Development Level

Tbio 378 | 10,625
Tchem 119 | 1,890
Tdark 24 | 7,003
Tclin 21 | 602

Collection

GPCR: IDG Consortium (Targets) 2 | 127
Ion Channel: IDG Consortium (Targets) 2 | 102
GPCR: IDG Consortium (Complete/Control) 1 | 26
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 9 | 260
abnormal lens morphology 6 | 73
decreased circulating insulin ... 5 | 75
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
increased circulating alkaline... 5 | 119
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased total body fat amoun... 4 | 186
increased bone mineral density 4 | 52
increased lean body mass 4 | 107
increased leukocyte cell numbe... 4 | 37
abnormal embryo size 3 | 112
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating serum al... 3 | 79
decreased circulating triglyce... 3 | 83
embryonic lethality prior to o... 3 | 148
enlarged lymph nodes 3 | 27
hyperactivity 3 | 108
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased circulating total pr... 3 | 20
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal bone structure 2 | 131
abnormal retinal vasculature m... 2 | 15
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating amylase ... 2 | 24
decreased circulating fructosa... 2 | 31
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased threshold for audito... 2 | 32
edema 2 | 11
hydrops fetalis 2 | 22
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
increased spleen weight 2 | 3
increased total body fat amoun... 2 | 57
small adrenal glands 2 | 15
thrombocytosis 2 | 23
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased startle reflex 1 | 38
limb grasping 1 | 35
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
stereotypic behavior 1 | 3
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

osteosarcoma 292 | 7,933
ovarian cancer 287 | 8,491
psoriasis 252 | 6,685
lung cancer 196 | 4,473
Cancer 191 | 2,346
glioblastoma 184 | 5,572
medulloblastoma, large-cell 164 | 6,234
diabetes mellitus 145 | 1,663
lung carcinoma 142 | 2,844
non-small cell lung cancer 130 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 124 | 3,289
malignant mesothelioma 122 | 3,163
pilocytic astrocytoma 118 | 3,086
interstitial cystitis 117 | 2,299
lung adenocarcinoma 114 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,956
subependymal giant cell astrocytoma 112 | 2,287
ulcerative colitis 111 | 2,087
invasive ductal carcinoma 110 | 2,950
tuberculosis 110 | 1,563
atypical teratoid / rhabdoid tumor 107 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,988
pancreatic cancer 107 | 2,300
Breast cancer 101 | 3,098
dermatomyositis 98 | 966
pediatric high grade glioma 96 | 2,712
Rheumatoid Arthritis 95 | 1,170
astrocytoma 87 | 1,493
Arthritis 86 | 248
Multiple myeloma 86 | 1,327
mucosa-associated lymphoid tissue lymphoma 81 | 480
Waldenstrons macroglobulinemia 79 | 764
pancreatic ductal adenocarcinoma liver metastasis 77 | 1,795
Ankylosing spondylitis 75 | 138
cutaneous lupus erythematosus 74 | 1,056
Hypersensitivity reaction type II disease 72 | 235
primary pancreatic ductal adenocarcinoma 70 | 1,271
juvenile dermatomyositis 66 | 1,189
oligodendroglioma 64 | 2,849
posterior fossa group A ependymoma 62 | 1,511
Acquired immunodeficiency syndrome 61 | 164
acute quadriplegic myopathy 61 | 1,157
cystic fibrosis 61 | 1,670
primitive neuroectodermal tumor 60 | 3,031
Juvenile rheumatoid arthritis 59 | 105
Uveitis 59 | 103
Behcet's disease 56 | 74
Human immunodeficiency virus infectious disease 56 | 129
breast carcinoma 56 | 1,614
group 4 medulloblastoma 56 | 1,875
ependymoma 55 | 2,514
Carcinoma 54 | 2,147
Kidney disease 52 | 397
Stevens-Johnson syndrome 52 | 91
colon cancer 52 | 1,475
Psoriatic arthritis 50 | 85
IGA Glomerulonephritis 49 | 454
Pick disease 49 | 1,893
ductal carcinoma in situ 49 | 1,745
esophageal adenocarcinoma 49 | 737
group 3 medulloblastoma 49 | 2,254
pituitary cancer 49 | 1,972
Dermatitis 47 | 141
Duchenne muscular dystrophy 46 | 602
adult high grade glioma 46 | 2,148
adrenocortical carcinoma 44 | 1,427
primary Sjogren syndrome 44 | 788
gastric carcinoma 43 | 832
nasopharyngeal carcinoma 43 | 1,056
Atopic dermatitis 42 | 944
Multiple Sclerosis 41 | 498
Anemia 40 | 252
Nephritis 38 | 63
Synovitis 38 | 72
astrocytic glioma 38 | 2,241
Takayasu's arteritis 37 | 54
Behcet's syndrome 36 | 50
Alzheimer's disease 35 | 644
Congenital adrenal hyperplasia 35 | 74
Liver disease 35 | 219
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
active Crohn's disease 35 | 918
drug-induced hepatitis 35 | 44
non primary Sjogren syndrome sicca 35 | 840
Asthma 33 | 349
atypical teratoid/rhabdoid tumor 33 | 1,095
medulloblastoma 33 | 1,524
periodontitis 33 | 269
Skin disease 32 | 65
spina bifida 31 | 1,064
Vascular disease 30 | 281
chronic lymphosyte leukemia 29 | 232
sonic hedgehog group medulloblastoma 28 | 1,482
acute myeloid leukemia 26 | 785
hepatocellular carcinoma 26 | 550
tuberculosis and treatment for 6 months 26 | 686
Leprosy 25 | 77
Prostatic Neoplasms 25 | 471
pancreatic carcinoma 25 | 567

Tissue

Blood and immune system 479 | 17,994
Digestive Tract 479 | 18,472
Liver and Pancreas 479 | 18,135
Nervous System 479 | 18,560
Endocrine System 478 | 18,511
Respiratory system 478 | 17,483
Male tissues 477 | 17,968
Urinary Tract 477 | 18,443
Cardiovascular System 476 | 17,957
Female tissues 476 | 18,646
Skin and soft tissues 468 | 18,114

Target Family

Non-IDG 316 | 11,969
Enzyme 181 | 4,146
Kinase 13 | 634
Transporter 12 | 473
GPCR 10 | 408
Ion Channel 8 | 341
Transcription Factor 2 | 1,400

Reactome Pathway

Neutrophil degranulation 542 | 542
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Complement receptor type 1 CR1 Tbio Non-IDG -3.34929 2279.9 502
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.24582 1740.5 143
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.54794 32.2 109
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.87358 1568.8 0
Alpha-1-antichymotrypsin SERPINA3 Tchem Non-IDG -2.94207 803.8 261
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Complement C3 C3 Tbio Non-IDG -3.54548 3337.1 965
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.50018 27956.4 30
Cystatin-C CST3 Tbio Non-IDG -3.48935 3020.7 756