Development Level

Tbio 49 | 11,445
Tclin 24 | 613
Tchem 19 | 1,598

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
increased total body fat amoun... 4 | 134
decreased body weight 3 | 161
decreased lean body mass 3 | 135
enlarged heart 3 | 210
increased circulating choleste... 3 | 66
increased mean corpuscular hem... 3 | 96
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased total body fat amoun... 2 | 207
impaired pupillary reflex 2 | 26
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased hemoglobin content 2 | 45
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
anophthalmia 1 | 33
cleft palate 1 | 8
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased body length 1 | 32
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
male infertility 1 | 123
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Cancer 68 | 2,499
Carcinoma 66 | 11,493
osteosarcoma 51 | 7,950
psoriasis 49 | 6,694
ovarian cancer 47 | 8,520
lung cancer 43 | 4,740
Breast cancer 37 | 3,578
medulloblastoma, large-cell 35 | 6,241
glioblastoma 33 | 5,792
malignant mesothelioma 30 | 3,232
invasive ductal carcinoma 29 | 2,951
Kidney cancer 28 | 2,613
interstitial cystitis 28 | 2,312
atypical teratoid / rhabdoid tumor 27 | 5,112
diabetes mellitus 23 | 1,728
ependymoma 23 | 4,679
Schizophrenia 22 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
non-small cell lung cancer 22 | 2,890
Breast Neoplasms 21 | 445
Mammary Neoplasms 21 | 425
group 3 medulloblastoma 21 | 4,104
subependymal giant cell astrocytoma 21 | 2,287
ulcerative colitis 21 | 1,819
Autosomal recessive predisposition 20 | 1,442
breast carcinoma 20 | 1,638
lung adenocarcinoma 20 | 2,716
cystic fibrosis 19 | 1,696
ductal carcinoma in situ 19 | 1,745
pituitary cancer 19 | 1,972
Prostatic Neoplasms 18 | 495
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
tuberculosis 18 | 2,010
Astrocytoma, Pilocytic 17 | 3,081
Bipolar Disorder 17 | 666
adult high grade glioma 17 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
lung carcinoma 17 | 2,843
Rheumatoid arthritis 16 | 1,191
cutaneous lupus erythematosus 16 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Depressive disorder 15 | 409
group 4 medulloblastoma 15 | 1,855
Carcinoma, Hepatocellular 14 | 228
Liver carcinoma 14 | 240
Stomach Neoplasms 14 | 300
Cleft Palate 13 | 271
Lung Neoplasms 13 | 232
Vascular disease 13 | 319
astrocytoma 13 | 1,146
colon cancer 13 | 1,478
Alzheimer's disease 12 | 658
Epilepsy 12 | 792
Obesity 12 | 678
Renal Cell Carcinoma 12 | 214
astrocytic glioma 12 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Diarrhea 11 | 253
Liver Cirrhosis, Experimental 11 | 769
Seizures 11 | 596
adrenocortical carcinoma 11 | 1,428
juvenile dermatomyositis 11 | 1,187
spina bifida 11 | 1,074
Adenocarcinoma 10 | 122
Kidney disease 10 | 430
Cleft Lip 9 | 141
Mental Depression 9 | 333
Orbital separation excessive 9 | 244
Osteoporosis 9 | 363
Pick disease 9 | 1,894
Polycystic ovary syndrome 9 | 360
Somatic mutation 9 | 61
fibroadenoma 9 | 559
nasopharyngeal carcinoma 9 | 1,058
primary Sjogren syndrome 9 | 735
Downward slant of palpebral fissure 8 | 158
Endometriosis 8 | 540
Hepatomegaly 8 | 285
Hypoplastic mandible condyle 8 | 275
Major Depressive Disorder 8 | 301
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Neoplasm Invasiveness 8 | 161
Neoplasm Metastasis 8 | 168
Ovarian Neoplasms 8 | 102
Parkinson's disease 8 | 392
Skin cancer 8 | 469
gastric carcinoma 8 | 807
non-small cell lung carcinoma 8 | 317
pancreatic carcinoma 8 | 562
primitive neuroectodermal tumor 8 | 3,035
Atopic dermatitis 7 | 952
Craniosynostosis 7 | 74
Delayed bone age 7 | 136
Down syndrome 7 | 499
acute quadriplegic myopathy 7 | 1,158
hepatocellular carcinoma 7 | 547
pediatric high grade glioma 7 | 1,064
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Endocrine System 91 | 18,159
Digestive Tract 90 | 17,369
Female tissues 89 | 17,400
Male tissues 89 | 17,142
Skin and soft tissues 89 | 17,230
Urinary Tract 89 | 16,678
Blood and immune system 88 | 16,909
Liver and Pancreas 88 | 16,750
Nervous System 88 | 16,725
Respiratory system 87 | 16,393
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 47 | 12,091
Kinase 27 | 634
Enzyme 11 | 4,145
Transcription Factor 4 | 1,400
Nuclear Receptor 3 | 48

Reactome Pathway

PI3K/AKT Signaling in Cancer 92 | 92
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Beta-klotho KLB Tbio Enzyme -2.02643 82.8 95
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720