Development Level

Tbio 11 | 10,625
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Term

embryonic lethality prior to t... 3 | 187
preweaning lethality, complete... 3 | 633
decreased bone mineral content 2 | 157
abnormal body wall morphology 1 | 7
abnormal embryo size 1 | 112
abnormal motor learning 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
cataract 1 | 26
cleft palate 1 | 6
decreased kidney weight 1 | 7
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
immune system phenotype 1 | 17
increased startle reflex 1 | 38
limb grasping 1 | 35

Disease

Cancer 12 | 2,346
psoriasis 9 | 6,685
lung cancer 8 | 4,466
medulloblastoma, large-cell 8 | 6,234
osteosarcoma 8 | 7,933
ovarian cancer 8 | 8,484
invasive ductal carcinoma 7 | 2,950
Breast cancer 6 | 3,094
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
non-small cell lung cancer 6 | 2,798
atypical teratoid / rhabdoid tumor 5 | 4,369
breast carcinoma 5 | 1,614
glioblastoma 5 | 5,572
group 3 medulloblastoma 5 | 2,254
lung adenocarcinoma 5 | 2,713
Down syndrome 4 | 548
Parkinson's disease 4 | 364
ependymoma 4 | 2,514
malignant mesothelioma 4 | 3,162
oligodendroglioma 4 | 2,849
Adenoid Cystic Carcinoma 3 | 99
Carcinoma 3 | 2,147
Cleft Lip 3 | 91
Cleft palate 3 | 125
Craniosynostosis 3 | 47
Liver carcinoma 3 | 217
Prostatic Neoplasms 3 | 471
Synostosis 3 | 18
cystic fibrosis 3 | 1,665
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
juvenile dermatomyositis 3 | 1,189
pancreatic cancer 3 | 2,300
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 2,087
Achondroplasia 2 | 20
Adenocarcinoma 2 | 115
Adenoma 2 | 165
Diaphragmatic Hernia 2 | 40
Endometrial cancer 2 | 25
Gaucher disease type 1 2 | 171
Heart disease 2 | 279
Irritable bowel syndrome 2 | 59
Kallmann Syndrome 2 | 33
Kidney cancer 2 | 118
Klinefelter's syndrome 2 | 59
LADD syndrome 2 | 9
Leukemia 2 | 88
Lung Neoplasms 2 | 171
Mammary Neoplasms 2 | 410
Mesothelioma 2 | 40
Myocardial Ischemia 2 | 169
Noonan Syndrome 2 | 33
Pick disease 2 | 1,893
Polycystic Ovary Syndrome 2 | 332
Polydactyly 2 | 93
Pulmonary Fibrosis 2 | 66
Rheumatoid Arthritis 2 | 1,160
Vascular disease 2 | 281
Weight Gain 2 | 87
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
colon cancer 2 | 1,475
dermatomyositis 2 | 933
fibroadenoma 2 | 557
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
primitive neuroectodermal tumor 2 | 3,031
progressive supranuclear palsy 2 | 674
tuberculosis 2 | 1,557
Burkitt Lymphoma 1 | 19
Calcinosis 1 | 62
Cardiomegaly 1 | 66
Colon Carcinoma 1 | 25
Diabetic Retinopathy 1 | 53
Diarrhea 1 | 155
Diffuse large B-cell lymphoma 1 | 41
Duane Retraction Syndrome 1 | 9
Fanconi syndrome 1 | 14
Fibrous dysplasia 1 | 15
Gastritis 1 | 44
Gastrointestinal system disease 1 | 50
Gestational Diabetes 1 | 17
Gliosis 1 | 16
Hemangioma 1 | 35
Hypotension 1 | 53
Lymphoid leukemia 1 | 69
McCune Albright syndrome 1 | 19
Neurofibromatosis 1 | 37
Opitz-GBBB syndrome 1 | 19
PARKINSON DISEASE, LATE-ONSET 1 | 18
Type 1 diabetes mellitus 1 | 101

Tissue

Digestive Tract 20 | 18,473
Endocrine System 20 | 18,512
Female tissues 20 | 18,647
Nervous System 20 | 18,561
Skin and soft tissues 20 | 18,115
Urinary Tract 20 | 18,444
Liver and Pancreas 19 | 18,136
Blood and immune system 18 | 17,995
Cardiovascular System 18 | 17,958
Male tissues 17 | 17,969
Respiratory system 16 | 17,484

Target Family

Non-IDG 15 | 11,971
Kinase 3 | 634
Enzyme 2 | 4,146

Reactome Pathway

PI-3K cascade:FGFR4 20 | 20
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.97848 10115.4 658
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.83412 76.6 133
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.45841 290.5 235
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.50869 46.0 252
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.30349 203.3 303
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.71907 54.5 120