Development Level

Tbio 183 | 11,651
Tclin 108 | 612
Tchem 56 | 1,388
Tdark 20 | 6,593

Collection

RFA-RM-18-021 46 | 328
Ion Channel: IDG Consortium (T... 44 | 99
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

abnormal behavior 14 | 298
preweaning lethality, incomple... 13 | 499
decreased total body fat amoun... 11 | 207
hyperactivity 11 | 148
preweaning lethality, complete... 10 | 979
decreased body weight 7 | 161
decreased circulating choleste... 7 | 93
decreased circulating HDL chol... 6 | 68
increased circulating sodium l... 6 | 71
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
tremors 6 | 39
abnormal behavioral response t... 5 | 66
abnormal bone structure 5 | 187
decreased grip strength 5 | 116
enlarged heart 5 | 210
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased circulating chloride... 5 | 41
increased startle reflex 5 | 112
abnormal epididymis morphology 4 | 42
abnormal gait 4 | 69
abnormal locomotor behavior 4 | 24
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased fasted circulating g... 4 | 65
decreased vertical activity 4 | 208
increased total body fat amoun... 4 | 134
short tibia 4 | 97
abnormal bone mineralization 3 | 38
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
abnormal testis morphology 3 | 43
decreased circulating LDL chol... 3 | 38
decreased circulating alkaline... 3 | 46
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased pulmonary respirator... 3 | 5
embryonic lethality prior to t... 3 | 278
enlarged epididymis 3 | 31
small superior vagus ganglion 3 | 74
small testis 3 | 58
abnormal heart shape 2 | 5
abnormal lens morphology 2 | 81
abnormal response to tactile s... 2 | 17
abnormal retinal blood vessel ... 2 | 26
abnormal startle reflex 2 | 15
decreased body length 2 | 101
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased exploration in new e... 2 | 11
decreased hemoglobin content 2 | 68
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
enlarged seminal vesicle 2 | 10
enlarged stomach 2 | 2
hydrometra 2 | 53
improved glucose tolerance 2 | 79
increased circulating alanine ... 2 | 13
increased circulating amylase ... 2 | 25
increased circulating iron lev... 2 | 30
increased heart weight 2 | 62
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
increased vertical activity 2 | 24
limb grasping 2 | 41
small thymus 2 | 16
abnormal ear morphology 1 | 9
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 293 | 11,493
medulloblastoma, large-cell 210 | 6,241
glioblastoma 208 | 5,792
atypical teratoid / rhabdoid tumor 195 | 5,112
ependymoma 195 | 4,679
adult high grade glioma 176 | 3,801
group 3 medulloblastoma 155 | 4,104
psoriasis 155 | 6,694
ovarian cancer 149 | 8,520
primitive neuroectodermal tumor 147 | 3,035
Astrocytoma, Pilocytic 143 | 3,081
osteosarcoma 142 | 7,950
oligodendroglioma 134 | 2,850
astrocytic glioma 125 | 2,597
Schizophrenia 121 | 1,160
Kidney cancer 118 | 2,613
lung cancer 104 | 4,740
lung carcinoma 102 | 2,843
subependymal giant cell astrocytoma 101 | 2,287
Pick disease 86 | 1,894
Epilepsy 81 | 792
Bipolar Disorder 78 | 666
malignant mesothelioma 76 | 3,232
pituitary cancer 74 | 1,972
Breast cancer 70 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,955
Intellectual disability 54 | 1,016
Autistic Disorder 52 | 364
invasive ductal carcinoma 50 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,291
non-small cell lung cancer 49 | 2,890
interstitial cystitis 48 | 2,312
Alcoholic Intoxication, Chronic 47 | 289
Multiple Sclerosis 47 | 540
lung adenocarcinoma 47 | 2,716
Depressive disorder 45 | 409
Mental Depression 45 | 333
group 4 medulloblastoma 45 | 1,855
Seizures 41 | 596
Eaton-Lambert syndrome 40 | 40
colon cancer 40 | 1,478
pancreatic cancer 40 | 2,398
Liver cancer 36 | 604
Major Depressive Disorder 35 | 301
Parkinson's disease 35 | 392
Alzheimer's disease 34 | 658
ductal carcinoma in situ 34 | 1,745
General anesthesia 32 | 53
astrocytoma 32 | 1,146
Melanoma 31 | 711
cystic fibrosis 31 | 1,696
tuberculosis 31 | 2,010
Unipolar Depression 30 | 250
Alcohol dependence 29 | 107
Autosomal recessive predisposition 29 | 1,442
breast carcinoma 28 | 1,638
ulcerative colitis 28 | 1,819
Cancer 27 | 2,499
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
adrenocortical carcinoma 27 | 1,428
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Mood Disorders 26 | 184
Poor school performance 26 | 645
Amyotrophic lateral sclerosis 25 | 451
Muscle hypotonia 25 | 571
pediatric high grade glioma 25 | 1,064
Toxic encephalopathy 24 | 141
active Crohn's disease 23 | 922
Nicotine dependence 22 | 54
Tonic-clonic epilepsy 22 | 47
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Cocaine-Related Disorders 21 | 92
Obesity 21 | 678
Rheumatoid arthritis 21 | 1,191
Skin cancer 21 | 469
diabetes mellitus 21 | 1,728
gastric carcinoma 21 | 807
Attention deficit hyperactivity disorder 19 | 278
active ulcerative colitis 19 | 764
non primary Sjogren syndrome sicca 19 | 891
Cerebellar Ataxia 18 | 304
Down syndrome 18 | 499
Local anesthesia 18 | 40
medulloblastoma 18 | 720
Heart disease 17 | 306
juvenile dermatomyositis 17 | 1,187
primary pancreatic ductal adenocarcinoma 17 | 1,109
Acquired metabolic disease 16 | 336
Atrial Fibrillation 16 | 124
Status Epilepticus 16 | 98
aldosterone-producing adenoma 16 | 665
cutaneous lupus erythematosus 16 | 1,057
Vascular disease 15 | 319
acute quadriplegic myopathy 15 | 1,158

Tissue

Endocrine System 355 | 18,159
Nervous System 343 | 16,725
Digestive Tract 333 | 17,369
Female tissues 331 | 17,400
Skin and soft tissues 325 | 17,230
Male tissues 324 | 17,142
Liver and Pancreas 310 | 16,750
Urinary Tract 307 | 16,678
Blood and immune system 305 | 16,909
Respiratory system 292 | 16,393
Cardiovascular System 264 | 15,192

Target Family

Ion Channel 150 | 344
Non-IDG 126 | 12,091
Enzyme 42 | 4,145
Kinase 22 | 634
Transporter 22 | 473
GPCR 4 | 408
Transcription Factor 1 | 1,400

Reactome Pathway

Neuronal System 367 | 367
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Glutamate receptor-interacting protein 2 GRIP2 Tdark Non-IDG 0.00000 0
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Sodium-dependent serotonin transporter SLC6A4 Tclin Transporter -3.63283 4453.8 245
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Leucine-rich repeat and fibronectin type-III domain-containing protein 2 LRFN2 Tbio Non-IDG -0.81315 6.12 97
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
Leucine-rich repeat and fibronectin type-III domain-containing protein 3 LRFN3 Tdark Non-IDG -0.48565 2.89 63