Development Level

Tclin 12 | 602
Tchem 9 | 1,890
Tbio 4 | 10,625

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102

IMPC Phenotype

abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
decreased circulating bilirubi... 1 | 14
decreased eosinophil cell numb... 1 | 41
embryonic lethality prior to t... 1 | 187
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3

Disease

medulloblastoma, large-cell 17 | 6,234
ovarian cancer 13 | 8,491
Chronic heart failure 12 | 46
atypical teratoid / rhabdoid tumor 12 | 4,369
glioblastoma 12 | 5,572
lung cancer 11 | 4,473
oligodendroglioma 11 | 2,849
colon cancer 10 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
lung carcinoma 10 | 2,844
Atrial Fibrillation 9 | 110
Breast cancer 9 | 3,098
astrocytic glioma 9 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,163
osteosarcoma 9 | 7,933
pediatric high grade glioma 9 | 2,712
pilocytic astrocytoma 9 | 3,086
primitive neuroectodermal tumor 9 | 3,031
Carcinoma 8 | 2,147
Impotence 8 | 45
Myocardial Perfusion Imaging Adjunct 8 | 25
Pick disease 8 | 1,893
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
Pulmonary hypertension 8 | 52
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
invasive ductal carcinoma 8 | 2,950
lung adenocarcinoma 8 | 2,714
psoriasis 8 | 6,685
ulcerative colitis 8 | 2,087
breast carcinoma 7 | 1,614
group 4 medulloblastoma 7 | 1,875
interstitial cystitis 7 | 2,299
ependymoma 6 | 2,514
pituitary cancer 6 | 1,972
posterior fossa group B ependymoma 6 | 1,530
Decompensated cardiac failure 5 | 9
Hypertension 5 | 293
adult high grade glioma 5 | 2,148
diabetes mellitus 5 | 1,663
non-small cell lung cancer 5 | 2,798
Angina Pectoris Prevention 4 | 4
Angina pectoris 4 | 21
Controlled Hypotension 4 | 6
Hypertensive disease 4 | 193
Hypertensive disorder 4 | 58
Hypertensive urgency 4 | 10
Left ventricular cardiac dysfunction 4 | 9
Malignant essential hypertension 4 | 5
Mammary Neoplasms 4 | 410
Obesity 4 | 616
Perioperative hypertension 4 | 5
Persistent pulmonary hypertension of the newborn 4 | 8
Rheumatoid Arthritis 4 | 1,170
cystic fibrosis 4 | 1,670
gastric carcinoma 4 | 832
medulloblastoma 4 | 1,524
pancreatic cancer 4 | 2,300
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 1,563
Asthma 3 | 349
Blood pressure finding 3 | 56
Brain Ischemia 3 | 87
Coronary artery disease 3 | 240
Essential Hypertension 3 | 82
Kidney disease 3 | 397
Multiple Sclerosis 3 | 498
Myocardial Infarction 3 | 126
Status Epilepticus 3 | 85
Systemic arterial pressure 3 | 56
acute myeloid leukemia 3 | 785
atypical teratoid/rhabdoid tumor 3 | 1,095
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
Amphetamine-Related Disorders 2 | 74
Atherosclerosis 2 | 275
Autistic Disorder 2 | 320
Cancer 2 | 2,346
Cerebrovascular disease 2 | 231
Colonic Neoplasms 2 | 126
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Heart disease 2 | 279
Lung disease 2 | 136
Male infertility 2 | 170
Neurodegenerative disease 2 | 383
Peripheral vascular disease 2 | 90
Reperfusion Injury 2 | 84
Seizures 2 | 95
astrocytoma 2 | 1,493
chronic rhinosinusitis 2 | 512
fibroadenoma 2 | 557
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
progressive supranuclear palsy 2 | 674
pulmonary arterial hypertension 2 | 36
spina bifida 2 | 1,064

Tissue

Blood and immune system 24 | 17,994
Cardiovascular System 24 | 17,957
Digestive Tract 24 | 18,472
Endocrine System 24 | 18,511
Female tissues 24 | 18,646
Liver and Pancreas 24 | 18,135
Male tissues 24 | 17,968
Nervous System 24 | 18,560
Respiratory system 24 | 17,483
Skin and soft tissues 24 | 18,114
Urinary Tract 24 | 18,443

Target Family

Enzyme 16 | 4,146
Ion Channel 6 | 341
Kinase 2 | 634
Non-IDG 1 | 11,969

Reactome Pathway

Nitric oxide stimulates guanyl... 25 | 25
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.67695 418.8 220
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.08349 1170.6 213
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B Tclin Enzyme -1.36104 17.3 213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A Tclin Enzyme -2.06130 124.3 162
Guanylate cyclase soluble subunit beta-2 GUCY1B2 Tclin Enzyme 0.00000 0
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.34028 2206.3 649
Guanylate cyclase soluble subunit alpha-2 GUCY1A2 Tclin Enzyme -1.39098 23.4 87
cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A Tclin Enzyme -1.78439 58.1 158
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A Tchem Enzyme -1.88416 73.1 142
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.33050 2169.0 108