Development Level

Tbio 50 | 11,445
Tchem 16 | 1,598
Tclin 9 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
male infertility 2 | 123
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
decreased bone mineral content 1 | 151
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened QRS complex duration 1 | 1
small epididymis 1 | 3
small kidney 1 | 16

Disease

Carcinoma 54 | 11,493
medulloblastoma, large-cell 51 | 6,241
glioblastoma 49 | 5,792
atypical teratoid / rhabdoid tumor 43 | 5,112
ovarian cancer 43 | 8,520
osteosarcoma 41 | 7,950
psoriasis 37 | 6,694
ependymoma 34 | 4,679
adult high grade glioma 33 | 3,801
Astrocytoma, Pilocytic 31 | 3,081
group 3 medulloblastoma 31 | 4,104
primitive neuroectodermal tumor 31 | 3,035
Breast cancer 28 | 3,578
subependymal giant cell astrocytoma 27 | 2,287
astrocytic glioma 25 | 2,597
oligodendroglioma 25 | 2,850
lung cancer 23 | 4,740
invasive ductal carcinoma 22 | 2,951
malignant mesothelioma 22 | 3,232
Pick disease 20 | 1,894
Schizophrenia 20 | 1,160
lung carcinoma 20 | 2,843
Depressive disorder 19 | 409
lung adenocarcinoma 19 | 2,716
Bipolar Disorder 16 | 666
Mental Depression 16 | 333
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Kidney cancer 14 | 2,613
colon cancer 14 | 1,478
group 4 medulloblastoma 14 | 1,855
interstitial cystitis 14 | 2,312
Autosomal recessive predisposition 13 | 1,442
Cancer 13 | 2,499
breast carcinoma 13 | 1,638
pancreatic cancer 13 | 2,398
ulcerative colitis 13 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
non-small cell lung cancer 12 | 2,890
tuberculosis 11 | 2,010
Alcoholic Intoxication, Chronic 10 | 289
Epilepsy 10 | 792
Obesity 10 | 678
cystic fibrosis 10 | 1,696
diabetes mellitus 10 | 1,728
ductal carcinoma in situ 10 | 1,745
pituitary cancer 10 | 1,972
Intellectual disability 9 | 1,016
astrocytoma 9 | 1,146
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Major Depressive Disorder 8 | 301
Mental and motor retardation 8 | 608
Multiple myeloma 8 | 1,332
Rheumatoid arthritis 8 | 1,191
Waldenstrons macroglobulinemia 8 | 765
active Crohn's disease 8 | 922
Asthma 7 | 385
Autistic Disorder 7 | 364
Carney complex 7 | 25
Hypertensive disease 7 | 292
Seizures 7 | 596
juvenile dermatomyositis 7 | 1,187
pediatric high grade glioma 7 | 1,064
Atopic dermatitis 6 | 952
Cocaine-Related Disorders 6 | 92
Duchenne muscular dystrophy 6 | 601
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Mood Disorders 6 | 184
Neurodegenerative disease 6 | 414
Parkinson's disease 6 | 392
Poor school performance 6 | 645
Substance Withdrawal Syndrome 6 | 55
Unipolar Depression 6 | 250
acute quadriplegic myopathy 6 | 1,158
adrenocortical carcinoma 6 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Acquired metabolic disease 5 | 336
Alcohol dependence 5 | 107
Chronic obstructive pulmonary disease 5 | 184
Cocaine Dependence 5 | 51
Hypertension 5 | 396
Liver Cirrhosis, Experimental 5 | 769
Liver cancer 5 | 604
Melanoma 5 | 711
Osteoporosis 5 | 363
Primary pigmented nodular adrenocortical disease 5 | 13
Prostatic Neoplasms 5 | 495
aldosterone-producing adenoma 5 | 665
cutaneous lupus erythematosus 5 | 1,057
non primary Sjogren syndrome sicca 5 | 891
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109
sarcoidosis 5 | 370
Myocardial Ischemia 4 | 169
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
spina bifida 4 | 1,074

Tissue

Endocrine System 79 | 18,159
Digestive Tract 78 | 17,369
Blood and immune system 76 | 16,909
Male tissues 76 | 17,142
Nervous System 76 | 16,725
Skin and soft tissues 76 | 17,230
Female tissues 75 | 17,400
Liver and Pancreas 74 | 16,750
Respiratory system 73 | 16,393
Urinary Tract 72 | 16,678
Cardiovascular System 71 | 15,192

Target Family

Enzyme 35 | 4,145
Non-IDG 29 | 12,091
Kinase 10 | 634
Ion Channel 3 | 344
GPCR 1 | 408
Transcription Factor 1 | 1,400

Reactome Pathway

Opioid Signalling 79 | 79
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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