Development Level

Tbio 52 | 11,178
Tchem 20 | 1,885
Tdark 8 | 6,569
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal epididymis morphology 2 | 42
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
persistence of hyaloid vascula... 2 | 33
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
microphthalmia 1 | 26
polydactyly 1 | 7
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 65 | 11,192
osteosarcoma 50 | 7,766
ovarian cancer 47 | 8,297
medulloblastoma, large-cell 39 | 6,086
ependymoma 36 | 4,559
glioblastoma 35 | 5,635
atypical teratoid / rhabdoid tumor 33 | 4,971
psoriasis 28 | 6,514
adult high grade glioma 26 | 3,701
Kidney cancer 24 | 2,548
lung cancer 24 | 4,607
oligodendroglioma 21 | 2,768
astrocytic glioma 20 | 2,530
Breast cancer 19 | 3,469
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,872
Astrocytoma, Pilocytic 16 | 3,006
group 3 medulloblastoma 16 | 4,002
subependymal giant cell astrocytoma 16 | 2,230
invasive ductal carcinoma 15 | 2,867
primitive neuroectodermal tumor 15 | 2,957
group 4 medulloblastoma 14 | 1,806
lung carcinoma 14 | 2,755
Cancer 13 | 2,388
interstitial cystitis 13 | 2,237
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,204
juvenile dermatomyositis 13 | 1,147
Centronuclear myopathy 12 | 27
Pick disease 12 | 1,856
pituitary cancer 12 | 1,915
ulcerative colitis 12 | 1,765
Autosomal recessive predisposition 11 | 1,407
diabetes mellitus 11 | 1,683
lung adenocarcinoma 11 | 2,627
pancreatic cancer 11 | 2,322
Schizophrenia 10 | 1,136
malignant mesothelioma 10 | 3,135
non-small cell lung cancer 10 | 2,799
Oculocerebrorenal syndrome 9 | 29
tuberculosis 9 | 1,963
Intellectual disability 8 | 998
Neurodegenerative disease 8 | 402
Acquired scoliosis 7 | 274
Curvature of spine 7 | 275
Neuropathy 7 | 254
Waldenstrons macroglobulinemia 7 | 742
astrocytoma 7 | 1,113
colon cancer 7 | 1,428
dermatomyositis 7 | 941
gastric carcinoma 7 | 781
primary Sjogren syndrome 7 | 710
Absent reflex 6 | 90
Absent tendon reflex 6 | 90
Cataract 6 | 290
Charcot-Marie-Tooth disease 6 | 59
Epilepsy 6 | 775
Frontal bossing 6 | 154
Liver cancer 6 | 589
Muscle hypotonia 6 | 562
Reflex, Deep Tendon, Absent 6 | 90
Seizures 6 | 584
acute myeloid leukemia 6 | 760
acute quadriplegic myopathy 6 | 1,133
aldosterone-producing adenoma 6 | 646
breast carcinoma 6 | 1,589
ductal carcinoma in situ 6 | 1,686
medulloblastoma 6 | 702
pancreatic carcinoma 6 | 555
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,911
spina bifida 6 | 1,053
Big calvaria 5 | 147
Bipolar Disorder 5 | 646
Cryptorchidism 5 | 287
DOID:2627 5 | 89
Dull intelligence 5 | 634
Endometrial cancer 5 | 301
Hypoplastic mandible condyle 5 | 273
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Lens Opacities 5 | 227
Low intelligence 5 | 634
Mandibular hypoplasia 5 | 273
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Micrognathism 5 | 273
Orbital separation excessive 5 | 240
Poor school performance 5 | 634
Progressive disorder 5 | 139
active Crohn's disease 5 | 882
cutaneous lupus erythematosus 5 | 1,016
primary pancreatic ductal adenocarcinoma 5 | 1,071
Alzheimer's disease 4 | 640
Depressed nasal bridge 4 | 191
Depressed nasal root/bridge 4 | 191
Multiple myeloma 4 | 1,296
Rheumatoid arthritis 4 | 1,156
adrenocortical carcinoma 4 | 1,385
cystic fibrosis 4 | 1,629
nasopharyngeal carcinoma 4 | 1,024

Tissue

Endocrine System 82 | 18,159
Female tissues 82 | 17,400
Blood and immune system 81 | 16,909
Digestive Tract 81 | 17,369
Male tissues 81 | 17,142
Nervous System 81 | 16,725
Liver and Pancreas 80 | 16,750
Respiratory system 80 | 16,393
Skin and soft tissues 80 | 17,230
Urinary Tract 80 | 16,678
Cardiovascular System 79 | 15,192

Target Family

Enzyme 40 | 4,145
Kinase 21 | 634
Non-IDG 21 | 12,091

Reactome Pathway

PI Metabolism 82 | 82
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Phosphatidylinositol 4-kinase beta PI4KB Tchem Kinase -1.85524 71.3 104
Phosphatidylinositide phosphatase SAC1 SACM1L Tbio Enzyme -2.04383 109.7 89
Pleckstrin homology domain-containing family A member 5 PLEKHA5 Tdark Non-IDG -0.62123 4.21 55
Phosphatidylinositide phosphatase SAC2 INPP5F Tbio Enzyme -0.71120 5.56 89
Pleckstrin homology domain-containing family A member 6 PLEKHA6 Tdark Non-IDG -0.18435 1.27 103
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta PIK3C2B Tchem Kinase -1.50611 34.7 157
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Myotubularin-related protein 1 MTMR1 Tbio Enzyme -0.89579 6.93 82
Myotubularin-related protein 13 SBF2 Tbio Non-IDG -1.38747 24.7 15