Development Level

Tbio 11 | 10,625
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Phenotype

embryonic lethality prior to t... 3 | 187
preweaning lethality, complete... 3 | 633
decreased bone mineral content 2 | 157
abnormal body wall morphology 1 | 7
abnormal embryo size 1 | 112
abnormal motor learning 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
cataract 1 | 26
cleft palate 1 | 6
decreased kidney weight 1 | 7
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
immune system phenotype 1 | 17
increased startle reflex 1 | 38
limb grasping 1 | 35

Disease

Cancer 12 | 2,346
ovarian cancer 9 | 8,491
psoriasis 9 | 6,685
lung cancer 8 | 4,473
medulloblastoma, large-cell 8 | 6,234
osteosarcoma 8 | 7,933
invasive ductal carcinoma 7 | 2,950
Breast cancer 6 | 3,098
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
non-small cell lung cancer 6 | 2,798
atypical teratoid / rhabdoid tumor 5 | 4,369
breast carcinoma 5 | 1,614
glioblastoma 5 | 5,572
group 3 medulloblastoma 5 | 2,254
lung adenocarcinoma 5 | 2,714
Down syndrome 4 | 548
Parkinson's disease 4 | 364
ependymoma 4 | 2,514
malignant mesothelioma 4 | 3,163
oligodendroglioma 4 | 2,849
Adenoid Cystic Carcinoma 3 | 99
Carcinoma 3 | 2,147
Cleft Lip 3 | 91
Cleft palate 3 | 125
Craniosynostosis 3 | 47
Liver carcinoma 3 | 217
Prostatic Neoplasms 3 | 471
Synostosis 3 | 18
cystic fibrosis 3 | 1,670
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
juvenile dermatomyositis 3 | 1,189
pancreatic cancer 3 | 2,300
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 2,087
Achondroplasia 2 | 20
Adenocarcinoma 2 | 115
Adenoma 2 | 165
Diaphragmatic Hernia 2 | 40
Endometrial cancer 2 | 32
Gaucher disease type 1 2 | 171
Heart disease 2 | 279
Hypogonadotropic hypogonadism 2 | 20
Irritable bowel syndrome 2 | 59
Kallmann Syndrome 2 | 33
Kidney cancer 2 | 121
Klinefelter's syndrome 2 | 59
LADD syndrome 2 | 9
Leukemia 2 | 88
Lung Neoplasms 2 | 171
Mammary Neoplasms 2 | 410
Mesothelioma 2 | 40
Myocardial Ischemia 2 | 169
Noonan Syndrome 2 | 33
Pick disease 2 | 1,893
Polycystic Ovary Syndrome 2 | 334
Polydactyly 2 | 93
Pulmonary Fibrosis 2 | 66
Rheumatoid Arthritis 2 | 1,170
Vascular disease 2 | 281
Weight Gain 2 | 87
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
colon cancer 2 | 1,475
dermatomyositis 2 | 966
fibroadenoma 2 | 557
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
primitive neuroectodermal tumor 2 | 3,031
progressive supranuclear palsy 2 | 674
tuberculosis 2 | 1,563
Adenocarcinoma Of Esophagus 1 | 14
Adenocarcinoma of lung (disorder) 1 | 48
Breast adenocarcinoma 1 | 8
CHARGE syndrome 1 | 23
Cowden disease 1 | 20
Diffuse large B-cell lymphoma 1 | 42
Gastric Cancer, Hereditary Diffuse 1 | 12
Gastrointestinal system disease 1 | 50
Hamman-Rich syndrome 1 | 35
Hemangioma 1 | 35
Hypertrophic Cardiomyopathy 1 | 56
Hypotension 1 | 53
Insulin Resistance 1 | 50
Mouth Neoplasms 1 | 44
Neoplasm of stomach 1 | 11
Neurofibromatosis 1 | 37
Ollier disease 1 | 15
Opitz-GBBB syndrome 1 | 19
Penile Neoplasms 1 | 4
Type 1 diabetes mellitus 1 | 104
Uremia 1 | 19

Tissue

Digestive Tract 20 | 18,472
Endocrine System 20 | 18,511
Female tissues 20 | 18,646
Nervous System 20 | 18,560
Skin and soft tissues 20 | 18,114
Urinary Tract 20 | 18,443
Liver and Pancreas 19 | 18,135
Blood and immune system 18 | 17,994
Cardiovascular System 18 | 17,957
Male tissues 17 | 17,968
Respiratory system 16 | 17,483

Target Family

Non-IDG 15 | 11,969
Kinase 3 | 634
Enzyme 2 | 4,146

Reactome Pathway

PI-3K cascade:FGFR4 20 | 20
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-klotho KLB Tbio Enzyme -1.95818 69.9 47
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.74106 54.5 120
Fibroblast growth factor 1 FGF1 Tchem Non-IDG -3.19895 1583.2 445
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.40965 255.8 442
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.00519 933.5 424
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.99298 10115.4 658
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.08398 1308.8 971
Fibroblast growth factor 6 FGF6 Tbio Non-IDG -1.55802 39.3 91
Fibroblast growth factor 4 FGF4 Tchem Non-IDG -2.59278 381.0 264
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.49806 301.3 641