Development Level

Tbio 61 | 11,445
Tclin 41 | 613
Tchem 39 | 1,598
Tdark 8 | 6,588

Collection

Ion Channel: IDG Consortium (T... 15 | 99
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 7 | 499
abnormal behavior 6 | 298
decreased body weight 6 | 161
decreased total body fat amoun... 6 | 207
hyperactivity 5 | 148
enlarged heart 4 | 210
tremors 4 | 39
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
increased bone mineral content 3 | 108
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased vertical activity 2 | 208
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal cecum morphology 1 | 7
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart shape 1 | 5
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
brachydactyly 1 | 19
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged seminal vesicle 1 | 10
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
limb grasping 1 | 41
male infertility 1 | 123
mydriasis 1 | 6
short tibia 1 | 97
small kidney 1 | 16
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 117 | 11,493
glioblastoma 88 | 5,792
medulloblastoma, large-cell 88 | 6,241
atypical teratoid / rhabdoid tumor 81 | 5,112
ependymoma 77 | 4,679
adult high grade glioma 68 | 3,801
psoriasis 67 | 6,694
primitive neuroectodermal tumor 66 | 3,035
group 3 medulloblastoma 60 | 4,104
osteosarcoma 59 | 7,950
oligodendroglioma 58 | 2,850
ovarian cancer 58 | 8,520
Astrocytoma, Pilocytic 57 | 3,081
Schizophrenia 56 | 1,160
astrocytic glioma 53 | 2,597
lung carcinoma 48 | 2,843
subependymal giant cell astrocytoma 46 | 2,287
Kidney cancer 42 | 2,613
Pick disease 42 | 1,894
Bipolar Disorder 39 | 666
Epilepsy 38 | 792
lung cancer 37 | 4,740
Breast cancer 33 | 3,578
Alcoholic Intoxication, Chronic 32 | 289
General anesthesia 27 | 53
Depressive disorder 26 | 409
malignant mesothelioma 25 | 3,232
Intellectual disability 24 | 1,016
pituitary cancer 24 | 1,972
Mental Depression 23 | 333
invasive ductal carcinoma 23 | 2,951
Autistic Disorder 22 | 364
Alcohol dependence 21 | 107
Tonic-clonic epilepsy 21 | 47
group 4 medulloblastoma 21 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Major Depressive Disorder 19 | 301
non-small cell lung cancer 19 | 2,890
pancreatic cancer 19 | 2,398
Local anesthesia 17 | 40
Seizures 17 | 596
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung adenocarcinoma 17 | 2,716
Autosomal recessive predisposition 16 | 1,442
Unipolar Depression 16 | 250
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
tuberculosis 16 | 2,010
Lennox-Gastaut syndrome 15 | 34
Nicotine dependence 15 | 54
Cancer 14 | 2,499
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Mood Disorders 14 | 184
Poor school performance 14 | 645
Simple partial seizure 14 | 26
astrocytoma 14 | 1,146
breast carcinoma 14 | 1,638
ulcerative colitis 14 | 1,819
Anxiety 13 | 136
Liver cancer 13 | 604
Melanoma 13 | 711
Parkinson's disease 13 | 392
Alcoholism 12 | 45
Epilepsy characterized by intractable complex partial seizures 12 | 28
Insomnia 12 | 20
Irritable bowel syndrome 12 | 60
Migraine Prevention 12 | 23
Muscle hypotonia 12 | 571
Substance Withdrawal Syndrome 12 | 55
active Crohn's disease 12 | 922
colon cancer 12 | 1,478
Cocaine-Related Disorders 11 | 92
Rheumatoid arthritis 11 | 1,191
Sedation as Adjunct to Anesthesia 11 | 15
Skin cancer 11 | 469
juvenile dermatomyositis 11 | 1,187
pediatric high grade glioma 11 | 1,064
Byzanthine arch palate 10 | 194
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Tetanus 10 | 68
Toxic encephalopathy 10 | 141
active ulcerative colitis 10 | 764
Alzheimer's disease 9 | 658
Cocaine Dependence 9 | 51
Low set ears 9 | 181
Orbital separation excessive 9 | 244
Status Epilepticus 9 | 98
gastric carcinoma 9 | 807
primary Sjogren syndrome 9 | 735
substance-related disorder 9 | 162
Down syndrome 8 | 499
Lung Neoplasms 8 | 232
Schizoaffective Disorder 8 | 55
diabetes mellitus 8 | 1,728

Tissue

Endocrine System 145 | 18,159
Nervous System 138 | 16,725
Digestive Tract 136 | 17,369
Blood and immune system 130 | 16,909
Female tissues 130 | 17,400
Skin and soft tissues 130 | 17,230
Male tissues 127 | 17,142
Liver and Pancreas 121 | 16,750
Urinary Tract 119 | 16,678
Respiratory system 115 | 16,393
Cardiovascular System 103 | 15,192

Target Family

Ion Channel 66 | 344
Non-IDG 42 | 12,091
Kinase 20 | 634
Enzyme 18 | 4,145
GPCR 2 | 408
Transcription Factor 1 | 1,400

Reactome Pathway

Neurotransmitter receptors and... 149 | 149
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Glutamate receptor-interacting protein 1 GRIP1 Tbio Non-IDG -2.18570 152.7 157
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 Tbio Ion Channel -1.74365 53.9 92