Development Level

Tbio 84 | 10,625
Tchem 12 | 1,890
Tdark 10 | 7,003
Tclin 4 | 602

IMPC Phenotype

preweaning lethality, complete... 11 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 5 | 187
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
hypoactivity 2 | 89
increased body weight 2 | 42
increased heart weight 2 | 37
abnormal QRS complex 1 | 25
abnormal embryo turning 1 | 15
abnormal liver size 1 | 4
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
decreased body weight 1 | 174
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
pale yolk sac 1 | 12
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26

Disease

ovarian cancer 70 | 8,491
osteosarcoma 48 | 7,933
lung cancer 38 | 4,473
Cancer 32 | 2,346
psoriasis 31 | 6,685
medulloblastoma, large-cell 29 | 6,234
malignant mesothelioma 27 | 3,163
Cockayne syndrome 26 | 54
Xeroderma pigmentosum 23 | 41
group 3 medulloblastoma 22 | 2,254
glioblastoma 21 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
Multiple myeloma 18 | 1,327
atypical teratoid / rhabdoid tumor 18 | 4,369
primitive neuroectodermal tumor 17 | 3,031
Waldenstrons macroglobulinemia 15 | 764
non-small cell lung cancer 15 | 2,798
Photosensitive trichothiodystrophy 14 | 24
Breast cancer 13 | 3,098
Carcinoma 13 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
oligodendroglioma 13 | 2,849
acute myeloid leukemia 12 | 785
diabetes mellitus 12 | 1,663
ependymoma 12 | 2,514
Pick disease 10 | 1,893
pediatric high grade glioma 10 | 2,712
adult high grade glioma 9 | 2,148
astrocytic glioma 9 | 2,241
astrocytoma 9 | 1,493
lung adenocarcinoma 9 | 2,714
Peripheral Neuropathy 8 | 303
Rheumatoid Arthritis 8 | 1,170
atypical teratoid/rhabdoid tumor 8 | 1,095
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
pituitary cancer 8 | 1,972
Intellectual disability 7 | 573
Stomach Neoplasms 7 | 282
invasive ductal carcinoma 7 | 2,950
nasopharyngeal carcinoma 7 | 1,056
Alzheimer's disease 6 | 644
dermatomyositis 6 | 966
hepatocellular carcinoma 6 | 550
pancreatic cancer 6 | 2,300
sonic hedgehog group medulloblastoma 6 | 1,482
tuberculosis and treatment for 6 months 6 | 686
Bladder Neoplasm 5 | 109
Colorectal Neoplasms 5 | 217
Disease Progression 5 | 125
Stevens-Johnson syndrome 5 | 91
UV-sensitive syndrome 5 | 7
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
non primary Sjogren syndrome sicca 5 | 840
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
subependymal giant cell astrocytoma 5 | 2,287
Arsenic Poisoning 4 | 59
CAMFAK syndrome 4 | 4
COFS syndrome 4 | 4
Cerebrooculofacioskeletal Syndrome 1 4 | 4
Lung Neoplasms 4 | 171
Malignant tumor of ovary 4 | 25
Micronuclei, Chromosome-Defective 4 | 20
Neurodegenerative disease 4 | 383
Pena Shokeir syndrome Type 2 4 | 4
Prostatic Neoplasms 4 | 471
Xeroderma pigmentosum-Cockayne syndrome complex 4 | 4
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
ductal carcinoma in situ 4 | 1,745
gastric cancer 4 | 436
lung carcinoma 4 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group A ependymoma 4 | 1,511
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
Animal Mammary Neoplasms 3 | 135
Cataract 3 | 104
Cerebro-oculo-facio-skeletal syndrome 3 | 3
Cerebrovascular disease 3 | 231
Cockayne Syndrome, Type I 3 | 3
Cockayne Syndrome, Type II 3 | 3
Craniofacial Abnormalities 3 | 147
Down syndrome 3 | 548
Fanconi's anemia 3 | 50
IGA Glomerulonephritis 3 | 454
Mammary Neoplasms, Experimental 3 | 149
Melanoma 3 | 261
Obesity 3 | 616
Progeria 3 | 22
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
Uterine Cervical Neoplasm 3 | 21
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
group 4 medulloblastoma 3 | 1,875
pancreatic carcinoma 3 | 567
progressive supranuclear palsy 3 | 674
tuberculosis 3 | 1,563

Tissue

Blood and immune system 110 | 17,994
Cardiovascular System 110 | 17,957
Digestive Tract 110 | 18,472
Endocrine System 110 | 18,511
Female tissues 110 | 18,646
Liver and Pancreas 110 | 18,135
Male tissues 110 | 17,968
Nervous System 110 | 18,560
Respiratory system 110 | 17,483
Skin and soft tissues 110 | 18,114
Urinary Tract 110 | 18,443

Target Family

Non-IDG 67 | 11,969
Enzyme 38 | 4,146
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Nucleotide Excision Repair 110 | 110
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
UV-stimulated scaffold protein A UVSSA Tbio Non-IDG -0.81845 7.77 23
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.18675 151.0 193
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.35799 23.9 89
COP9 signalosome complex subunit 3 COPS3 Tbio Non-IDG -1.07542 12.3 193
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.30532 19.4 143
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69416 474.2 685
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 6.02 65