Development Level

Tchem 24 | 1,598
Tbio 20 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased circulating calcium ... 2 | 34
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal lens morphology 1 | 81
abnormal tooth morphology 1 | 24
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
premature death 1 | 5
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 36 | 11,493
ovarian cancer 28 | 8,520
osteosarcoma 27 | 7,950
psoriasis 27 | 6,694
Cancer 26 | 2,499
glioblastoma 23 | 5,792
lung cancer 22 | 4,740
medulloblastoma, large-cell 18 | 6,241
atypical teratoid / rhabdoid tumor 16 | 5,112
malignant mesothelioma 15 | 3,232
non-small cell lung cancer 14 | 2,890
adult high grade glioma 13 | 3,801
ependymoma 13 | 4,679
lung carcinoma 13 | 2,843
tuberculosis 13 | 2,010
oligodendroglioma 12 | 2,850
Arthritis 10 | 290
Breast cancer 10 | 3,578
invasive ductal carcinoma 10 | 2,951
pancreatic cancer 10 | 2,398
subependymal giant cell astrocytoma 10 | 2,287
group 3 medulloblastoma 9 | 4,104
juvenile dermatomyositis 9 | 1,187
Astrocytoma, Pilocytic 8 | 3,081
Bipolar Disorder 8 | 666
Kidney cancer 8 | 2,613
cutaneous lupus erythematosus 8 | 1,057
cystic fibrosis 8 | 1,696
diabetes mellitus 8 | 1,728
gastric cancer 8 | 459
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
ulcerative colitis 8 | 1,819
Multiple myeloma 7 | 1,332
Rheumatoid arthritis 7 | 1,191
Vascular disease 7 | 319
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Crohn's disease 6 | 321
Familial cold autoinflammatory syndrome 6 | 10
Liver Cirrhosis, Experimental 6 | 769
Muckle-Wells syndrome 6 | 12
Neurodegenerative disease 6 | 414
Pick disease 6 | 1,894
acute quadriplegic myopathy 6 | 1,158
astrocytic glioma 6 | 2,597
lung adenocarcinoma 6 | 2,716
pancreatic carcinoma 6 | 562
primitive neuroectodermal tumor 6 | 3,035
Alzheimer's disease 5 | 658
Blau syndrome 5 | 9
Inflammatory bowel disease 5 | 151
Lung Neoplasms 5 | 232
Multiple Sclerosis 5 | 540
Waldenstrons macroglobulinemia 5 | 765
colon cancer 5 | 1,478
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
medulloblastoma 5 | 720
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
posterior fossa group A ependymoma 5 | 468
primary Sjogren syndrome 5 | 735
sarcoidosis 5 | 370
Amyotrophic lateral sclerosis 4 | 451
Arthritis, Rheumatoid 4 | 174
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Hepatocellular 4 | 228
Cerebral Hemorrhage 4 | 42
Chronic Lymphocytic Leukemia 4 | 262
Epilepsy 4 | 792
Fatigue 4 | 182
Fever 4 | 138
Liver carcinoma 4 | 240
Peritonitis 4 | 43
Polycystic ovary syndrome 4 | 360
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Splenomegaly 4 | 190
Stomach Neoplasms 4 | 300
Toxic encephalopathy 4 | 141
X-linked lymphoproliferative syndrome 2 4 | 4
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
spina bifida 4 | 1,074
Atopic dermatitis 3 | 952
Contact Dermatitis 3 | 81
Depressive disorder 3 | 409
Dermatitis, Contact 3 | 71
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Hypersensitivity reaction type II disease 3 | 253
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
mucosa-associated lymphoid tissue lymphoma 3 | 484
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Nervous System 46 | 16,725
Respiratory system 46 | 16,393
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678

Target Family

Non-IDG 20 | 12,091
Kinase 13 | 634
Enzyme 11 | 4,145
Ion Channel 2 | 344

Reactome Pathway

Nucleotide-binding domain, leu... 46 | 46
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.29685 1936.6 519
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Protein SGT1 homolog SUGT1 Tbio Non-IDG -0.79781 9.93 183
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Pyrin MEFV Tbio Non-IDG -3.02735 980.3 176
Caspase-4 CASP4 Tchem Enzyme -2.19377 147.3 520
Proline-serine-threonine phosphatase-interacting protein 1 PSTPIP1 Tbio Enzyme -1.89883 82.3 119
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313