Development Level

Tbio 8 | 11,445
Tchem 7 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

IMPC Phenotype

abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
decreased coping response 1 | 8
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydroencephaly 1 | 14
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 14 | 11,493
ovarian cancer 13 | 8,520
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
cystic fibrosis 6 | 1,696
ependymoma 6 | 4,679
pancreatic cancer 6 | 2,398
Breast cancer 5 | 3,578
Cancer 5 | 2,499
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
tuberculosis 5 | 2,010
Hypertension 4 | 396
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
gastric carcinoma 4 | 807
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Colonic Neoplasms 3 | 142
Diphtheria 3 | 40
Kidney cancer 3 | 2,613
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
medulloblastoma, large-cell 3 | 6,241
oligodendroglioma 3 | 2,850
primary pancreatic ductal adenocarcinoma 3 | 1,109
Amyotrophic lateral sclerosis 2 | 451
Arthritis 2 | 290
Arts syndrome 2 | 26
Atherosclerosis 2 | 291
Bipolar Disorder 2 | 666
Carcinoma, squamous cell of head and neck 2 | 31
Colitis 2 | 54
Colorectal Neoplasms 2 | 243
Essential Hypertension 2 | 94
Heart disease 2 | 306
Hyperuricemia 2 | 49
Kidney disease 2 | 430
Malignant tumor of ovary 2 | 25
Melanoma 2 | 711
Mouth Neoplasms 2 | 55
Obesity 2 | 678
Patent ductus arteriosus 2 | 90
Pellagra 2 | 26
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Stomach Neoplasms 2 | 300
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
head and neck cancer 2 | 271
hepatocellular carcinoma 2 | 547
interstitial lung disease 2 | 298
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
progressive supranuclear palsy 2 | 676
Actinic keratosis 1 | 21
Adenocarcinoma Of Esophagus 1 | 14
Adenomatous Polyposis Coli 1 | 16
Adrenal Gland Neoplasms 1 | 11
B-Cell Lymphomas 1 | 12
Barrett Esophagus 1 | 16
Carcinoma, Ductal, Breast 1 | 11
Duodenal ulcer 1 | 20
Edema 1 | 81
Esophagitis 1 | 35
Gastritis 1 | 47
Hyperglycemia 1 | 137
Inflammatory Bowel Diseases 1 | 35
Juvenile rheumatoid arthritis 1 | 111
Kidney Failure, Chronic 1 | 46
Leiomyosarcoma 1 | 24
Lymphoma, B-Cell 1 | 6
Marijuana Abuse 1 | 31
Menorrhagia 1 | 25
Pain 1 | 103
Papilloma 1 | 44
Skin Neoplasms 1 | 69
Synovitis 1 | 78
Type 1 diabetes mellitus 1 | 109

Tissue

Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Urinary Tract 18 | 16,678
Female tissues 17 | 17,400
Male tissues 17 | 17,142
Respiratory system 17 | 16,393
Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Liver and Pancreas 16 | 16,750
Nervous System 16 | 16,725
Skin and soft tissues 16 | 17,230

Target Family

Enzyme 16 | 4,145
Transporter 2 | 473

Reactome Pathway

Nicotinamide salvaging 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
NAD(P)H-hydrate epimerase NAXE Tbio Enzyme -1.23500 14.3 142
Nicotinamide N-methyltransferase NNMT Tchem Enzyme -2.09313 121.9 268
Poly [ADP-ribose] polymerase 6 PARP6 Tchem Enzyme -0.64836 4.76 137
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Poly [ADP-ribose] polymerase 10 PARP10 Tchem Enzyme -1.07289 14.2 67
Poly [ADP-ribose] polymerase 14 PARP14 Tbio Enzyme -1.51062 31.2 35
Poly [ADP-ribose] polymerase 9 PARP9 Tbio Enzyme -1.31595 19.3 72
Renalase RNLS Tbio Enzyme -2.13139 145.3 183
Prostacyclin synthase PTGIS Tchem Enzyme -2.55019 341.8 152