Development Level

Tbio 84 | 10,625
Tchem 12 | 1,890
Tdark 10 | 7,003
Tclin 4 | 602

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 5 | 187
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
hypoactivity 2 | 89
increased body weight 2 | 42
increased heart weight 2 | 37
abnormal QRS complex 1 | 25
abnormal embryo turning 1 | 15
abnormal liver size 1 | 4
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
decreased body weight 1 | 174
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
pale yolk sac 1 | 12
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26

Disease

ovarian cancer 70 | 8,484
osteosarcoma 48 | 7,933
lung cancer 37 | 4,466
Cancer 32 | 2,346
psoriasis 31 | 6,685
medulloblastoma, large-cell 29 | 6,234
malignant mesothelioma 27 | 3,162
Cockayne syndrome 26 | 54
Xeroderma pigmentosum 23 | 41
group 3 medulloblastoma 22 | 2,254
glioblastoma 21 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
Multiple myeloma 18 | 1,327
atypical teratoid / rhabdoid tumor 18 | 4,369
primitive neuroectodermal tumor 17 | 3,031
Waldenstrons macroglobulinemia 15 | 765
non-small cell lung cancer 15 | 2,798
Photosensitive trichothiodystrophy 14 | 24
Breast cancer 13 | 3,094
Carcinoma 13 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
oligodendroglioma 13 | 2,849
acute myeloid leukemia 12 | 780
diabetes mellitus 12 | 1,663
ependymoma 12 | 2,514
Pick disease 10 | 1,893
pediatric high grade glioma 10 | 2,712
adult high grade glioma 9 | 2,148
astrocytic glioma 9 | 2,241
astrocytoma 9 | 1,493
lung adenocarcinoma 9 | 2,713
Peripheral Neuropathy 8 | 303
Rheumatoid Arthritis 8 | 1,160
atypical teratoid/rhabdoid tumor 8 | 1,095
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
pituitary cancer 8 | 1,972
Intellectual disability 7 | 573
Stomach Neoplasms 7 | 282
invasive ductal carcinoma 7 | 2,950
nasopharyngeal carcinoma 7 | 1,056
Alzheimer's disease 6 | 644
dermatomyositis 6 | 933
hepatocellular carcinoma 6 | 532
pancreatic cancer 6 | 2,300
sonic hedgehog group medulloblastoma 6 | 1,482
tuberculosis and treatment for 6 months 6 | 686
Bladder Neoplasm 5 | 109
Colorectal Neoplasms 5 | 217
Disease Progression 5 | 125
Stevens-Johnson syndrome 5 | 78
UV-sensitive syndrome 5 | 7
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
non primary Sjogren syndrome sicca 5 | 840
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
subependymal giant cell astrocytoma 5 | 2,287
Arsenic Poisoning 4 | 59
CAMFAK syndrome 4 | 4
Cerebrooculofacioskeletal Syndrome 1 4 | 4
Lung Neoplasms 4 | 171
Malignant tumor of ovary 4 | 25
Micronuclei, Chromosome-Defective 4 | 19
Neurodegenerative disease 4 | 383
Pena Shokeir syndrome Type 2 4 | 4
Prostatic Neoplasms 4 | 471
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
ductal carcinoma in situ 4 | 1,745
gastric cancer 4 | 430
lung carcinoma 4 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group A ependymoma 4 | 1,511
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
Animal Mammary Neoplasms 3 | 136
Cataract 3 | 104
Cerebrovascular disease 3 | 231
Cockayne Syndrome, Type I 3 | 3
Cockayne Syndrome, Type II 3 | 3
Craniofacial Abnormalities 3 | 147
Down syndrome 3 | 548
Fanconi's anemia 3 | 50
IGA Glomerulonephritis 3 | 454
Mammary Neoplasms, Experimental 3 | 150
Melanoma 3 | 261
Obesity 3 | 616
Progeria 3 | 22
Trichothiodystrophy Syndromes 3 | 5
Uterine Cervical Neoplasm 3 | 21
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
group 4 medulloblastoma 3 | 1,875
pancreatic carcinoma 3 | 567
progressive supranuclear palsy 3 | 674
tuberculosis 3 | 1,557
Brain Ischemia 2 | 87
Endometriosis 2 | 535
Prostate cancer 2 | 172
inflammatory breast cancer 2 | 404

Tissue

Blood and immune system 110 | 17,995
Cardiovascular System 110 | 17,958
Digestive Tract 110 | 18,473
Endocrine System 110 | 18,512
Female tissues 110 | 18,647
Liver and Pancreas 110 | 18,136
Male tissues 110 | 17,969
Nervous System 110 | 18,561
Respiratory system 110 | 17,484
Skin and soft tissues 110 | 18,115
Urinary Tract 110 | 18,444

Target Family

Non-IDG 67 | 11,971
Enzyme 38 | 4,146
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Nucleotide Excision Repair 110 | 110
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.17350 165.7 375