Development Level

Tclin 12 | 602
Tchem 9 | 1,890
Tbio 4 | 10,625

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
decreased circulating bilirubi... 1 | 14
decreased eosinophil cell numb... 1 | 41
embryonic lethality prior to t... 1 | 187
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3

Disease

medulloblastoma, large-cell 17 | 6,234
ovarian cancer 13 | 8,484
Chronic heart failure 12 | 46
atypical teratoid / rhabdoid tumor 12 | 4,369
glioblastoma 12 | 5,572
lung cancer 11 | 4,466
oligodendroglioma 11 | 2,849
colon cancer 10 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
lung carcinoma 10 | 2,844
Atrial Fibrillation 9 | 110
Breast cancer 9 | 3,094
astrocytic glioma 9 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,162
osteosarcoma 9 | 7,933
pediatric high grade glioma 9 | 2,712
pilocytic astrocytoma 9 | 3,086
primitive neuroectodermal tumor 9 | 3,031
Carcinoma 8 | 2,147
Impotence 8 | 45
Myocardial Perfusion Imaging Adjunct 8 | 25
Pick disease 8 | 1,893
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
Pulmonary hypertension 8 | 52
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
invasive ductal carcinoma 8 | 2,950
lung adenocarcinoma 8 | 2,713
psoriasis 8 | 6,685
ulcerative colitis 8 | 2,087
breast carcinoma 7 | 1,614
group 4 medulloblastoma 7 | 1,875
interstitial cystitis 7 | 2,299
ependymoma 6 | 2,514
pituitary cancer 6 | 1,972
posterior fossa group B ependymoma 6 | 1,530
Decompensated cardiac failure 5 | 9
adult high grade glioma 5 | 2,148
diabetes mellitus 5 | 1,663
non-small cell lung cancer 5 | 2,798
Angina Pectoris Prevention 4 | 4
Angina pectoris 4 | 21
Controlled Hypotension 4 | 6
Hypertension 4 | 287
Hypertensive disease 4 | 193
Hypertensive disorder 4 | 58
Hypertensive urgency 4 | 10
Left ventricular cardiac dysfunction 4 | 9
Malignant essential hypertension 4 | 5
Mammary Neoplasms 4 | 410
Obesity 4 | 616
Perioperative hypertension 4 | 5
Persistent pulmonary hypertension of the newborn 4 | 8
Rheumatoid Arthritis 4 | 1,160
cystic fibrosis 4 | 1,665
gastric carcinoma 4 | 832
medulloblastoma 4 | 1,524
pancreatic cancer 4 | 2,300
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 1,557
Asthma 3 | 349
Blood pressure finding 3 | 56
Brain Ischemia 3 | 87
Coronary artery disease 3 | 240
Essential Hypertension 3 | 82
Kidney disease 3 | 396
Multiple Sclerosis 3 | 498
Myocardial Infarction 3 | 126
Status Epilepticus 3 | 85
Systemic arterial pressure 3 | 56
acute myeloid leukemia 3 | 780
atypical teratoid/rhabdoid tumor 3 | 1,095
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
Amphetamine-Related Disorders 2 | 74
Atherosclerosis 2 | 275
Autistic Disorder 2 | 320
Cancer 2 | 2,346
Cerebrovascular disease 2 | 231
Colonic Neoplasms 2 | 126
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Heart disease 2 | 279
Lung disease 2 | 132
Male infertility 2 | 170
Neurodegenerative disease 2 | 383
Peripheral vascular disease 2 | 90
Reperfusion Injury 2 | 84
Seizures 2 | 95
astrocytoma 2 | 1,493
chronic rhinosinusitis 2 | 512
fibroadenoma 2 | 557
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
progressive supranuclear palsy 2 | 674
pulmonary arterial hypertension 2 | 36
spina bifida 2 | 1,064

Tissue

Blood and immune system 24 | 17,995
Cardiovascular System 24 | 17,958
Digestive Tract 24 | 18,473
Endocrine System 24 | 18,512
Female tissues 24 | 18,647
Liver and Pancreas 24 | 18,136
Male tissues 24 | 17,969
Nervous System 24 | 18,561
Respiratory system 24 | 17,484
Skin and soft tissues 24 | 18,115
Urinary Tract 24 | 18,444

Target Family

Enzyme 16 | 4,146
Ion Channel 6 | 341
Kinase 2 | 634
Non-IDG 1 | 11,971

Reactome Pathway

Nitric oxide stimulates guanyl... 25 | 25
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.32560 2206.3 649
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A Tchem Enzyme -1.87754 73.1 142
Protein MRVI1 MRVI1 Tbio Non-IDG -1.38594 25.6 21
Calcium-activated potassium channel subunit beta-4 KCNMB4 Tbio Ion Channel -0.82723 6.57 115
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A Tchem Enzyme -1.51667 37.2 195
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.06072 1170.6 213
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.64884 418.8 220
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.24811 18.1 146
Calcium-activated potassium channel subunit beta-2 KCNMB2 Tbio Ion Channel 1.28 0.09 174