Target Family

Non-IDG 57 | 11,969
Kinase 39 | 634
Enzyme 26 | 4,146
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

PI3K/AKT activation 128 | 128
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha PIP5K1A Tbio Kinase -0.55632 4.98 106
Protein argonaute-4 AGO4 Tbio Non-IDG -1.38945 21.8 85
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.62322 398.1 207
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.52177 33.8 100
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.51668 46.0 252
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.33263 203.3 303
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.64445 3.33 246
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.99634 1000.8 1343
Beta-nerve growth factor NGF Tchem Non-IDG -4.00388 10626.8 510
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.24522 1684.0 357