Development Level

Tbio 44 | 10,625
Tchem 31 | 1,890
Tdark 13 | 7,003
Tclin 2 | 602

IMPC Term

abnormal bone structure 3 | 131
decreased lean body mass 3 | 195
preweaning lethality, complete... 3 | 633
abnormal lens morphology 2 | 73
cataract 2 | 26
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased total body fat amoun... 2 | 186
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal joint morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
decreased CD4-positive, CD25-p... 1 | 24
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased rib number 1 | 59
female infertility 1 | 34
hydrops fetalis 1 | 22
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased sacral vertebrae num... 1 | 62
male infertility 1 | 62
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82

Disease

ovarian cancer 52 | 8,484
glioblastoma 40 | 5,572
Cancer 39 | 2,346
osteosarcoma 39 | 7,933
psoriasis 38 | 6,685
lung cancer 37 | 4,466
atypical teratoid / rhabdoid tumor 33 | 4,369
medulloblastoma, large-cell 32 | 6,234
Breast cancer 29 | 3,094
primitive neuroectodermal tumor 21 | 3,031
invasive ductal carcinoma 20 | 2,950
malignant mesothelioma 20 | 3,162
oligodendroglioma 20 | 2,849
pancreatic cancer 19 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
ependymoma 17 | 2,514
group 3 medulloblastoma 17 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung adenocarcinoma 17 | 2,713
breast carcinoma 16 | 1,614
ductal carcinoma in situ 16 | 1,745
pilocytic astrocytoma 16 | 3,086
Pick disease 15 | 1,893
non-small cell lung cancer 15 | 2,798
Mammary Neoplasms 13 | 410
astrocytic glioma 13 | 2,241
diabetes mellitus 13 | 1,663
Vascular disease 12 | 281
colon cancer 12 | 1,475
medulloblastoma 12 | 1,524
subependymal giant cell astrocytoma 12 | 2,287
adult high grade glioma 11 | 2,148
astrocytoma 11 | 1,493
pediatric high grade glioma 11 | 2,712
pituitary cancer 11 | 1,972
acute myeloid leukemia 10 | 780
cystic fibrosis 10 | 1,665
group 4 medulloblastoma 10 | 1,875
ulcerative colitis 10 | 2,087
Multiple myeloma 9 | 1,327
Rheumatoid Arthritis 9 | 1,160
Alzheimer's disease 8 | 644
Lung Neoplasms 8 | 171
Melanoma 8 | 261
Stomach Neoplasms 8 | 282
lung carcinoma 8 | 2,844
nasopharyngeal carcinoma 8 | 1,056
non-small cell lung carcinoma 8 | 413
primary pancreatic ductal adenocarcinoma 8 | 1,271
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis and treatment for 6 months 8 | 686
Amyotrophic Lateral Sclerosis 7 | 431
Arthritis 7 | 248
Carcinoma 7 | 2,147
Toxic encephalopathy 7 | 131
acute quadriplegic myopathy 7 | 1,157
adrenocortical carcinoma 7 | 1,427
cutaneous lupus erythematosus 7 | 1,056
juvenile dermatomyositis 7 | 1,189
pancreatic carcinoma 7 | 567
progressive supranuclear palsy 7 | 674
Kidney disease 6 | 396
Waldenstrons macroglobulinemia 6 | 765
dermatomyositis 6 | 933
gastric cancer 6 | 430
inflammatory breast cancer 6 | 404
posterior fossa group A ependymoma 6 | 1,511
Atopic dermatitis 5 | 944
Brain Ischemia 5 | 87
Cardiomyopathies 5 | 90
Chronic Lymphocytic Leukemia 5 | 242
Endometriosis 5 | 535
Eye disease 5 | 55
Glioma 5 | 65
Juvenile arthritis 5 | 124
Liver carcinoma 5 | 217
Lung disease 5 | 132
hepatocellular carcinoma 5 | 532
spina bifida 5 | 1,064
tuberculosis 5 | 1,557
Adenoma 4 | 165
Blastic phase chronic myeloid leukemia 4 | 58
Brain disease 4 | 83
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Li-Fraumeni Syndrome 4 | 13
Liver neoplasms 4 | 109
Lymphoid leukemia 4 | 69
Neoplasm Invasiveness 4 | 127
Neoplasm Metastasis 4 | 138
Neoplastic Cell Transformation 4 | 81
Neurodegenerative disease 4 | 383
Obesity 4 | 616
Parkinson's disease 4 | 364
Precancerous Conditions 4 | 69
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
Reperfusion Injury 4 | 84
interstitial cystitis 4 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795

Tissue

Endocrine System 89 | 18,512
Blood and immune system 88 | 17,995
Digestive Tract 88 | 18,473
Female tissues 88 | 18,647
Male tissues 88 | 17,969
Nervous System 88 | 18,561
Urinary Tract 88 | 18,444
Cardiovascular System 87 | 17,958
Liver and Pancreas 87 | 18,136
Respiratory system 87 | 17,484
Skin and soft tissues 81 | 18,115

Target Family

Non-IDG 47 | 11,971
Kinase 20 | 634
Enzyme 8 | 4,146
Transcription Factor 8 | 1,400
Epigenetic 7 | 242

Reactome Pathway

Oxidative Stress Induced Senes... 90 | 90
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Polyhomeotic-like protein 3 PHC3 Tbio Non-IDG -2.68637 475.4 59
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.06838 144.7 243
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Polycomb complex protein BMI-1 BMI1 Tbio Non-IDG -2.80895 691.3 553
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.65911 362.2 617