Development Level

Tbio 86 | 10,625
Tdark 20 | 7,003
Tchem 9 | 1,890

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

enlarged heart 3 | 111
abnormal heart morphology 2 | 51
decreased circulating glucose ... 2 | 121
increased exploration in new e... 2 | 56
preweaning lethality, complete... 2 | 633
short tibia 2 | 82
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal lymph node morphology 1 | 3
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
cataract 1 | 26
decreased CD11b-low dendritic ... 1 | 3
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased circulating alanine ... 1 | 53
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased total body fat amoun... 1 | 186
enlarged spleen 1 | 26
increased CD11b-high dendritic... 1 | 5
increased Ly6C high monocyte n... 1 | 12
increased bone mineral content 1 | 92
increased circulating fructosa... 1 | 11
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 52 | 8,491
osteosarcoma 50 | 7,933
psoriasis 38 | 6,685
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
lung adenocarcinoma 37 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
glioblastoma 32 | 5,572
medulloblastoma, large-cell 32 | 6,234
Breast cancer 29 | 3,098
pancreatic cancer 28 | 2,300
Carcinoma 26 | 2,147
lung cancer 26 | 4,473
pituitary cancer 26 | 1,972
cystic fibrosis 25 | 1,670
atypical teratoid / rhabdoid tumor 24 | 4,369
invasive ductal carcinoma 24 | 2,950
pilocytic astrocytoma 24 | 3,086
interstitial cystitis 23 | 2,299
non-small cell lung cancer 23 | 2,798
malignant mesothelioma 21 | 3,163
lung carcinoma 20 | 2,844
pediatric high grade glioma 19 | 2,712
posterior fossa group A ependymoma 19 | 1,511
group 4 medulloblastoma 17 | 1,875
astrocytic glioma 16 | 2,241
oligodendroglioma 16 | 2,849
ulcerative colitis 16 | 2,087
active Crohn's disease 15 | 918
nasopharyngeal carcinoma 15 | 1,056
ductal carcinoma in situ 14 | 1,745
group 3 medulloblastoma 14 | 2,254
primitive neuroectodermal tumor 14 | 3,031
atypical teratoid/rhabdoid tumor 13 | 1,095
breast carcinoma 13 | 1,614
colon cancer 13 | 1,475
Cancer 12 | 2,346
adrenocortical carcinoma 12 | 1,427
posterior fossa group B ependymoma 12 | 1,530
primary pancreatic ductal adenocarcinoma 12 | 1,271
gastric carcinoma 11 | 832
active ulcerative colitis 10 | 477
adult high grade glioma 10 | 2,148
subependymal giant cell astrocytoma 10 | 2,287
Lissencephaly 9 | 61
Walker-Warburg congenital muscular dystrophy 9 | 14
Walker-Warburg syndrome 9 | 18
diabetes mellitus 9 | 1,663
esophageal adenocarcinoma 9 | 737
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
sonic hedgehog group medulloblastoma 9 | 1,482
Acquired metabolic disease 8 | 267
Atopic dermatitis 8 | 944
Congenital muscular dystrophy 8 | 25
ependymoma 8 | 2,514
spina bifida 8 | 1,064
Hydrolethalus syndrome 7 | 128
Muscular dystrophy 7 | 48
Weill-Marchesani syndrome 7 | 14
fibroadenoma 7 | 557
IGA Glomerulonephritis 6 | 454
astrocytoma 6 | 1,493
interstitial lung disease 6 | 292
medulloblastoma 6 | 1,524
tuberculosis 6 | 1,563
Alzheimer's disease 5 | 644
Hydrocephalus 5 | 60
Intellectual disability 5 | 573
Multiple myeloma 5 | 1,327
Muscle eye brain disease 5 | 8
Muscle-eye-brain disease 5 | 8
Pick disease 5 | 1,893
Prostatic Neoplasms 5 | 471
Schizophrenia 5 | 503
cutaneous lupus erythematosus 5 | 1,056
facioscapulohumeral dystrophy 5 | 286
inflammatory breast cancer 5 | 404
juvenile dermatomyositis 5 | 1,189
limb-girdle muscular dystrophy 5 | 36
non primary Sjogren syndrome sicca 5 | 840
non-small cell lung carcinoma 5 | 413
pancreatic carcinoma 5 | 567
Adenoma 4 | 165
Amyotrophic Lateral Sclerosis 4 | 432
Arthritis 4 | 248
Biliary papillomatosis 4 | 4
Brachydactyly 4 | 52
Endometriosis 4 | 535
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain and Eye Anomalies), Type A, 1 4 | 6
Otitis media 4 | 32
Rheumatoid Arthritis 4 | 1,170
Type 2 diabetes mellitus 4 | 192
chronic rhinosinusitis 4 | 512
Crohn's disease 3 | 304
Waldenstrons macroglobulinemia 3 | 764
acute myeloid leukemia 3 | 785
aldosterone-producing adenoma 3 | 664
mucosa-associated lymphoid tissue lymphoma 3 | 480
non diabetic and post-ischemic heart failure 3 | 200
primary Sjogren syndrome 3 | 788

Tissue

Digestive Tract 112 | 18,472
Liver and Pancreas 112 | 18,135
Urinary Tract 112 | 18,443
Male tissues 111 | 17,968
Blood and immune system 110 | 17,994
Cardiovascular System 110 | 17,957
Endocrine System 110 | 18,511
Female tissues 110 | 18,646
Nervous System 110 | 18,560
Respiratory system 110 | 17,483
Skin and soft tissues 109 | 18,114

Target Family

Enzyme 78 | 4,146
Non-IDG 36 | 11,969
Kinase 1 | 634

Reactome Pathway

O-linked glycosylation 115 | 115
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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