Development Level

Tbio 47 | 11,445
Tchem 30 | 1,598
Tdark 10 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased total body fat amoun... 2 | 207
edema 2 | 59
increased grip strength 2 | 41
microphthalmia 2 | 26
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 53 | 8,520
Carcinoma 52 | 11,493
glioblastoma 42 | 5,792
Cancer 39 | 2,499
osteosarcoma 39 | 7,950
psoriasis 38 | 6,694
lung cancer 36 | 4,740
atypical teratoid / rhabdoid tumor 35 | 5,112
Breast cancer 34 | 3,578
medulloblastoma, large-cell 32 | 6,241
group 3 medulloblastoma 28 | 4,104
malignant mesothelioma 23 | 3,232
ependymoma 22 | 4,679
primitive neuroectodermal tumor 21 | 3,035
invasive ductal carcinoma 20 | 2,951
oligodendroglioma 20 | 2,850
pancreatic cancer 20 | 2,398
adult high grade glioma 19 | 3,801
breast carcinoma 18 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung adenocarcinoma 17 | 2,716
astrocytic glioma 16 | 2,597
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
non-small cell lung cancer 16 | 2,890
Astrocytoma, Pilocytic 15 | 3,081
Pick disease 14 | 1,894
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
diabetes mellitus 13 | 1,728
Vascular disease 12 | 319
colon cancer 12 | 1,478
subependymal giant cell astrocytoma 12 | 2,287
Melanoma 11 | 711
Schizophrenia 11 | 1,160
group 4 medulloblastoma 11 | 1,855
pituitary cancer 11 | 1,972
Kidney cancer 10 | 2,613
acute myeloid leukemia 10 | 783
cystic fibrosis 10 | 1,696
Lung Neoplasms 9 | 232
Multiple myeloma 9 | 1,332
Rheumatoid arthritis 9 | 1,191
astrocytoma 9 | 1,146
tuberculosis 9 | 2,010
Alzheimer's disease 8 | 658
Stomach Neoplasms 8 | 300
lung carcinoma 8 | 2,843
nasopharyngeal carcinoma 8 | 1,058
primary pancreatic ductal adenocarcinoma 8 | 1,109
ulcerative colitis 8 | 1,819
Amyotrophic lateral sclerosis 7 | 451
Arthritis 7 | 290
Intellectual disability 7 | 1,016
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
cutaneous lupus erythematosus 7 | 1,057
juvenile dermatomyositis 7 | 1,187
non-small cell lung carcinoma 7 | 317
progressive supranuclear palsy 7 | 676
Carcinoma, Hepatocellular 6 | 228
Cholestasis, Extrahepatic 6 | 25
Disease Models, Animal 6 | 155
Kidney disease 6 | 430
Liver carcinoma 6 | 240
Neurodegenerative disease 6 | 414
Toxic encephalopathy 6 | 141
Waldenstrons macroglobulinemia 6 | 765
dermatomyositis 6 | 966
gastric cancer 6 | 459
hepatocellular carcinoma 6 | 547
pancreatic carcinoma 6 | 562
Arthritis, Juvenile 5 | 126
Atopic dermatitis 5 | 952
Brain Ischemia 5 | 110
Cardiomyopathies 5 | 110
Chronic Lymphocytic Leukemia 5 | 262
Dull intelligence 5 | 645
Endometriosis 5 | 540
Epilepsy 5 | 792
Eye disease 5 | 62
Glioma 5 | 74
Hyperalgesia 5 | 83
Juvenile arthritis 5 | 126
Liver cancer 5 | 604
Low intelligence 5 | 645
Lung disease 5 | 142
Lymphoma 5 | 81
Melanocytic nevus 5 | 43
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Mesothelioma, Malignant 5 | 105
Parkinson's disease 5 | 392
Poor school performance 5 | 645
Precancerous Conditions 5 | 80
Seizures 5 | 596
medulloblastoma 5 | 720
spina bifida 5 | 1,074
tuberculosis and treatment for 6 months 5 | 409

Tissue

Blood and immune system 87 | 16,909
Endocrine System 87 | 18,159
Digestive Tract 86 | 17,369
Female tissues 86 | 17,400
Skin and soft tissues 86 | 17,230
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Urinary Tract 85 | 16,678
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 46 | 12,091
Kinase 20 | 634
Enzyme 8 | 4,145
Transcription Factor 8 | 1,400
Epigenetic 7 | 242

Reactome Pathway

Oxidative Stress Induced Senes... 89 | 89
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.27537 183.4 505
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.22888 174.2 272
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.37369 24.3 223
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427