Development Level

Tbio 92 | 11,651
Tchem 7 | 1,388
Tdark 7 | 6,593
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 6 | 278
abnormal seminal vesicle morph... 3 | 114
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
enlarged heart 2 | 210
increased body weight 2 | 25
increased mean corpuscular hem... 2 | 36
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal heart shape 1 | 5
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fluid intake 1 | 3
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

ovarian cancer 69 | 8,520
Carcinoma 59 | 11,493
osteosarcoma 47 | 7,950
lung cancer 41 | 4,740
Cancer 32 | 2,499
Cockayne syndrome 31 | 60
psoriasis 31 | 6,694
medulloblastoma, large-cell 28 | 6,241
group 3 medulloblastoma 27 | 4,104
malignant mesothelioma 27 | 3,232
atypical teratoid / rhabdoid tumor 22 | 5,112
glioblastoma 22 | 5,792
Xeroderma pigmentosum 20 | 43
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Multiple myeloma 17 | 1,332
ependymoma 17 | 4,679
Breast cancer 16 | 3,578
primitive neuroectodermal tumor 16 | 3,035
Photosensitive trichothiodystrophy 15 | 30
Waldenstrons macroglobulinemia 15 | 765
adult high grade glioma 15 | 3,801
non-small cell lung cancer 15 | 2,890
Intellectual disability 14 | 1,016
Kidney cancer 13 | 2,613
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
oligodendroglioma 13 | 2,850
Autosomal recessive predisposition 12 | 1,442
Cataract 12 | 297
Cryptorchidism 12 | 296
Hypogonadism 12 | 173
Sensorineural Hearing Loss (disorder) 12 | 284
acute myeloid leukemia 12 | 783
Lens Opacities 11 | 231
Photosensitivity of skin 11 | 51
Short stature 11 | 531
Strabismus 11 | 270
Dull intelligence 10 | 645
Low intelligence 10 | 645
Melanoma 10 | 711
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Pick disease 10 | 1,894
Poor school performance 10 | 645
Small head 10 | 374
Atrophic condition of skin 9 | 25
Dry skin 9 | 75
Electroencephalogram abnormal 9 | 101
Failure to gain weight 9 | 365
Freckles 9 | 33
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Optic Atrophy 9 | 242
Pediatric failure to thrive 9 | 365
Xeroderma pigmentosum group B 9 | 20
Xerosis 9 | 75
astrocytic glioma 9 | 2,597
Arthralgia 8 | 90
Cerebellar Ataxia 8 | 304
Conjunctival telangiectasis 8 | 14
Epilepsy 8 | 792
Erythema 8 | 58
Keratitis 8 | 62
Poikiloderma 8 | 14
Seizures 8 | 596
Stomach Neoplasms 8 | 300
Xeroderma pigmentosum group D 8 | 33
astrocytoma 8 | 1,146
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
Basal cell carcinoma 7 | 54
Dental abnormalities 7 | 60
Developmental regression 7 | 95
Fatigue 7 | 182
Fever 7 | 138
Flushing 7 | 60
Hyperkeratosis 7 | 50
Hyperpigmented macules 7 | 42
Impaired cognition 7 | 96
Loss of developmental milestones 7 | 95
Mental deterioration in childhood 7 | 95
Mental impairment 7 | 95
Muscle Spasticity 7 | 195
Muscle hypotonia 7 | 571
Neurodevelopmental regression 7 | 95
Papilloma 7 | 44
Progressive mental retardation 7 | 37
Psychomotor regression 7 | 95
Psychomotor regression beginning in infancy 7 | 95
Psychomotor regression in infants 7 | 95
Psychomotor regression, progressive 7 | 95
Rheumatoid arthritis 7 | 1,191
Telangiectasia of the skin 7 | 39
Thin skin 7 | 47
Tooth Abnormalities 7 | 69
hypopigmented skin patch 7 | 59
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
nasopharyngeal carcinoma 7 | 1,058

Tissue

Blood and immune system 109 | 16,909
Cardiovascular System 109 | 15,192
Digestive Tract 109 | 17,369
Endocrine System 109 | 18,159
Female tissues 109 | 17,400
Liver and Pancreas 109 | 16,750
Male tissues 109 | 17,142
Nervous System 109 | 16,725
Respiratory system 109 | 16,393
Skin and soft tissues 109 | 17,230
Urinary Tract 109 | 16,678

Target Family

Non-IDG 67 | 12,091
Enzyme 38 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Nucleotide Excision Repair 110 | 110
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
DNA helicase INO80 INO80 Tbio Enzyme -2.54124 327.2 47
Chromodomain-helicase-DNA-binding protein 1-like CHD1L Tbio Enzyme -2.22453 176.8 129
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Pre-mRNA-processing factor 19 PRPF19 Tbio Non-IDG -1.71524 54.2 234
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.36546 21.0 185
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.80737 619.7 475
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.40857 30.7 98