Development Level

Tbio 20 | 11,651
Tchem 6 | 1,388
Tclin 2 | 612
Tdark 2 | 6,593

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
decreased body length 1 | 101
decreased coping response 1 | 8
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
female infertility 1 | 60
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 21 | 8,520
Carcinoma 18 | 11,493
osteosarcoma 16 | 7,950
psoriasis 13 | 6,694
cystic fibrosis 10 | 1,696
ependymoma 10 | 4,679
glioblastoma 10 | 5,792
lung carcinoma 10 | 2,843
pancreatic cancer 10 | 2,398
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
medulloblastoma, large-cell 9 | 6,241
lung cancer 8 | 4,740
Breast cancer 7 | 3,578
Cancer 7 | 2,499
atypical teratoid / rhabdoid tumor 7 | 5,112
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
malignant mesothelioma 6 | 3,232
adult high grade glioma 5 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung cancer 5 | 2,890
primary pancreatic ductal adenocarcinoma 5 | 1,109
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Hypertension 4 | 396
Pick disease 4 | 1,894
adrenocortical carcinoma 4 | 1,428
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 807
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
primary Sjogren syndrome 4 | 735
primitive neuroectodermal tumor 4 | 3,035
Arthritis 3 | 290
Chronic Lymphocytic Leukemia 3 | 262
Colonic Neoplasms 3 | 142
Diphtheria 3 | 40
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Pellagra 3 | 26
Stomach Neoplasms 3 | 300
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676
Albuminuria 2 | 21
Amyotrophic lateral sclerosis 2 | 451
Arts syndrome 2 | 26
Atherosclerosis 2 | 291
Barrett's esophagus 2 | 182
Bipolar Disorder 2 | 666
Carcinoma, squamous cell of head and neck 2 | 31
Chemical and Drug Induced Liver Injury 2 | 195
Colitis 2 | 54
Colorectal Neoplasms 2 | 243
Duchenne muscular dystrophy 2 | 601
Endometriosis 2 | 540
Essential Hypertension 2 | 94
Heart disease 2 | 306
Hyperuricemia 2 | 47
Kidney disease 2 | 430
Macular degeneration 2 | 65
Malignant tumor of ovary 2 | 25
Melanoma 2 | 711
Mouth Neoplasms 2 | 55
Multiple myeloma 2 | 1,332
Obesity 2 | 678
Patent ductus arteriosus 2 | 90
Polycystic ovary syndrome 2 | 360
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
axial spondyloarthropathy 2 | 28
group 4 medulloblastoma 2 | 1,855
head and neck cancer 2 | 271
hepatocellular carcinoma 2 | 547
interstitial lung disease 2 | 298
non primary Sjogren syndrome sicca 2 | 891
periodontitis 2 | 293
urothelial carcinoma 2 | 318
Adrenal Gland Neoplasms 1 | 11
Skin Neoplasms 1 | 69

Tissue

Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Urinary Tract 30 | 16,678
Female tissues 29 | 17,400
Male tissues 29 | 17,142
Liver and Pancreas 28 | 16,750
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Blood and immune system 27 | 16,909
Cardiovascular System 27 | 15,192
Nervous System 26 | 16,725

Target Family

Enzyme 24 | 4,145
Kinase 4 | 634
Transporter 2 | 473

Reactome Pathway

Nicotinate metabolism 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.65191 40.5 121
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31765 20.1 141
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143
Nicotinate phosphoribosyltransferase NAPRT Tbio Enzyme -1.26235 18.2 103
ATP-dependent (S)-NAD(P)H-hydrate dehydratase NAXD Tdark Enzyme -0.36798 2.64 51
5'-nucleotidase NT5E Tchem Enzyme -2.88310 784.5 835
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Poly [ADP-ribose] polymerase 6 PARP6 Tchem Enzyme -0.64836 4.76 137
Poly [ADP-ribose] polymerase 9 PARP9 Tbio Enzyme -1.31595 19.3 72