Development Level

Tbio 31 | 11,445
Tdark 5 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased vertical activity 2 | 208
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal lymph node morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
increased bone mineral content 1 | 108
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

Carcinoma 32 | 11,493
Kidney cancer 18 | 2,613
osteosarcoma 18 | 7,950
ovarian cancer 17 | 8,520
Breast cancer 15 | 3,578
interstitial cystitis 14 | 2,312
glioblastoma 13 | 5,792
medulloblastoma, large-cell 12 | 6,241
ependymoma 11 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
invasive ductal carcinoma 11 | 2,951
lung cancer 11 | 4,740
non-small cell lung cancer 11 | 2,890
pancreatic cancer 11 | 2,398
psoriasis 11 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
cystic fibrosis 10 | 1,696
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung adenocarcinoma 10 | 2,716
lung carcinoma 10 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
adrenocortical carcinoma 8 | 1,428
adult high grade glioma 8 | 3,801
malignant mesothelioma 8 | 3,232
Acquired metabolic disease 7 | 336
Astrocytoma, Pilocytic 7 | 3,081
Weill-Marchesani syndrome 7 | 14
astrocytic glioma 7 | 2,597
pituitary cancer 7 | 1,972
Melanoma 6 | 711
Skin cancer 6 | 469
colon cancer 6 | 1,478
gastric carcinoma 6 | 807
group 4 medulloblastoma 6 | 1,855
oligodendroglioma 6 | 2,850
primary pancreatic ductal adenocarcinoma 6 | 1,109
Liver cancer 5 | 604
Schizophrenia 5 | 1,160
atypical teratoid/rhabdoid tumor 5 | 357
ductal carcinoma in situ 5 | 1,745
posterior fossa group A ependymoma 5 | 468
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Hydrolethalus syndrome 4 | 128
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
fibroadenoma 4 | 559
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Arthritis 3 | 290
Brachydactyly 3 | 156
Congestive heart failure 3 | 113
Degenerative disc disease 3 | 35
Hepatomegaly 3 | 285
Kidney disease 3 | 430
Myopia 3 | 176
Osteoarthritis 3 | 184
Parkinson's disease 3 | 392
Short stature 3 | 531
Tracheal stenosis 3 | 23
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
nasopharyngeal carcinoma 3 | 1,058
non diabetic and post-ischemic heart failure 3 | 200
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Alcoholic Intoxication, Chronic 2 | 289
Alzheimer's disease 2 | 658
Cancer 2 | 2,499
Cardiovascular system disease 2 | 246
Cerebrovascular disease 2 | 238
Congenital Epicanthus 2 | 177
Congenital disorder of glycosylation 2 | 54
Crohn's disease 2 | 321
Diabetic Angiopathies 2 | 16
Downward slant of palpebral fissure 2 | 158
Ehlers-Danlos syndrome 2 | 43
Endometriosis 2 | 540
Generalized osteopenia 2 | 99
Joint stiffness 2 | 84
Large intestine cancer 2 | 126
Macular degeneration 2 | 65
Osteopenia 2 | 99
Polycystic ovary syndrome 2 | 360
Proteinuria 2 | 144
Round face 2 | 45
Round, full face 2 | 45
Type 2 diabetes mellitus 2 | 272
adrenocortical adenoma 2 | 131
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
esophageal adenocarcinoma 2 | 737
head and neck cancer 2 | 271
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
interstitial lung disease 2 | 298
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Nervous System 37 | 16,725
Digestive Tract 36 | 17,369
Male tissues 36 | 17,142
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Cardiovascular System 35 | 15,192
Liver and Pancreas 35 | 16,750
Respiratory system 35 | 16,393
Blood and immune system 34 | 16,909

Target Family

Enzyme 20 | 4,145
Non-IDG 18 | 12,091

Reactome Pathway

O-glycosylation of TSR domain-... 38 | 38
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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