Development Level

Tbio 134 | 10,625
Tclin 105 | 602
Tchem 81 | 1,890
Tdark 23 | 7,003

Collection

Eligible Ion Channel Proteins 49 | 117
Eligible Kinase Proteins 3 | 134

IMPC Term

abnormal behavior 11 | 226
preweaning lethality, incomple... 9 | 260
decreased circulating HDL chol... 8 | 77
decreased circulating choleste... 7 | 85
decreased total body fat amoun... 7 | 186
decreased body weight 6 | 174
decreased lean body mass 6 | 195
hyperactivity 6 | 108
abnormal bone structure 5 | 131
decreased grip strength 5 | 123
increased circulating alkaline... 5 | 119
increased circulating sodium l... 5 | 71
preweaning lethality, complete... 5 | 633
tremors 5 | 34
abnormal gait 4 | 51
decreased circulating serum al... 4 | 79
decreased fasted circulating g... 4 | 49
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
abnormal bone mineralization 3 | 55
abnormal epididymis morphology 3 | 31
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 37
decreased circulating alkaline... 3 | 41
decreased circulating fructosa... 3 | 31
decreased pulmonary respirator... 3 | 4
enlarged heart 3 | 111
impaired glucose tolerance 3 | 52
increased bone mineral content 3 | 92
increased circulating chloride... 3 | 43
increased grip strength 3 | 83
increased total body fat amoun... 3 | 57
straub tail 3 | 26
abnormal heart left ventricle ... 2 | 20
abnormal locomotor activation 2 | 26
abnormal response to tactile s... 2 | 16
abnormal retinal blood vessel ... 2 | 18
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
abnormal startle reflex 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating total pr... 2 | 41
decreased exploration in new e... 2 | 9
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
embryonic lethality prior to t... 2 | 187
enlarged epididymis 2 | 27
enlarged stomach 2 | 2
hypoactivity 2 | 89
increased circulating HDL chol... 2 | 63
increased circulating alanine ... 2 | 11
increased circulating iron lev... 2 | 25
increased vertical activity 2 | 18
lethargy 2 | 5
male infertility 2 | 62
short tibia 2 | 82
small thymus 2 | 11
abnormal behavioral response t... 1 | 52
abnormal ear morphology 1 | 5
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
enlarged spleen 1 | 26
increased CD4-positive, CD25-p... 1 | 18
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

medulloblastoma, large-cell 200 | 6,234
glioblastoma 189 | 5,572
atypical teratoid / rhabdoid tumor 159 | 4,369
pilocytic astrocytoma 144 | 3,086
primitive neuroectodermal tumor 143 | 3,031
psoriasis 140 | 6,685
ovarian cancer 139 | 8,484
osteosarcoma 138 | 7,933
oligodendroglioma 130 | 2,849
pediatric high grade glioma 117 | 2,712
ependymoma 105 | 2,514
Carcinoma 100 | 2,147
lung carcinoma 99 | 2,844
subependymal giant cell astrocytoma 96 | 2,287
astrocytic glioma 93 | 2,241
lung cancer 87 | 4,466
Pick disease 84 | 1,893
medulloblastoma 79 | 1,524
adult high grade glioma 78 | 2,148
Epilepsy 74 | 346
malignant mesothelioma 73 | 3,162
pituitary cancer 70 | 1,972
Schizophrenia 64 | 501
posterior fossa group A ependymoma 62 | 1,511
astrocytoma 58 | 1,493
Breast cancer 56 | 3,094
group 3 medulloblastoma 54 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,956
invasive ductal carcinoma 49 | 2,950
Autistic Disorder 47 | 320
Multiple Sclerosis 47 | 498
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
interstitial cystitis 46 | 2,299
lung adenocarcinoma 45 | 2,713
non-small cell lung cancer 45 | 2,798
group 4 medulloblastoma 42 | 1,875
sonic hedgehog group medulloblastoma 42 | 1,482
Eaton-Lambert syndrome 40 | 40
Intellectual disability 40 | 573
colon cancer 40 | 1,475
atypical teratoid/rhabdoid tumor 37 | 1,095
ulcerative colitis 35 | 2,087
Alzheimer's disease 33 | 644
Bipolar Disorder 33 | 266
Parkinson's disease 33 | 364
posterior fossa group B ependymoma 33 | 1,530
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 32 | 2,300
General anesthesia 30 | 53
cystic fibrosis 30 | 1,665
Alcohol dependence 27 | 107
breast carcinoma 27 | 1,614
adrenocortical carcinoma 26 | 1,427
Cancer 25 | 2,346
Toxic encephalopathy 23 | 131
Amyotrophic Lateral Sclerosis 22 | 431
Tonic-clonic epilepsy 22 | 47
active Crohn's disease 22 | 918
gastric carcinoma 22 | 832
Cocaine-Related Disorders 21 | 88
Nicotine dependence 21 | 53
Obesity 20 | 616
Down syndrome 19 | 548
Long QT syndrome 19 | 52
Rheumatoid Arthritis 19 | 1,160
Seizures 19 | 95
diabetes mellitus 19 | 1,663
non primary Sjogren syndrome sicca 19 | 840
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
primary pancreatic ductal adenocarcinoma 19 | 1,271
Local anesthesia 18 | 40
juvenile dermatomyositis 17 | 1,189
cutaneous lupus erythematosus 16 | 1,056
tuberculosis 16 | 1,557
Epilepsy characterized by intractable complex partial seizures 15 | 28
Lennox-Gastaut syndrome 15 | 34
Simple partial seizure 15 | 26
Substance Withdrawal Syndrome 15 | 52
acute quadriplegic myopathy 15 | 1,157
Atrial Fibrillation 14 | 110
Heart disease 14 | 279
fibroadenoma 14 | 557
Attention deficit hyperactivity disorder 13 | 156
Migraine Prevention 13 | 22
Neurodegenerative disease 13 | 383
Partial Epilepsy Treatment Adjunct 13 | 16
Tetanus 13 | 66
Vascular disease 13 | 281
aldosterone-producing adenoma 13 | 664
glioblastoma multiforme 13 | 347
nasopharyngeal carcinoma 13 | 1,056
non-small cell lung carcinoma 13 | 413
Atopic dermatitis 12 | 944
Dementia 12 | 129
Status Epilepticus 12 | 85
active ulcerative colitis 12 | 477
dermatomyositis 12 | 933
primary Sjogren syndrome 12 | 789
progressive supranuclear palsy 12 | 674

Tissue

Female tissues 340 | 18,647
Nervous System 340 | 18,561
Endocrine System 337 | 18,512
Urinary Tract 337 | 18,444
Digestive Tract 336 | 18,473
Liver and Pancreas 333 | 18,136
Cardiovascular System 332 | 17,958
Blood and immune system 331 | 17,995
Male tissues 330 | 17,969
Skin and soft tissues 330 | 18,115
Respiratory system 321 | 17,484

Target Family

Ion Channel 140 | 341
Non-IDG 113 | 11,971
Enzyme 42 | 4,146
Transporter 22 | 473
Kinase 21 | 634
GPCR 4 | 406
Transcription Factor 1 | 1,400

Reactome Pathway

Neuronal System 343 | 343
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Homer protein homolog 1 HOMER1 Tbio Non-IDG -2.39539 267.3 178
Gamma-aminobutyric acid receptor subunit alpha-4 GABRA4 Tclin Ion Channel -1.23686 16.0 235
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123