Development Level

Tbio 202 | 11,651
Tdark 25 | 6,593
Tchem 23 | 1,388
Tclin 11 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to t... 11 | 278
abnormal embryo size 9 | 220
abnormal behavior 8 | 298
decreased total body fat amoun... 7 | 207
embryonic growth retardation 6 | 106
male infertility 6 | 123
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
embryonic lethality prior to o... 5 | 239
abnormal embryo turning 4 | 31
decreased body weight 4 | 161
decreased caudal vertebrae num... 4 | 53
decreased circulating serum al... 4 | 82
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
decreased vertical activity 4 | 208
enlarged heart 4 | 210
increased bone mineral content 4 | 108
increased circulating alkaline... 4 | 122
increased lean body mass 4 | 172
prenatal lethality prior to he... 4 | 87
abnormal cranium morphology 3 | 36
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal head morphology 3 | 10
abnormal heart morphology 3 | 162
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
decreased circulating total pr... 3 | 49
hydrometra 3 | 53
hyperactivity 3 | 148
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
small superior vagus ganglion 3 | 74
abnormal bone structure 2 | 187
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
cataract 2 | 92
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
edema 2 | 59
enlarged spleen 2 | 41
enlarged uterus 2 | 11
increased bone mineral density 2 | 72
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased grip strength 2 | 41
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
long tibia 2 | 25
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal heart left ventricle ... 1 | 16
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
increased body weight 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 188 | 11,493
ovarian cancer 158 | 8,520
osteosarcoma 140 | 7,950
medulloblastoma, large-cell 105 | 6,241
ependymoma 98 | 4,679
glioblastoma 95 | 5,792
atypical teratoid / rhabdoid tumor 94 | 5,112
psoriasis 91 | 6,694
group 3 medulloblastoma 81 | 4,104
lung cancer 80 | 4,740
adult high grade glioma 64 | 3,801
primitive neuroectodermal tumor 59 | 3,035
Intellectual disability 54 | 1,016
Kidney cancer 54 | 2,613
malignant mesothelioma 53 | 3,232
Breast cancer 51 | 3,578
oligodendroglioma 50 | 2,850
Pick disease 47 | 1,894
astrocytic glioma 47 | 2,597
Polydactyly 46 | 107
Obesity 44 | 678
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
Astrocytoma, Pilocytic 39 | 3,081
Ciliopathy 39 | 71
Autosomal recessive predisposition 38 | 1,442
Multiple myeloma 37 | 1,332
invasive ductal carcinoma 36 | 2,951
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Nephronophthisis 35 | 80
Poor school performance 35 | 645
Cancer 34 | 2,499
non-small cell lung cancer 34 | 2,890
Bardet-Biedl syndrome 33 | 51
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
Short stature 32 | 531
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
diabetes mellitus 31 | 1,728
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Mental and motor retardation 30 | 608
Retinitis Pigmentosa 30 | 226
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
Joubert syndrome 29 | 66
tuberculosis 27 | 2,010
Nystagmus 26 | 317
lung adenocarcinoma 25 | 2,716
subependymal giant cell astrocytoma 25 | 2,287
Schizophrenia 24 | 1,160
colon cancer 23 | 1,478
chronic rhinosinusitis 22 | 512
Asphyxiating thoracic dystrophy 21 | 44
Hypertensive disease 21 | 292
Waldenstrons macroglobulinemia 21 | 765
breast carcinoma 21 | 1,638
dermatomyositis 21 | 966
nasopharyngeal carcinoma 21 | 1,058
Congenital hypoplasia of penis 20 | 176
Electroretinogram abnormal 20 | 95
Retinal Degeneration 20 | 106
group 4 medulloblastoma 20 | 1,855
posterior fossa group B ependymoma 20 | 416
Hypogonadism 19 | 173
Increase in blood pressure 19 | 119
Muscle hypotonia 19 | 571
acute quadriplegic myopathy 19 | 1,158
astrocytoma 19 | 1,146
pediatric high grade glioma 19 | 1,064
Cataract 18 | 297
Meckel syndrome 18 | 46
Senior-Loken syndrome 18 | 22
non primary Sjogren syndrome sicca 18 | 891
pancreatic cancer 18 | 2,398
pituitary cancer 18 | 1,972
progressive supranuclear palsy 18 | 676
Bardet-Biedl syndrome 1 17 | 22
Fundus dystrophy 17 | 83
Lens Opacities 17 | 231
Small head 17 | 374
Ulnar polydactyly of fingers 17 | 47
juvenile dermatomyositis 17 | 1,187
Anteverted nostril 16 | 191
Cerebellar Ataxia 16 | 304
Multicystic Dysplastic Kidney 16 | 52
Rheumatoid arthritis 16 | 1,191
medulloblastoma 16 | 720
ulcerative colitis 16 | 1,819
Abnormality of retinal pigmentation 15 | 111
Epilepsy 15 | 792
Microcephaly 15 | 166
Retinal pigment epithelial abnormality 15 | 111
Seizures 15 | 596
ductal carcinoma in situ 15 | 1,745
lung carcinoma 15 | 2,843
Brachydactyly 14 | 156
Glaucoma 14 | 239
Optic Atrophy 14 | 242
adrenocortical carcinoma 14 | 1,428

Tissue

Endocrine System 260 | 18,159
Digestive Tract 258 | 17,369
Male tissues 258 | 17,142
Skin and soft tissues 258 | 17,230
Female tissues 257 | 17,400
Nervous System 257 | 16,725
Urinary Tract 257 | 16,678
Liver and Pancreas 256 | 16,750
Blood and immune system 255 | 16,909
Respiratory system 255 | 16,393
Cardiovascular System 254 | 15,192

Target Family

Non-IDG 183 | 12,091
Enzyme 32 | 4,145
Kinase 16 | 634
Epigenetic 10 | 242
Transcription Factor 8 | 1,400
GPCR 4 | 408
Ion Channel 4 | 344
Nuclear Receptor 4 | 48

Reactome Pathway

Organelle biogenesis and maint... 261 | 261
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
Centrosomal protein of 83 kDa CEP83 Tdark Non-IDG -0.47180 2.89 0
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Tetratricopeptide repeat protein 30A TTC30A Tdark Non-IDG 0.60 0.00000 57
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
5'-AMP-activated protein kinase subunit gamma-1 PRKAG1 Tbio Kinase -1.00162 9.02 293
Metaxin-1 MTX1 Tbio Non-IDG -1.93920 85.1 64