Development Level

Tbio 32 | 10,625
Tdark 17 | 7,003
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal retina morphology 2 | 100
decreased total body fat amoun... 2 | 186
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating bilirubi... 1 | 16
increased sacral vertebrae num... 1 | 62
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82

Disease

psoriasis 26 | 6,685
Breast cancer 23 | 3,094
ovarian cancer 23 | 8,484
lung cancer 21 | 4,466
non-small cell lung cancer 20 | 2,798
glioblastoma 19 | 5,572
invasive ductal carcinoma 19 | 2,950
medulloblastoma, large-cell 19 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
lung adenocarcinoma 18 | 2,713
ductal carcinoma in situ 17 | 1,745
osteosarcoma 16 | 7,933
group 3 medulloblastoma 15 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
primitive neuroectodermal tumor 15 | 3,031
adrenocortical carcinoma 14 | 1,427
pediatric high grade glioma 14 | 2,712
atypical teratoid / rhabdoid tumor 12 | 4,369
malignant mesothelioma 12 | 3,162
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
Endometriosis 9 | 535
Multiple myeloma 9 | 1,327
pancreatic cancer 9 | 2,300
posterior fossa group A ependymoma 9 | 1,511
nasopharyngeal carcinoma 8 | 1,056
sonic hedgehog group medulloblastoma 8 | 1,482
atypical teratoid/rhabdoid tumor 7 | 1,095
pituitary cancer 7 | 1,972
Cancer 6 | 2,346
IGA Glomerulonephritis 6 | 454
Waldenstrons macroglobulinemia 6 | 765
cystic fibrosis 6 | 1,665
cutaneous lupus erythematosus 5 | 1,056
non-small cell lung carcinoma 5 | 413
Atopic dermatitis 4 | 944
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Pick disease 3 | 1,893
acute myeloid leukemia 3 | 780
group 4 medulloblastoma 3 | 1,875
lung carcinoma 3 | 2,844
oligodendroglioma 3 | 2,849
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Acquired metabolic disease 2 | 267
CREST syndrome 2 | 10
Down syndrome 2 | 548
Retinoblastoma 2 | 14
Rheumatoid Arthritis 2 | 1,160
Seckel syndrome 2 | 34
Systemic scleroderma 2 | 66
Thyroiditis 2 | 25
Type 1 diabetes mellitus 2 | 101
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
aldosterone-producing adenoma 2 | 664
diabetes mellitus 2 | 1,663
gastric cancer 2 | 430
hepatocellular carcinoma 2 | 532
pancreatic carcinoma 2 | 567
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
Amyotrophic Lateral Sclerosis 1 | 431
Ankylosing spondylitis 1 | 138
Bipolar Disorder 1 | 266
Brachydactyly 1 | 52
Chronic Lymphocytic Leukemia 1 | 242
Cleft Lip 1 | 91
Diabetes Mellitus, Insulin-Dependent 1 | 76
Fanconi's anemia 1 | 50
Gastric antral vascular ectasia 1 | 11
Hypoglycemia 1 | 81
Influenza 1 | 142
Malaria 1 | 140
Male infertility 1 | 170
Muscle Weakness 1 | 92
Nijmegen breakage syndrome 1 | 23
Omphalocele 1 | 22
Squamous cell carcinoma of esophagus 1 | 82
Stomach Neoplasms 1 | 282
Telangiectasis 1 | 20
Testicular cancer 1 | 24
Vaccinia 1 | 37
astrocytoma 1 | 1,493
cystic fibrosis and chronic rhinosinusitis 1 | 213
dermatomyositis 1 | 933
glioblastoma multiforme 1 | 347
inflammatory breast cancer 1 | 404
mucosa-associated lymphoid tissue lymphoma 1 | 480
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686

Tissue

Female tissues 50 | 18,647
Male tissues 50 | 17,969
Blood and immune system 49 | 17,995
Cardiovascular System 49 | 17,958
Digestive Tract 49 | 18,473
Endocrine System 49 | 18,512
Nervous System 49 | 18,561
Urinary Tract 49 | 18,444
Liver and Pancreas 48 | 18,136
Respiratory system 48 | 17,484
Skin and soft tissues 42 | 18,115

Target Family

Non-IDG 49 | 11,971
Epigenetic 1 | 242

Reactome Pathway

Nucleosome assembly 50 | 50
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.68837 532.8 347
Protein Mis18-alpha MIS18A Tdark Non-IDG -2.10690 101.0 41
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Remodeling and spacing factor 1 RSF1 Tbio Epigenetic -1.64158 49.2 57
Holliday junction recognition protein HJURP Tbio Non-IDG -1.37643 22.0 78
Histone H2A.V H2AFV Tdark Non-IDG -1.20240 14.0 30
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.36 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.48218 30.2 48
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.12825 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20