Development Level

Tbio 378 | 10,625
Tchem 119 | 1,890
Tdark 24 | 7,003
Tclin 21 | 602

Collection

Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 9 | 260
abnormal lens morphology 6 | 73
decreased circulating insulin ... 5 | 75
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
increased circulating alkaline... 5 | 119
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased total body fat amoun... 4 | 186
increased bone mineral density 4 | 52
increased lean body mass 4 | 107
increased leukocyte cell numbe... 4 | 37
abnormal embryo size 3 | 112
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating serum al... 3 | 79
decreased circulating triglyce... 3 | 83
embryonic lethality prior to o... 3 | 148
enlarged lymph nodes 3 | 27
hyperactivity 3 | 108
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased circulating total pr... 3 | 20
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal bone structure 2 | 131
abnormal retinal vasculature m... 2 | 15
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating amylase ... 2 | 24
decreased circulating fructosa... 2 | 31
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased threshold for audito... 2 | 32
edema 2 | 11
hydrops fetalis 2 | 22
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
increased spleen weight 2 | 3
increased total body fat amoun... 2 | 57
small adrenal glands 2 | 15
thrombocytosis 2 | 23
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased startle reflex 1 | 38
limb grasping 1 | 35
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
stereotypic behavior 1 | 3
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

osteosarcoma 292 | 7,933
ovarian cancer 287 | 8,484
psoriasis 252 | 6,685
lung cancer 196 | 4,466
Cancer 191 | 2,346
glioblastoma 184 | 5,572
medulloblastoma, large-cell 164 | 6,234
diabetes mellitus 145 | 1,663
lung carcinoma 142 | 2,844
non-small cell lung cancer 130 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 124 | 3,289
malignant mesothelioma 122 | 3,162
pilocytic astrocytoma 118 | 3,086
interstitial cystitis 117 | 2,299
lung adenocarcinoma 114 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,956
subependymal giant cell astrocytoma 112 | 2,287
ulcerative colitis 111 | 2,087
invasive ductal carcinoma 110 | 2,950
tuberculosis 110 | 1,557
atypical teratoid / rhabdoid tumor 107 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,988
pancreatic cancer 107 | 2,300
Breast cancer 101 | 3,094
pediatric high grade glioma 96 | 2,712
Rheumatoid Arthritis 95 | 1,160
astrocytoma 87 | 1,493
Arthritis 86 | 248
Multiple myeloma 86 | 1,327
mucosa-associated lymphoid tissue lymphoma 81 | 480
Waldenstrons macroglobulinemia 79 | 765
pancreatic ductal adenocarcinoma liver metastasis 77 | 1,795
Ankylosing spondylitis 75 | 138
cutaneous lupus erythematosus 74 | 1,056
Hypersensitivity reaction type II disease 72 | 235
primary pancreatic ductal adenocarcinoma 70 | 1,271
juvenile dermatomyositis 66 | 1,189
dermatomyositis 64 | 933
oligodendroglioma 64 | 2,849
posterior fossa group A ependymoma 62 | 1,511
Acquired immunodeficiency syndrome 61 | 164
acute quadriplegic myopathy 61 | 1,157
cystic fibrosis 60 | 1,665
primitive neuroectodermal tumor 60 | 3,031
Juvenile rheumatoid arthritis 59 | 104
Uveitis 59 | 103
Behcet's disease 56 | 74
breast carcinoma 56 | 1,614
group 4 medulloblastoma 56 | 1,875
ependymoma 55 | 2,514
Carcinoma 54 | 2,147
Kidney disease 52 | 396
colon cancer 52 | 1,475
Psoriatic arthritis 50 | 83
IGA Glomerulonephritis 49 | 454
Pick disease 49 | 1,893
ductal carcinoma in situ 49 | 1,745
esophageal adenocarcinoma 49 | 737
group 3 medulloblastoma 49 | 2,254
pituitary cancer 49 | 1,972
Duchenne muscular dystrophy 46 | 602
adult high grade glioma 46 | 2,148
adrenocortical carcinoma 44 | 1,427
primary Sjogren syndrome 44 | 789
gastric carcinoma 43 | 832
nasopharyngeal carcinoma 43 | 1,056
Atopic dermatitis 42 | 944
Multiple Sclerosis 41 | 498
Anemia 40 | 252
Stevens-Johnson syndrome 39 | 78
astrocytic glioma 38 | 2,241
Takayasu's arteritis 37 | 52
Alzheimer's disease 35 | 644
Congenital adrenal hyperplasia 35 | 74
Liver disease 35 | 219
Retinal vasculitis 35 | 36
active Crohn's disease 35 | 918
non primary Sjogren syndrome sicca 35 | 840
Asthma 33 | 349
atypical teratoid/rhabdoid tumor 33 | 1,095
medulloblastoma 33 | 1,524
periodontitis 33 | 269
Skin disease 32 | 65
spina bifida 31 | 1,064
Vascular disease 30 | 281
chronic lymphosyte leukemia 29 | 232
sonic hedgehog group medulloblastoma 28 | 1,482
acute myeloid leukemia 26 | 780
tuberculosis and treatment for 6 months 26 | 686
Hemochromatosis 25 | 55
Leprosy 25 | 77
Prostatic Neoplasms 25 | 471
pancreatic carcinoma 25 | 567
Atherosclerosis 24 | 275
Hepatitis B 24 | 103
Primary immunodeficiency disease 24 | 52
hepatocellular carcinoma 24 | 532
nephrosclerosis 24 | 329
Down syndrome 23 | 548
Neurodegenerative disease 23 | 383

Tissue

Blood and immune system 479 | 17,995
Digestive Tract 479 | 18,473
Liver and Pancreas 479 | 18,136
Nervous System 479 | 18,561
Endocrine System 478 | 18,512
Respiratory system 478 | 17,484
Male tissues 477 | 17,969
Urinary Tract 477 | 18,444
Cardiovascular System 476 | 17,958
Female tissues 476 | 18,647
Skin and soft tissues 468 | 18,115

Target Family

Non-IDG 316 | 11,971
Enzyme 181 | 4,146
Kinase 13 | 634
Transporter 12 | 473
GPCR 10 | 406
Ion Channel 8 | 341
Transcription Factor 2 | 1,400

Reactome Pathway

Neutrophil degranulation 542 | 542
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.17754 15.9 54
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0
Interleukin enhancer-binding factor 2 ILF2 Tbio Non-IDG -1.51960 36.4 249