Development Level

Tbio 13 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
cleft palate 1 | 8
decreased bone mineral content 1 | 151
decreased hematocrit 1 | 46
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
increased body length 1 | 32
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
limb grasping 1 | 41

Disease

Cancer 12 | 2,499
Carcinoma 10 | 11,493
psoriasis 9 | 6,694
lung cancer 8 | 4,740
ovarian cancer 8 | 8,520
medulloblastoma, large-cell 7 | 6,241
osteosarcoma 7 | 7,950
Breast cancer 6 | 3,578
diabetes mellitus 6 | 1,728
glioblastoma 6 | 5,792
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
Depressive disorder 5 | 409
atypical teratoid / rhabdoid tumor 5 | 5,112
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
lung adenocarcinoma 5 | 2,716
Autosomal recessive predisposition 4 | 1,442
Cleft Palate 4 | 271
Delayed bone age 4 | 136
Kidney cancer 4 | 2,613
Parkinson's disease 4 | 392
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Adenocarcinoma 3 | 122
Adenoid Cystic Carcinoma 3 | 99
Anxiety 3 | 136
Anxiety disease 3 | 113
Carcinoma, Adenoid Cystic 3 | 99
Carcinoma, Hepatocellular 3 | 228
Cleft Lip 3 | 141
Congenital Epicanthus 3 | 177
Congenital hypoplasia of ovary 3 | 30
Congenital hypoplasia of penis 3 | 176
Cryptorchidism 3 | 296
Decreased fertility 3 | 33
Delayed Puberty 3 | 97
Down syndrome 3 | 499
Fatigue 3 | 182
Gynecomastia 3 | 64
Hypogonadism, Isolated Hypogonadotropic 3 | 71
Hypogonadotropic hypogonadism 3 | 89
Hypoplastic mandible condyle 3 | 275
Hypoplastic ovary 3 | 30
Liver carcinoma 3 | 240
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Myopia 3 | 176
Orbital separation excessive 3 | 244
Osteoporosis 3 | 363
Polydactyly 3 | 107
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Sense of smell impaired 3 | 21
Synostosis 3 | 15
Wide spaced nipples 3 | 46
astrocytic glioma 3 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
pancreatic cancer 3 | 2,398
ulcerative colitis 3 | 1,819
Abnormality of cardiovascular system morphology 2 | 23
Abnormality of the voice 2 | 46
Acquired scoliosis 2 | 281
Adenoma 2 | 167
Breast Neoplasms 2 | 445
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Congenital heart disease 2 | 93
Craniosynostosis 2 | 74
Curvature of spine 2 | 282
DOID:2627 2 | 94
Diarrhea 2 | 253
Disease Progression 2 | 136
Downward slant of palpebral fissure 2 | 158
Endometrial cancer 2 | 311
Failure to gain weight 2 | 365
Frontal bossing 2 | 157
Gaucher disease type 1 2 | 180
High forehead 2 | 102
Joint hyperflexibility 2 | 78
Klinefelter's syndrome 2 | 56
Leukemia 2 | 104
Lung Neoplasms 2 | 232
Mammary Neoplasms 2 | 425
Mesothelioma, Malignant 2 | 105
Muscle Weakness 2 | 170
Nasal bridge wide 2 | 236
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Polycystic ovary syndrome 2 | 360
Secondary physiologic amenorrhea 2 | 32
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Tall forehead 2 | 102
Triangular face 2 | 58
Ventricular Septal Defects 2 | 119
tuberculosis 2 | 2,010

Tissue

Endocrine System 19 | 18,159
Digestive Tract 18 | 17,369
Nervous System 18 | 16,725
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678
Blood and immune system 16 | 16,909
Cardiovascular System 15 | 15,192
Respiratory system 15 | 16,393

Target Family

Non-IDG 14 | 12,091
Kinase 3 | 634
Enzyme 2 | 4,145

Reactome Pathway

PI-3K cascade:FGFR4 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
Beta-klotho KLB Tbio Enzyme -2.02643 82.8 95
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162
Fibroblast growth factor 20 FGF20 Tbio Non-IDG -1.71980 55.3 117
Fibroblast growth factor 23 FGF23 Tbio Non-IDG -3.19500 1726.4 296
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.44255 276.4 502
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Fibroblast growth factor 6 FGF6 Tbio Non-IDG -1.56137 40.2 113