Development Level

Tbio 46 | 10,625
Tdark 14 | 7,003
Tchem 6 | 1,890

IMPC Term

increased exploration in new e... 2 | 56
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased Ly6C high monocyte n... 1 | 12
increased circulating fructosa... 1 | 11
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
short tibia 1 | 82

Disease

ovarian cancer 32 | 8,484
osteosarcoma 26 | 7,933
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
lung adenocarcinoma 25 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
psoriasis 24 | 6,685
pancreatic cancer 19 | 2,300
Breast cancer 18 | 3,094
cystic fibrosis 16 | 1,665
glioblastoma 16 | 5,572
medulloblastoma, large-cell 16 | 6,234
pilocytic astrocytoma 16 | 3,086
pituitary cancer 16 | 1,972
lung cancer 13 | 4,466
invasive ductal carcinoma 12 | 2,950
nasopharyngeal carcinoma 12 | 1,056
active Crohn's disease 11 | 918
atypical teratoid / rhabdoid tumor 11 | 4,369
Carcinoma 10 | 2,147
malignant mesothelioma 10 | 3,162
non-small cell lung cancer 10 | 2,798
posterior fossa group A ependymoma 10 | 1,511
ulcerative colitis 10 | 2,087
Cancer 9 | 2,346
breast carcinoma 9 | 1,614
interstitial cystitis 9 | 2,299
oligodendroglioma 9 | 2,849
primitive neuroectodermal tumor 9 | 3,031
astrocytic glioma 8 | 2,241
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 2,254
group 4 medulloblastoma 8 | 1,875
lung carcinoma 8 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
pediatric high grade glioma 8 | 2,712
spina bifida 8 | 1,064
Atopic dermatitis 7 | 944
esophageal adenocarcinoma 7 | 737
active ulcerative colitis 6 | 477
adult high grade glioma 6 | 2,148
atypical teratoid/rhabdoid tumor 6 | 1,095
diabetes mellitus 6 | 1,663
posterior fossa group B ependymoma 6 | 1,530
IGA Glomerulonephritis 5 | 454
Multiple myeloma 5 | 1,327
colon cancer 5 | 1,475
non primary Sjogren syndrome sicca 5 | 840
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 165
Biliary papillomatosis 4 | 4
Otitis media 4 | 32
Rheumatoid Arthritis 4 | 1,160
astrocytoma 4 | 1,493
cutaneous lupus erythematosus 4 | 1,056
facioscapulohumeral dystrophy 4 | 286
gastric carcinoma 4 | 832
interstitial lung disease 4 | 291
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
primary pancreatic ductal adenocarcinoma 4 | 1,271
Amyotrophic Lateral Sclerosis 3 | 431
Asthma 3 | 349
Bilateral breast cancer 3 | 4
Gastritis 3 | 44
Pick disease 3 | 1,893
Prostatic Neoplasms 3 | 471
Systemic scleroderma 3 | 66
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,427
chronic rhinosinusitis 3 | 512
ependymoma 3 | 2,514
fibroadenoma 3 | 557
juvenile dermatomyositis 3 | 1,189
medulloblastoma 3 | 1,524
primary Sjogren syndrome 3 | 789
sonic hedgehog group medulloblastoma 3 | 1,482
urothelial carcinoma 3 | 318
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Barrett's esophagus 2 | 183
Bronchitis 2 | 44
Chronic obstructive pulmonary disease 2 | 146
Common cold 2 | 63
Influenza 2 | 142
Multiple Sclerosis 2 | 498
Pneumonia 2 | 133
Primary ciliary dyskinesia 2 | 73
Stomach Neoplasms 2 | 282
Type 2 diabetes mellitus 2 | 189
Williams-Beuren syndrome 2 | 45
acute myeloid leukemia 2 | 780
acute quadriplegic myopathy 2 | 1,157
aldosterone-producing adenoma 2 | 664
dermatomyositis 2 | 933
inflammatory breast cancer 2 | 404
periodontitis 2 | 269
tuberculosis 2 | 1,557
tuberculosis and treatment for 6 months 2 | 686
uncontrolled asthma 2 | 67

Tissue

Digestive Tract 63 | 18,473
Liver and Pancreas 63 | 18,136
Urinary Tract 63 | 18,444
Cardiovascular System 62 | 17,958
Endocrine System 62 | 18,512
Female tissues 62 | 18,647
Male tissues 62 | 17,969
Nervous System 62 | 18,561
Respiratory system 62 | 17,484
Skin and soft tissues 62 | 18,115
Blood and immune system 61 | 17,995

Target Family

Enzyme 48 | 4,146
Non-IDG 18 | 11,971

Reactome Pathway

O-linked glycosylation of muci... 66 | 66
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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