Development Level

Tbio 10 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal retina morphology 1 | 71
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased cardiac muscle contr... 1 | 8
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101

Disease

Carcinoma 9 | 11,493
osteosarcoma 7 | 7,950
Emery-Dreifuss muscular dystrophy 6 | 23
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
Rheumatoid arthritis 5 | 1,191
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
Breast cancer 4 | 3,578
Cancer 4 | 2,499
Cardiomyopathy 4 | 116
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Progeria 4 | 25
Progressive disorder 4 | 142
astrocytic glioma 4 | 2,597
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Contracture 3 | 96
Contracture of joint 3 | 93
Dilated cardiomyopathy 3 | 56
Failure to gain weight 3 | 365
Flexion contracture 3 | 93
Flexion contractures of joints 3 | 93
Intellectual disability 3 | 1,016
Joint stiffness 3 | 84
Lipodystrophy 3 | 40
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Orbital separation excessive 3 | 244
Pediatric failure to thrive 3 | 365
Short stature 3 | 531
Vaccinia 3 | 36
Waldenstrons macroglobulinemia 3 | 765
group 3 medulloblastoma 3 | 4,104
lung adenocarcinoma 3 | 2,716
oligodendroglioma 3 | 2,850
Acrodermatitis enteropathica 2 | 18
Adenocarcinoma of lung 2 | 142
Astrocytoma, Pilocytic 2 | 3,081
Atherosclerosis 2 | 291
Atrioventricular block 2 | 35
Cardiomyopathy, Dilated 2 | 83
Chromosome 2p16.1-p15 deletion syndrome 2 | 8
Creatine phosphokinase serum increased 2 | 110
Decreased projection of midface 2 | 105
Degenerative polyarthritis 2 | 115
Elevated creatine kinase 2 | 110
Endometriosis 2 | 540
Epilepsy 2 | 792
Exophthalmos 2 | 112
Flexion contracture - elbow 2 | 32
Hyperreflexia 2 | 209
Hypotrophic malar bone 2 | 129
Hypotrophic midface 2 | 105
Inadequate arch length for tooth size 2 | 45
Malar flattening 2 | 129
Midface retrusion 2 | 105
Muscular Dystrophy, Emery-Dreifuss 2 | 5
Muscular atrophy 2 | 71
Muscular dystrophy 2 | 75
Myasthenia gravis 2 | 23
Myocardial Ischemia 2 | 169
Neurodegenerative disease 2 | 414
Oligospermia 2 | 36
Osteoporosis 2 | 363
Pectus excavatum 2 | 100
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Right bundle branch block 2 | 17
Slow progression 2 | 89
Small midface 2 | 105
Sparse eyebrow 2 | 42
Sparse eyelashes 2 | 31
Sudden Cardiac Death 2 | 29
Tooth Crowding 2 | 45
Tooth mass arch size discrepancy 2 | 45
Tooth size discrepancy 2 | 45
Tremor 2 | 113
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
adult-onset autosomal dominant demyelinating leukodystrophy 2 | 10
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
invasive ductal carcinoma 2 | 2,951
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
sarcoidosis 2 | 370
tuberculosis 2 | 2,010

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

Reactome Pathway

Nuclear Envelope Reassembly 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.28897 20.5 123
Inner nuclear membrane protein Man1 LEMD3 Tbio Non-IDG -2.30311 196.6 73
Emerin EMD Tbio Non-IDG -2.80459 640.6 299
LEM domain-containing protein 2 LEMD2 Tdark Non-IDG -0.53782 3.95 95
Lamin-B1 LMNB1 Tbio Non-IDG -2.58749 373.5 496
Barrier-to-autointegration factor BANF1 Tbio Non-IDG -2.89008 741.4 207
Lamina-associated polypeptide 2, isoforms beta/gamma TMPO Tbio Non-IDG -2.11834 246.0 283
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.32606 14.4 130