Development Level

Tbio 23 | 10,625
Tchem 7 | 1,890
Tclin 6 | 602
Tdark 4 | 7,003

Disease

Rheumatoid Arthritis 20 | 1,170
Narcolepsy 17 | 69
sarcoidosis 17 | 368
lung carcinoma 16 | 2,844
systemic lupus erythematosus 16 | 172
Berylliosis 15 | 28
Multiple Sclerosis, Susceptibility to 15 | 15
Narcolepsy-cataplexy 14 | 21
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
follicular lymphoma 13 | 17
limited scleroderma 13 | 19
diabetes mellitus 12 | 1,663
lung cancer 12 | 4,473
interstitial cystitis 10 | 2,299
psoriasis 10 | 6,685
Hypersensitivity reaction type II disease 9 | 235
Multiple Sclerosis 9 | 498
breast carcinoma 9 | 1,614
osteosarcoma 9 | 7,933
Cancer 8 | 2,346
cutaneous lupus erythematosus 8 | 1,056
ovarian cancer 8 | 8,491
primary Sjogren syndrome 8 | 788
glioblastoma 7 | 5,572
invasive ductal carcinoma 7 | 2,950
non-small cell lung cancer 7 | 2,798
tuberculosis 7 | 1,563
Celiac disease 6 | 112
Hypersensitivity 6 | 63
Juvenile rheumatoid arthritis 6 | 105
Type 1 diabetes mellitus 6 | 104
dermatomyositis 6 | 966
Asthma 5 | 349
Lupus Erythematosus, Systemic 5 | 73
Systemic scleroderma 5 | 66
active Crohn's disease 5 | 918
adult high grade glioma 5 | 2,148
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 2,087
Addison's disease 4 | 29
Autoimmune thyroiditis 4 | 24
Diabetes Mellitus, Insulin-Dependent 4 | 77
Duchenne muscular dystrophy 4 | 602
Graves' disease 4 | 25
Hepatitis B, Chronic 4 | 15
astrocytoma 4 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
medulloblastoma, large-cell 4 | 6,234
Angioedema 3 | 36
Atopic dermatitis 3 | 944
Down syndrome 3 | 548
Hepatitis B 3 | 103
IGA Glomerulonephritis 3 | 454
Leprosy 3 | 77
Liver disease 3 | 219
Polymyalgia rheumatica 3 | 10
Pre B-cell acute lymphoblastic leukemia 3 | 4
Psoriatic arthritis 3 | 85
Renal transplant rejection 3 | 13
Severe Combined Immunodeficiency 3 | 46
Urticaria 3 | 53
Vasculitis 3 | 64
Waldenstrons macroglobulinemia 3 | 764
active ulcerative colitis 3 | 477
chronic lymphocytic leukemia 3 | 244
cystic fibrosis 3 | 1,670
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,875
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
juvenile dermatomyositis 3 | 1,189
limb girdle muscular dystrophy 2I 3 | 56
lung adenocarcinoma 3 | 2,714
malignant mesothelioma 3 | 3,163
membranous glomerulonephritis 3 | 12
pilocytic astrocytoma 3 | 3,086
Becker muscular dystrophy 2 | 187
Breast cancer 2 | 3,098
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Collagen disease 2 | 25
Drug Eruptions 2 | 18
Drug-Induced Liver Injury 2 | 118
Myasthenia Gravis 2 | 26
Oropharynx cancer 2 | 9
Pancreatitis 2 | 97
Pick disease 2 | 1,893
Proteinuria 2 | 63
adrenocortical carcinoma 2 | 1,427
nephrosclerosis 2 | 329
non diabetic and post-ischemic heart failure 2 | 200
oligodendroglioma 2 | 2,849
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
posterior fossa group A ependymoma 2 | 1,511
primary pancreatic ductal adenocarcinoma 2 | 1,271
type I diabetes mellitus 2 | 22

Tissue

Blood and immune system 25 | 17,994
Digestive Tract 25 | 18,472
Endocrine System 25 | 18,511
Female tissues 25 | 18,646
Liver and Pancreas 25 | 18,135
Male tissues 25 | 17,968
Nervous System 25 | 18,560
Respiratory system 25 | 17,483
Urinary Tract 25 | 18,443
Cardiovascular System 24 | 17,957
Skin and soft tissues 20 | 18,114

Target Family

Non-IDG 36 | 11,969
Enzyme 2 | 4,146
Kinase 2 | 634

Reactome Pathway

PD-1 signaling 40 | 40
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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