Development Level

Tbio 201 | 10,625
Tdark 93 | 7,003
Tchem 30 | 1,890
Tclin 10 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 33 | 633
embryonic lethality prior to t... 12 | 187
preweaning lethality, incomple... 9 | 260
embryonic lethality prior to o... 8 | 148
abnormal behavior 6 | 226
decreased total body fat amoun... 6 | 186
abnormal embryo size 5 | 112
decreased body weight 5 | 174
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased lean body mass 5 | 195
decreased caudal vertebrae num... 4 | 49
increased circulating alkaline... 4 | 119
abnormal bone structure 3 | 131
abnormal embryo turning 3 | 15
abnormal head morphology 3 | 10
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
decreased fasted circulating g... 3 | 49
decreased lumbar vertebrae num... 3 | 62
embryonic growth retardation 3 | 28
impaired glucose tolerance 3 | 52
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased sacral vertebrae num... 3 | 62
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
abnormal cranium morphology 2 | 32
abnormal gait 2 | 51
abnormal hindbrain development 2 | 24
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal retinal blood vessel ... 2 | 18
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating amylase ... 2 | 24
decreased circulating calcium ... 2 | 33
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
enlarged heart 2 | 111
enlarged spleen 2 | 26
hyperactivity 2 | 108
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating free fat... 2 | 17
increased circulating glycerol... 2 | 11
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased prepulse inhibition 2 | 21
increased total body fat amoun... 2 | 57
abnormal behavioral response t... 1 | 52
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased red blood cell distr... 1 | 11
decreased vertical activity 1 | 22
hydrometra 1 | 13
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased mean platelet volume 1 | 19
increased rib number 1 | 41
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 213 | 8,484
osteosarcoma 162 | 7,933
medulloblastoma, large-cell 114 | 6,234
psoriasis 103 | 6,685
glioblastoma 100 | 5,572
lung cancer 94 | 4,466
atypical teratoid / rhabdoid tumor 79 | 4,369
posterior fossa group B ependymoma 66 | 1,530
group 3 medulloblastoma 57 | 2,254
primitive neuroectodermal tumor 56 | 3,031
Breast cancer 55 | 3,094
malignant mesothelioma 55 | 3,162
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,795
pediatric high grade glioma 53 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
Multiple myeloma 49 | 1,327
Pick disease 48 | 1,893
astrocytic glioma 48 | 2,241
ependymoma 48 | 2,514
oligodendroglioma 47 | 2,849
Carcinoma 42 | 2,147
non-small cell lung cancer 42 | 2,798
Polydactyly 41 | 93
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
invasive ductal carcinoma 38 | 2,950
Ciliopathy 37 | 57
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,956
pilocytic astrocytoma 36 | 3,086
Intellectual disability 35 | 573
Obesity 35 | 616
non primary Sjogren syndrome sicca 34 | 840
adult high grade glioma 33 | 2,148
Nephronophthisis 32 | 74
colon cancer 29 | 1,475
Cancer 28 | 2,346
Bardet-Biedl Syndrome 27 | 40
lung adenocarcinoma 27 | 2,713
medulloblastoma 27 | 1,524
sonic hedgehog group medulloblastoma 27 | 1,482
Joubert syndrome 26 | 61
Retinitis pigmentosa 26 | 153
diabetes mellitus 26 | 1,663
atypical teratoid/rhabdoid tumor 25 | 1,095
breast carcinoma 25 | 1,614
subependymal giant cell astrocytoma 25 | 2,287
group 4 medulloblastoma 24 | 1,875
nasopharyngeal carcinoma 24 | 1,056
acute myeloid leukemia 23 | 780
chronic rhinosinusitis 22 | 512
dermatomyositis 22 | 933
Waldenstrons macroglobulinemia 21 | 765
astrocytoma 20 | 1,493
Asphyxiating thoracic dystrophy 19 | 32
acute quadriplegic myopathy 19 | 1,157
progressive supranuclear palsy 19 | 674
tuberculosis 19 | 1,557
Fundus dystrophy 18 | 77
Meckel syndrome 18 | 48
pancreatic cancer 18 | 2,300
Rheumatoid Arthritis 17 | 1,160
Senior-Loken syndrome 17 | 21
juvenile dermatomyositis 17 | 1,189
pituitary cancer 17 | 1,972
tuberculosis and treatment for 6 months 17 | 686
ulcerative colitis 17 | 2,087
lung carcinoma 16 | 2,844
Mammary Neoplasms 15 | 410
adrenocortical carcinoma 15 | 1,427
ductal carcinoma in situ 15 | 1,745
Microcephaly 14 | 149
Cystic kidney disease 13 | 25
Cone dystrophy 12 | 57
hepatocellular carcinoma 12 | 532
interstitial cystitis 12 | 2,299
posterior fossa group A ependymoma 12 | 1,511
gastric cancer 11 | 430
Alzheimer's disease 10 | 644
Endometriosis 10 | 535
Orofaciodigital syndrome 10 | 19
Sensenbrenner syndrome 10 | 15
primary pancreatic ductal adenocarcinoma 10 | 1,271
Ellis-Van Creveld syndrome 9 | 18
Meckel-Gruber syndrome 9 | 15
Parkinson's disease 9 | 364
Polycystic kidney disease 9 | 54
Renal dysplasia and retinal aplasia (disorder) 9 | 10
active Crohn's disease 9 | 918
cystic fibrosis and chronic rhinosinusitis 9 | 213
Amyotrophic Lateral Sclerosis 8 | 431
Down syndrome 8 | 548
Jeune thoracic dystrophy 8 | 9
Leber congenital amaurosis 8 | 72
Schizophrenia 8 | 501
Situs Inversus 8 | 48
active ulcerative colitis 8 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
Hydrolethalus syndrome 7 | 128
Prostatic Neoplasms 7 | 471
aldosterone-producing adenoma 7 | 664
cystic fibrosis 7 | 1,665

Tissue

Blood and immune system 332 | 17,995
Nervous System 332 | 18,561
Cardiovascular System 331 | 17,958
Digestive Tract 331 | 18,473
Endocrine System 331 | 18,512
Female tissues 331 | 18,647
Liver and Pancreas 331 | 18,136
Urinary Tract 331 | 18,444
Male tissues 330 | 17,969
Respiratory system 330 | 17,484
Skin and soft tissues 328 | 18,115

Target Family

Non-IDG 259 | 11,971
Enzyme 32 | 4,146
Kinase 15 | 634
Epigenetic 8 | 242
Transcription Factor 8 | 1,400
GPCR 4 | 406
Ion Channel 4 | 341
Nuclear Receptor 4 | 48

Reactome Pathway

Organelle biogenesis and maint... 334 | 334
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
39S ribosomal protein L19, mitochondrial MRPL19 Tbio Non-IDG -0.91149 8.14 108
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -1.97186 101.3 125
Peroxisome proliferator-activated receptor gamma coactivator 1-beta PPARGC1B Tbio Non-IDG -2.61803 420.9 51