Development Level

Tbio 16 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
increased circulating magnesiu... 1 | 10
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
small superior vagus ganglion 1 | 74
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 16 | 11,493
medulloblastoma, large-cell 14 | 6,241
osteosarcoma 14 | 7,950
Cancer 13 | 2,499
Alzheimer's disease 11 | 658
Breast cancer 11 | 3,578
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
ovarian cancer 11 | 8,520
Schizophrenia 10 | 1,160
atypical teratoid / rhabdoid tumor 10 | 5,112
lung cancer 10 | 4,740
psoriasis 10 | 6,694
interstitial cystitis 9 | 2,312
pituitary cancer 9 | 1,972
Breast Neoplasms 8 | 445
malignant mesothelioma 8 | 3,232
Bipolar Disorder 7 | 666
Mammary Neoplasms 7 | 425
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Depressive disorder 6 | 409
adult high grade glioma 6 | 3,801
diabetes mellitus 6 | 1,728
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Disease Models, Animal 5 | 155
Endometriosis 5 | 540
Kidney cancer 5 | 2,613
Mental Depression 5 | 333
colon cancer 5 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
Alzheimer Disease 4 | 83
Amyotrophic lateral sclerosis 4 | 451
Animal Mammary Neoplasms 4 | 136
Atopic dermatitis 4 | 952
Cerebrovascular disease 4 | 238
Dementia 4 | 175
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
mucosa-associated lymphoid tissue lymphoma 4 | 484
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Acne 3 | 52
Acquired immunodeficiency syndrome 3 | 197
Adenocarcinoma 3 | 122
Arthritis, Juvenile 3 | 126
Asphyxia neonatorum 3 | 11
Autosomal recessive predisposition 3 | 1,442
Down syndrome 3 | 499
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Heart failure 3 | 162
Hidradenitis suppurativa 3 | 13
Hidradenitis suppurativa, familial 3 | 3
Juvenile arthritis 3 | 126
Lung Neoplasms 3 | 232
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Muscle Spasticity 3 | 195
Myocardial Infarction 3 | 151
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Neuroblastoma 3 | 80
Osteoporosis 3 | 363
Polycystic ovary syndrome 3 | 360
Recurrence 3 | 33
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Toxic encephalopathy 3 | 141
fibroadenoma 3 | 559
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
Atrophic vaginitis 2 | 14
Carcinoma, Hepatocellular 2 | 228
Cardiomyopathy, Dilated 2 | 83
Contraception 2 | 15
Liver carcinoma 2 | 240
Liver neoplasms 2 | 130
Major Depressive Disorder 2 | 301
Menopausal flushing 2 | 17
Parkinson's disease 2 | 392
Postmenopausal osteoporosis 2 | 19
Stomach Neoplasms 2 | 300
Unipolar Depression 2 | 250

Tissue

Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Skin and soft tissues 25 | 17,230
Blood and immune system 24 | 16,909
Liver and Pancreas 24 | 16,750
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 12 | 12,091
Enzyme 8 | 4,145
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Kinase 1 | 634

Reactome Pathway

Nuclear signaling by ERBB4 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098
Stromal cell-derived factor 1 CXCL12 Tbio Non-IDG -3.48446 3085.9 607
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Protein S100-B S100B Tchem Non-IDG -3.48893 3193.2 903
Pro-neuregulin-3, membrane-bound isoform NRG3 Tbio Non-IDG -1.56404 39.4 165
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610