Development Level

Tbio 32 | 10,625
Tdark 17 | 7,003
Tchem 1 | 1,890

IMPC Phenotype

preweaning lethality, complete... 4 | 633
abnormal retina morphology 2 | 100
decreased total body fat amoun... 2 | 186
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating bilirubi... 1 | 16
increased sacral vertebrae num... 1 | 62
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82

Disease

psoriasis 26 | 6,685
Breast cancer 23 | 3,098
ovarian cancer 23 | 8,491
lung cancer 21 | 4,473
non-small cell lung cancer 20 | 2,798
glioblastoma 19 | 5,572
invasive ductal carcinoma 19 | 2,950
medulloblastoma, large-cell 19 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
lung adenocarcinoma 18 | 2,714
ductal carcinoma in situ 17 | 1,745
osteosarcoma 16 | 7,933
group 3 medulloblastoma 15 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
primitive neuroectodermal tumor 15 | 3,031
adrenocortical carcinoma 14 | 1,427
pediatric high grade glioma 14 | 2,712
atypical teratoid / rhabdoid tumor 12 | 4,369
malignant mesothelioma 12 | 3,163
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
Endometriosis 9 | 535
Multiple myeloma 9 | 1,327
pancreatic cancer 9 | 2,300
posterior fossa group A ependymoma 9 | 1,511
nasopharyngeal carcinoma 8 | 1,056
sonic hedgehog group medulloblastoma 8 | 1,482
atypical teratoid/rhabdoid tumor 7 | 1,095
pituitary cancer 7 | 1,972
Cancer 6 | 2,346
IGA Glomerulonephritis 6 | 454
Waldenstrons macroglobulinemia 6 | 764
cystic fibrosis 6 | 1,670
cutaneous lupus erythematosus 5 | 1,056
non-small cell lung carcinoma 5 | 413
Atopic dermatitis 4 | 944
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Pick disease 3 | 1,893
acute myeloid leukemia 3 | 785
group 4 medulloblastoma 3 | 1,875
lung carcinoma 3 | 2,844
oligodendroglioma 3 | 2,849
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Acquired metabolic disease 2 | 267
CREST syndrome 2 | 10
Down syndrome 2 | 548
Retinoblastoma 2 | 14
Rheumatoid Arthritis 2 | 1,170
Seckel syndrome 2 | 35
Systemic scleroderma 2 | 66
Thyroiditis 2 | 25
Type 1 diabetes mellitus 2 | 104
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
aldosterone-producing adenoma 2 | 664
diabetes mellitus 2 | 1,663
gastric cancer 2 | 436
hepatocellular carcinoma 2 | 550
pancreatic carcinoma 2 | 567
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 788
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
Amyotrophic Lateral Sclerosis 1 | 432
Ankylosing spondylitis 1 | 138
Bipolar Disorder 1 | 266
Brachydactyly 1 | 52
Cleft Lip 1 | 91
Diabetes Mellitus, Insulin-Dependent 1 | 77
Fanconi's anemia 1 | 50
Gastric antral vascular ectasia 1 | 11
Hypoglycemia 1 | 81
Influenza 1 | 142
Malaria 1 | 140
Male infertility 1 | 170
Muscle Weakness 1 | 92
Neoplasm Recurrence, Local 1 | 23
Nijmegen breakage syndrome 1 | 23
Omphalocele 1 | 22
Squamous cell carcinoma of esophagus 1 | 82
Stomach Neoplasms 1 | 282
Telangiectasis 1 | 20
Testicular cancer 1 | 24
Vaccinia 1 | 37
astrocytoma 1 | 1,493
cystic fibrosis and chronic rhinosinusitis 1 | 213
dermatomyositis 1 | 966
glioblastoma multiforme 1 | 347
inflammatory breast cancer 1 | 404
mucosa-associated lymphoid tissue lymphoma 1 | 480
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686

Tissue

Female tissues 50 | 18,646
Male tissues 50 | 17,968
Blood and immune system 49 | 17,994
Cardiovascular System 49 | 17,957
Digestive Tract 49 | 18,472
Endocrine System 49 | 18,511
Nervous System 49 | 18,560
Urinary Tract 49 | 18,443
Liver and Pancreas 48 | 18,135
Respiratory system 48 | 17,483
Skin and soft tissues 42 | 18,114

Target Family

Non-IDG 49 | 11,969
Epigenetic 1 | 242

Reactome Pathway

Nucleosome assembly 50 | 50
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Protein Mis18-beta OIP5 Tbio Non-IDG -1.17135 15.6 42
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Mis18-binding protein 1 MIS18BP1 Tdark Non-IDG -1.04986 10.4 42
Protein Mis18-alpha MIS18A Tdark Non-IDG -2.12214 101.0 41
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.68453 51.8 276
Remodeling and spacing factor 1 RSF1 Tbio Epigenetic -1.65153 49.2 57