Development Level

Tbio 40 | 11,445
Tchem 5 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
corneal opacity 1 | 32
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
preweaning lethality, incomple... 1 | 499
thrombocytosis 1 | 27

Disease

Carcinoma 32 | 11,493
ovarian cancer 26 | 8,520
osteosarcoma 22 | 7,950
Cancer 21 | 2,499
lung cancer 18 | 4,740
psoriasis 16 | 6,694
Breast cancer 15 | 3,578
glioblastoma 13 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
breast carcinoma 12 | 1,638
group 3 medulloblastoma 11 | 4,104
medulloblastoma, large-cell 11 | 6,241
Ataxia telangiectasia 10 | 34
Nijmegen breakage syndrome 10 | 24
atypical teratoid / rhabdoid tumor 10 | 5,112
non-small cell lung cancer 10 | 2,890
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
Kidney cancer 8 | 2,613
Multiple myeloma 8 | 1,332
ductal carcinoma in situ 8 | 1,745
Intellectual disability 7 | 1,016
Pick disease 7 | 1,894
Severe combined immunodeficiency 7 | 51
colon cancer 7 | 1,478
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Microcephaly 6 | 166
Short stature 6 | 531
Small head 6 | 374
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,597
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
Autosomal recessive predisposition 5 | 1,442
Chromosome Breakage 5 | 36
DNA ligase IV deficiency 5 | 7
Dull intelligence 5 | 645
Hereditary Breast and Ovarian Cancer Syndrome 5 | 14
Hypoplastic mandible condyle 5 | 275
Low intelligence 5 | 645
Mandibular hypoplasia 5 | 275
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Poor school performance 5 | 645
Schizophrenia 5 | 1,160
Werner syndrome 5 | 29
adult high grade glioma 5 | 3,801
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
Astrocytoma, Pilocytic 4 | 3,081
Cleft Palate 4 | 271
Cognitive delay 4 | 608
Fanconi anemia 4 | 56
Fetal Growth Retardation 4 | 189
Global developmental delay 4 | 608
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Mental and motor retardation 4 | 608
Xeroderma pigmentosum 4 | 43
adrenocortical carcinoma 4 | 1,428
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
nasopharyngeal carcinoma 4 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Adenocarcinoma of lung 3 | 142
Alzheimer's disease 3 | 658
Attention deficit hyperactivity disorder 3 | 278
Broad flat nasal bridge 3 | 236
Cleft Lip 3 | 141
Congenital Epicanthus 3 | 177
Convex nasal ridge 3 | 37
Cryptorchidism 3 | 296
Dilated ventricles (finding) 3 | 121
Disease Models, Animal 3 | 155
Increased chromosomal breakage 3 | 27
Low anterior hairline 3 | 30
Lymphoma 3 | 81
Nasal bridge wide 3 | 236
Neurodegenerative disease 3 | 414
Photosensitivity of skin 3 | 51
Prostatic Neoplasms 3 | 495
Sloping forehead 3 | 46
Upward slant of palpebral fissure 3 | 75
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Pediatric failure to thrive 2 | 365

Tissue

Endocrine System 48 | 18,159
Blood and immune system 47 | 16,909
Cardiovascular System 47 | 15,192
Digestive Tract 47 | 17,369
Female tissues 47 | 17,400
Liver and Pancreas 47 | 16,750
Male tissues 47 | 17,142
Nervous System 47 | 16,725
Respiratory system 47 | 16,393
Skin and soft tissues 47 | 17,230
Urinary Tract 47 | 16,678

Target Family

Non-IDG 34 | 12,091
Enzyme 9 | 4,145
Epigenetic 2 | 242
Kinase 1 | 634
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

Reactome Pathway

Nonhomologous End-Joining (NHE... 48 | 48
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.09041 139.4 210
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.38165 22.7 117
DNA ligase 4 LIG4 Tbio Enzyme -2.14909 140.9 204
Telomere-associated protein RIF1 RIF1 Tbio Non-IDG -0.03141 1.27 98
Histone H2B type F-S H2BFS Tbio Non-IDG -0.50219 4.04 68