Development Level

Tchem 12 | 1,890
Tbio 9 | 10,625
Tdark 1 | 7,003

IMPC Term

decreased bone mineral density 2 | 126
decreased startle reflex 2 | 48
increased mean corpuscular hem... 2 | 93
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal digit morphology 1 | 13
abnormal gait 1 | 51
abnormal limb position 1 | 3
abnormal nail morphology 1 | 7
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating phosphat... 1 | 24
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
premature death 1 | 5
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
tail dragging 1 | 1
thrombocytopenia 1 | 46

Disease

psoriasis 15 | 6,685
lung cancer 14 | 4,473
Cancer 13 | 2,346
ovarian cancer 13 | 8,492
glioblastoma 12 | 5,572
osteosarcoma 12 | 7,933
atypical teratoid / rhabdoid tumor 10 | 4,369
malignant mesothelioma 10 | 3,163
diabetes mellitus 8 | 1,663
medulloblastoma, large-cell 8 | 6,234
oligodendroglioma 8 | 2,849
Breast cancer 7 | 3,099
Rheumatoid Arthritis 7 | 1,171
astrocytoma 7 | 1,493
non-small cell lung cancer 7 | 2,798
Multiple myeloma 6 | 1,328
acute quadriplegic myopathy 6 | 1,157
interstitial cystitis 6 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
pancreatic cancer 6 | 2,300
pediatric high grade glioma 6 | 2,712
pilocytic astrocytoma 6 | 3,086
Alzheimer's disease 5 | 644
Atopic dermatitis 5 | 944
Vascular disease 5 | 281
dermatomyositis 5 | 967
ependymoma 5 | 2,514
group 3 medulloblastoma 5 | 2,254
invasive ductal carcinoma 5 | 2,950
lung carcinoma 5 | 2,844
posterior fossa group A ependymoma 5 | 1,511
tuberculosis 5 | 1,563
Amyotrophic Lateral Sclerosis 4 | 432
Neurodegenerative disease 4 | 383
Prostatic Neoplasms 4 | 471
adrenocortical carcinoma 4 | 1,427
colon cancer 4 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
non-small cell lung carcinoma 4 | 413
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
primitive neuroectodermal tumor 4 | 3,031
Adenocarcinoma of lung (disorder) 3 | 48
Brain disease 3 | 84
Cardiomyopathies 3 | 90
Cardiomyopathy, Dilated 3 | 47
Down syndrome 3 | 548
Eye disease 3 | 55
Liver carcinoma 3 | 217
Melanoma 3 | 261
Necrosis 3 | 51
Obesity 3 | 616
Peripheral Neuropathy 3 | 303
Pick disease 3 | 1,893
Toxic encephalopathy 3 | 131
astrocytic glioma 3 | 2,241
chronic lymphosyte leukemia 3 | 232
cutaneous lupus erythematosus 3 | 1,056
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,875
hepatocellular carcinoma 3 | 550
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
lung adenocarcinoma 3 | 2,714
pancreatic carcinoma 3 | 567
primary pancreatic ductal adenocarcinoma 3 | 1,271
sarcoidosis 3 | 368
ulcerative colitis 3 | 2,087
Arthritis 2 | 248
Atherosclerosis 2 | 275
Bipolar Disorder 2 | 266
Brain Ischemia 2 | 87
Colonic Neoplasms 2 | 126
Dementia 2 | 129
Emery-Dreifuss muscular dystrophy 2 | 24
Endometriosis 2 | 535
Lissencephaly 2 | 61
Lung disease 2 | 136
Mammary Neoplasms 2 | 410
Mammary Neoplasms, Experimental 2 | 150
Neoplasm Metastasis 2 | 138
Nerve Degeneration 2 | 73
Parkinson's disease 2 | 364
Polycystic Ovary Syndrome 2 | 335
Reperfusion Injury 2 | 84
Squamous cell carcinoma of esophagus 2 | 82
Stomach Neoplasms 2 | 282
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
acute myeloid leukemia 2 | 785
adult high grade glioma 2 | 2,148
aldosterone-producing adenoma 2 | 664
atypical teratoid/rhabdoid tumor 2 | 1,095
breast carcinoma 2 | 1,614
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 832
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 3 months 2 | 327

Tissue

Blood and immune system 22 | 17,995
Cardiovascular System 22 | 17,958
Digestive Tract 22 | 18,473
Endocrine System 22 | 18,512
Female tissues 22 | 18,647
Liver and Pancreas 22 | 18,136
Male tissues 22 | 17,969
Nervous System 22 | 18,561
Respiratory system 22 | 17,484
Skin and soft tissues 22 | 18,115
Urinary Tract 22 | 18,444

Target Family

Non-IDG 14 | 11,969
Enzyme 5 | 4,146
Transcription Factor 2 | 1,400
Kinase 1 | 634

Reactome Pathway

Neurodegenerative Diseases 22 | 22
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calpain small subunit 1 CAPNS1 Tbio Non-IDG -2.88291 736.0 131
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.68043 45.4 184
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.14287 1340.6 903
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.88928 758.9 787
Tumor necrosis factor ligand superfamily member 6 FASLG Tchem Non-IDG -3.52437 3494.0 818
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94345 80.5 168
14-3-3 protein epsilon YWHAE Tchem Non-IDG -2.20385 158.6 309
Prelamin-A/C LMNA Tbio Non-IDG -3.00663 1039.3 897
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.04076 1184.8 589
Peroxiredoxin-2 PRDX2 Tbio Non-IDG -2.54003 340.8 339