Development Level

Tbio 23 | 11,651
Tchem 6 | 1,388
Tclin 6 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Rheumatoid arthritis 20 | 1,191
Narcolepsy 17 | 72
sarcoidosis 17 | 370
Berylliosis 15 | 28
Multiple Sclerosis, Susceptibility to 15 | 15
Systemic lupus erythematosus 15 | 194
lung carcinoma 15 | 2,843
Narcolepsy-cataplexy 14 | 21
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
diabetes mellitus 13 | 1,728
follicular lymphoma 13 | 20
limited scleroderma 13 | 19
lung cancer 11 | 4,740
psoriasis 11 | 6,694
Hypersensitivity reaction type II disease 10 | 253
Multiple Sclerosis 10 | 540
breast carcinoma 9 | 1,638
interstitial cystitis 9 | 2,312
Cancer 8 | 2,499
osteosarcoma 8 | 7,950
ovarian cancer 8 | 8,520
tuberculosis 8 | 2,010
Juvenile rheumatoid arthritis 7 | 111
cutaneous lupus erythematosus 7 | 1,057
glioblastoma 7 | 5,792
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
primary Sjogren syndrome 7 | 735
Carcinoma 6 | 11,493
Celiac disease 6 | 116
Hepatitis B 6 | 108
Hypersensitivity 6 | 63
Type 1 diabetes mellitus 6 | 109
Autoimmune Diseases 5 | 67
Autosomal recessive predisposition 5 | 1,442
Recurrent respiratory infections 5 | 141
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
adult high grade glioma 5 | 3,801
subependymal giant cell astrocytoma 5 | 2,287
Addison's disease 4 | 31
Arthritis, Rheumatoid 4 | 174
Asthma 4 | 385
Autoimmune thyroiditis 4 | 27
Duchenne muscular dystrophy 4 | 601
Graves' disease 4 | 24
Immunologic Deficiency Syndromes 4 | 113
Infantile onset 4 | 238
Lupus Erythematosus, Systemic 4 | 67
Vasculitis 4 | 80
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
medulloblastoma, large-cell 4 | 6,241
ulcerative colitis 4 | 1,819
Angioedema 3 | 38
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Breast cancer 3 | 3,578
Collagen disease 3 | 27
Crohn's disease 3 | 321
Diabetes Mellitus, Insulin-Dependent 3 | 48
Diabetes Mellitus, Type 1 3 | 43
Down syndrome 3 | 499
Eczema 3 | 45
Failure to gain weight 3 | 365
Leprosy 3 | 73
Liver disease 3 | 237
Lymphopenia 3 | 67
Membranous glomerulonephritis 3 | 13
Myositis 3 | 30
Oropharyngeal Neoplasms 3 | 4
Pediatric failure to thrive 3 | 365
Pemphigus 3 | 23
Polymyalgia rheumatica 3 | 10
Pre B-cell acute lymphoblastic leukemia 3 | 5
Proteinuria 3 | 144
Psoriatic arthritis 3 | 86
Recurrent infections 3 | 48
Renal transplant rejection 3 | 13
Severe combined immunodeficiency 3 | 51
Urticaria 3 | 67
Waldenstrons macroglobulinemia 3 | 765
Weight decreased 3 | 103
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
ependymoma 3 | 4,679
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Excessive daytime somnolence 2 | 14
Variable expressivity 2 | 157

Tissue

Blood and immune system 19 | 16,909
Liver and Pancreas 19 | 16,750
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Male tissues 18 | 17,142
Urinary Tract 18 | 16,678
Cardiovascular System 17 | 15,192
Nervous System 17 | 16,725

Target Family

Non-IDG 35 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634

Reactome Pathway

PD-1 signaling 39 | 39
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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