Development Level

Tbio 78 | 11,445
Tchem 6 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal heart morphology 4 | 162
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
corneal opacity 2 | 32
decreased circulating choleste... 2 | 93
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye size 1 | 7
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal heart shape 1 | 5
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placement of pupils 1 | 6
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
absent pinna reflex 1 | 23
curly tail 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
embryonic growth retardation 1 | 106
enlarged cecum 1 | 5
enlarged seminal vesicle 1 | 10
fused cornea and lens 1 | 5
hydrops fetalis 1 | 1
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating insulin ... 1 | 3
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
kinked tail 1 | 2
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small heart 1 | 10
trunk curl 1 | 16

Disease

ovarian cancer 66 | 8,520
Carcinoma 46 | 11,493
psoriasis 42 | 6,694
lung cancer 37 | 4,740
osteosarcoma 36 | 7,950
glioblastoma 34 | 5,792
Multiple myeloma 33 | 1,332
Breast cancer 25 | 3,578
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 24 | 4,679
Cancer 21 | 2,499
group 3 medulloblastoma 21 | 4,104
medulloblastoma, large-cell 21 | 6,241
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 15 | 3,081
HIV Infections 15 | 102
Waldenstrons macroglobulinemia 15 | 765
adult high grade glioma 15 | 3,801
lung carcinoma 14 | 2,843
malignant mesothelioma 14 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
invasive ductal carcinoma 13 | 2,951
tuberculosis 13 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung adenocarcinoma 12 | 2,716
oligodendroglioma 12 | 2,850
astrocytic glioma 11 | 2,597
astrocytoma 11 | 1,146
dermatomyositis 11 | 966
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primitive neuroectodermal tumor 11 | 3,035
subependymal giant cell astrocytoma 11 | 2,287
Kidney cancer 9 | 2,613
Liver Cirrhosis, Experimental 9 | 769
cystic fibrosis 9 | 1,696
non primary Sjogren syndrome sicca 9 | 891
pancreatic cancer 9 | 2,398
Pick disease 8 | 1,894
Rheumatoid arthritis 8 | 1,191
Robinow syndrome 8 | 11
primary pancreatic ductal adenocarcinoma 8 | 1,109
spina bifida 8 | 1,074
acute myeloid leukemia 7 | 783
acute quadriplegic myopathy 7 | 1,158
cutaneous lupus erythematosus 7 | 1,057
diabetes mellitus 7 | 1,728
pituitary cancer 7 | 1,972
Osteoporosis 6 | 363
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Autosomal recessive predisposition 5 | 1,442
Intellectual disability 5 | 1,016
Mantle cell lymphoma 5 | 23
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
ulcerative colitis 5 | 1,819
Cleft Palate 4 | 271
Cognitive delay 4 | 608
Congenital hypoplasia of penis 4 | 176
Crohn's disease 4 | 321
Cryptorchidism 4 | 296
Depressive disorder 4 | 409
Frontal bossing 4 | 157
Gingival Hyperplasia 4 | 34
Gingival Hypertrophy 4 | 34
Gingival Overgrowth 4 | 36
Global developmental delay 4 | 608
Hypoplastic mandible condyle 4 | 275
Hypotrophic malar bone 4 | 129
Long philtrum 4 | 137
Macroglossia 4 | 65
Malar flattening 4 | 129
Mandibular hypoplasia 4 | 275
Mental and motor retardation 4 | 608
Micrognathism 4 | 275
Orbital separation excessive 4 | 244
chronic kidney disease 4 | 90
fibroadenoma 4 | 559
progressive supranuclear palsy 4 | 676
sonic hedgehog group medulloblastoma 4 | 467
Alzheimer's disease 3 | 658
Anteverted nostril 3 | 191
Bipolar Disorder 3 | 666
Broad flat nasal bridge 3 | 236
Delayed bone age 3 | 136
Nasal bridge wide 3 | 236
Pectus excavatum 3 | 100
Posteriorly rotated ear 3 | 61
Short nose 3 | 132
Small nose 3 | 132
Umbilical hernia 3 | 93
Vascular disease 3 | 319
adrenocortical carcinoma 3 | 1,428
hepatocellular carcinoma 3 | 547

Tissue

Endocrine System 91 | 18,159
Blood and immune system 90 | 16,909
Digestive Tract 90 | 17,369
Female tissues 90 | 17,400
Nervous System 90 | 16,725
Liver and Pancreas 89 | 16,750
Male tissues 89 | 17,142
Respiratory system 89 | 16,393
Urinary Tract 89 | 16,678
Skin and soft tissues 88 | 17,230
Cardiovascular System 86 | 15,192

Target Family

Enzyme 45 | 4,145
Non-IDG 33 | 12,091
GPCR 8 | 408
Kinase 6 | 634

Reactome Pathway

PCP/CE pathway 92 | 92
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Disheveled-associated activator of morphogenesis 1 DAAM1 Tbio Non-IDG -1.45166 30.8 269
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181