Development Level

Tbio 94 | 11,445
Tdark 14 | 6,588
Tchem 5 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

decreased vertical activity 4 | 208
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased circulating insulin ... 2 | 76
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal lymph node morphology 1 | 3
abnormal nail morphology 1 | 8
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
short tibia 1 | 97

Disease

Carcinoma 95 | 11,493
ovarian cancer 53 | 8,520
osteosarcoma 50 | 7,950
Breast cancer 37 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
lung adenocarcinoma 37 | 2,716
psoriasis 37 | 6,694
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
Kidney cancer 33 | 2,613
glioblastoma 32 | 5,792
medulloblastoma, large-cell 32 | 6,241
pancreatic cancer 31 | 2,398
lung cancer 30 | 4,740
atypical teratoid / rhabdoid tumor 29 | 5,112
ependymoma 29 | 4,679
cystic fibrosis 26 | 1,696
pituitary cancer 26 | 1,972
non-small cell lung cancer 25 | 2,890
invasive ductal carcinoma 24 | 2,951
Astrocytoma, Pilocytic 23 | 3,081
interstitial cystitis 23 | 2,312
malignant mesothelioma 22 | 3,232
adult high grade glioma 21 | 3,801
group 4 medulloblastoma 20 | 1,855
lung carcinoma 20 | 2,843
group 3 medulloblastoma 19 | 4,104
astrocytic glioma 17 | 2,597
oligodendroglioma 16 | 2,850
active Crohn's disease 15 | 922
nasopharyngeal carcinoma 15 | 1,058
ductal carcinoma in situ 14 | 1,745
primitive neuroectodermal tumor 14 | 3,035
active ulcerative colitis 13 | 764
breast carcinoma 13 | 1,638
colon cancer 13 | 1,478
ulcerative colitis 13 | 1,819
Cancer 12 | 2,499
adrenocortical carcinoma 12 | 1,428
Liver cancer 11 | 604
gastric carcinoma 11 | 807
primary pancreatic ductal adenocarcinoma 11 | 1,109
Acquired metabolic disease 10 | 336
Autosomal recessive predisposition 10 | 1,442
Melanoma 10 | 711
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
subependymal giant cell astrocytoma 10 | 2,287
Congenital muscular dystrophy 9 | 29
Lissencephaly 9 | 69
Muscular dystrophy 9 | 75
Walker-Warburg congenital muscular dystrophy 9 | 14
Walker-Warburg syndrome 9 | 20
diabetes mellitus 9 | 1,728
esophageal adenocarcinoma 9 | 737
Atopic dermatitis 8 | 952
Myopia 8 | 176
Skin cancer 8 | 469
atypical teratoid/rhabdoid tumor 8 | 357
pediatric high grade glioma 8 | 1,064
spina bifida 8 | 1,074
Epilepsy 7 | 792
Hydrocephalus 7 | 152
Hydrolethalus syndrome 7 | 128
Large intestine cancer 7 | 126
Schizophrenia 7 | 1,160
Weill-Marchesani syndrome 7 | 14
fibroadenoma 7 | 559
posterior fossa group A ependymoma 7 | 468
tuberculosis 7 | 2,010
Cataract 6 | 297
Cognitive delay 6 | 608
Creatine phosphokinase serum increased 6 | 110
Elevated creatine kinase 6 | 110
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Lens Opacities 6 | 231
Mental and motor retardation 6 | 608
Muscle biopsy shows dystrophic changes 6 | 39
Muscle hypotonia 6 | 571
Seizures 6 | 596
interstitial lung disease 6 | 298
Abnormally small eyeball 5 | 97
Crohn's disease 5 | 321
Decreased size of eyeball 5 | 97
Dull intelligence 5 | 645
Glaucoma 5 | 239
Hydrophthalmos 5 | 19
Multiple myeloma 5 | 1,332
Myopathy 5 | 185
Pick disease 5 | 1,894
Polymicrogyria 5 | 48
Prostatic Neoplasms 5 | 495
Retinal Dysplasia 5 | 11
Severe mental retardation (I.Q. 20-34) 5 | 99
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
juvenile dermatomyositis 5 | 1,187
limb-girdle muscular dystrophy 5 | 37
medulloblastoma 5 | 720
pancreatic carcinoma 5 | 562

Tissue

Digestive Tract 107 | 17,369
Female tissues 106 | 17,400
Skin and soft tissues 106 | 17,230
Endocrine System 105 | 18,159
Respiratory system 102 | 16,393
Blood and immune system 101 | 16,909
Urinary Tract 101 | 16,678
Liver and Pancreas 100 | 16,750
Male tissues 100 | 17,142
Nervous System 99 | 16,725
Cardiovascular System 86 | 15,192

Target Family

Enzyme 76 | 4,145
Non-IDG 36 | 12,091
Kinase 1 | 634

Reactome Pathway

O-linked glycosylation 113 | 113
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
Mucin-12 MUC12 Tbio Non-IDG -1.01744 9.74 60
Spondin-2 SPON2 Tbio Non-IDG -1.73555 56.2 210
Mucin-16 MUC16 Tbio Non-IDG -2.09951 138.4 0
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
A disintegrin and metalloproteinase with thrombospondin motifs 7 ADAMTS7 Tbio Enzyme -1.43732 33.7 98
Protein O-mannosyl-transferase 1 POMT1 Tbio Enzyme -1.57372 38.3 123
A disintegrin and metalloproteinase with thrombospondin motifs 14 ADAMTS14 Tbio Enzyme -0.89572 7.58 29
A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAMTS1 Tchem Enzyme -2.44459 279.8 227
Semaphorin-5A SEMA5A Tbio Non-IDG -1.82162 69.8 238