Development Level

Tbio 44 | 10,625
Tchem 31 | 1,890
Tdark 13 | 7,003
Tclin 2 | 602

IMPC Phenotype

abnormal bone structure 3 | 131
decreased lean body mass 3 | 195
preweaning lethality, complete... 3 | 633
abnormal lens morphology 2 | 73
cataract 2 | 26
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased total body fat amoun... 2 | 186
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal joint morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
decreased CD4-positive, CD25-p... 1 | 24
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased rib number 1 | 59
female infertility 1 | 34
hydrops fetalis 1 | 22
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased sacral vertebrae num... 1 | 62
male infertility 1 | 62
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82

Disease

ovarian cancer 52 | 8,491
glioblastoma 40 | 5,572
Cancer 39 | 2,346
osteosarcoma 39 | 7,933
psoriasis 38 | 6,685
lung cancer 37 | 4,473
atypical teratoid / rhabdoid tumor 33 | 4,369
medulloblastoma, large-cell 32 | 6,234
Breast cancer 29 | 3,098
primitive neuroectodermal tumor 21 | 3,031
invasive ductal carcinoma 20 | 2,950
malignant mesothelioma 20 | 3,163
oligodendroglioma 20 | 2,849
pancreatic cancer 19 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
ependymoma 17 | 2,514
group 3 medulloblastoma 17 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung adenocarcinoma 17 | 2,714
breast carcinoma 16 | 1,614
ductal carcinoma in situ 16 | 1,745
pilocytic astrocytoma 16 | 3,086
Pick disease 15 | 1,893
non-small cell lung cancer 15 | 2,798
Mammary Neoplasms 13 | 410
astrocytic glioma 13 | 2,241
diabetes mellitus 13 | 1,663
Vascular disease 12 | 281
colon cancer 12 | 1,475
medulloblastoma 12 | 1,524
subependymal giant cell astrocytoma 12 | 2,287
adult high grade glioma 11 | 2,148
astrocytoma 11 | 1,493
pediatric high grade glioma 11 | 2,712
pituitary cancer 11 | 1,972
acute myeloid leukemia 10 | 785
cystic fibrosis 10 | 1,670
group 4 medulloblastoma 10 | 1,875
ulcerative colitis 10 | 2,087
Multiple myeloma 9 | 1,327
Rheumatoid Arthritis 9 | 1,170
Alzheimer's disease 8 | 644
Lung Neoplasms 8 | 171
Melanoma 8 | 261
Stomach Neoplasms 8 | 282
lung carcinoma 8 | 2,844
nasopharyngeal carcinoma 8 | 1,056
non-small cell lung carcinoma 8 | 413
primary pancreatic ductal adenocarcinoma 8 | 1,271
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis and treatment for 6 months 8 | 686
Amyotrophic Lateral Sclerosis 7 | 432
Arthritis 7 | 248
Carcinoma 7 | 2,147
Toxic encephalopathy 7 | 131
acute quadriplegic myopathy 7 | 1,157
adrenocortical carcinoma 7 | 1,427
cutaneous lupus erythematosus 7 | 1,056
juvenile dermatomyositis 7 | 1,189
pancreatic carcinoma 7 | 567
progressive supranuclear palsy 7 | 674
Kidney disease 6 | 397
Waldenstrons macroglobulinemia 6 | 764
dermatomyositis 6 | 966
gastric cancer 6 | 436
hepatocellular carcinoma 6 | 550
inflammatory breast cancer 6 | 404
posterior fossa group A ependymoma 6 | 1,511
Atopic dermatitis 5 | 944
Brain Ischemia 5 | 87
Cardiomyopathies 5 | 90
Endometriosis 5 | 535
Eye disease 5 | 55
Glioma 5 | 66
Juvenile arthritis 5 | 124
Liver carcinoma 5 | 217
Lung disease 5 | 136
chronic lymphocytic leukemia 5 | 244
spina bifida 5 | 1,064
tuberculosis 5 | 1,563
Adenoma 4 | 165
Brain disease 4 | 84
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Li-Fraumeni syndrome 4 | 13
Liver neoplasms 4 | 108
Lymphoid leukemia 4 | 69
Neoplasm Invasiveness 4 | 127
Neoplasm Metastasis 4 | 138
Neoplastic Cell Transformation 4 | 81
Neurodegenerative disease 4 | 383
Obesity 4 | 616
Parkinson's disease 4 | 364
Precancerous Conditions 4 | 69
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
Reperfusion Injury 4 | 84
Stomach cancer 4 | 18
interstitial cystitis 4 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795

Tissue

Endocrine System 89 | 18,511
Blood and immune system 88 | 17,994
Digestive Tract 88 | 18,472
Female tissues 88 | 18,646
Male tissues 88 | 17,968
Nervous System 88 | 18,560
Urinary Tract 88 | 18,443
Cardiovascular System 87 | 17,957
Liver and Pancreas 87 | 18,135
Respiratory system 87 | 17,483
Skin and soft tissues 81 | 18,114

Target Family

Non-IDG 47 | 11,969
Kinase 20 | 634
Enzyme 8 | 4,146
Transcription Factor 8 | 1,400
Epigenetic 7 | 242

Reactome Pathway

Oxidative Stress Induced Senes... 90 | 90
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.67376 362.2 617
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339