Development Level

Tbio 48 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

decreased total body fat amoun... 6 | 207
decreased circulating HDL chol... 4 | 68
increased lean body mass 4 | 172
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
increased circulating alkaline... 3 | 122
increased circulating chloride... 3 | 41
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
tremors 3 | 39
abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
abnormal locomotor behavior 2 | 24
decreased circulating alkaline... 2 | 46
decreased exploration in new e... 2 | 11
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased pulmonary respirator... 2 | 5
enlarged stomach 2 | 2
impaired glucose tolerance 2 | 75
increased circulating amylase ... 2 | 25
increased mean corpuscular vol... 2 | 92
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
preweaning lethality, complete... 2 | 979
short tibia 2 | 97
small thymus 2 | 16
abnormal bone mineralization 1 | 38
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating glycerol... 1 | 16
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46

Disease

Carcinoma 48 | 11,493
atypical teratoid / rhabdoid tumor 40 | 5,112
medulloblastoma, large-cell 40 | 6,241
glioblastoma 39 | 5,792
ependymoma 36 | 4,679
adult high grade glioma 34 | 3,801
Astrocytoma, Pilocytic 31 | 3,081
Schizophrenia 30 | 1,160
group 3 medulloblastoma 30 | 4,104
ovarian cancer 29 | 8,520
primitive neuroectodermal tumor 28 | 3,035
psoriasis 28 | 6,694
oligodendroglioma 26 | 2,850
Kidney cancer 25 | 2,613
astrocytic glioma 25 | 2,597
Autistic Disorder 22 | 364
osteosarcoma 22 | 7,950
subependymal giant cell astrocytoma 20 | 2,287
lung cancer 18 | 4,740
Intellectual disability 17 | 1,016
pituitary cancer 17 | 1,972
Pick disease 15 | 1,894
lung carcinoma 15 | 2,843
Breast cancer 14 | 3,578
malignant mesothelioma 14 | 3,232
Bipolar Disorder 13 | 666
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Epilepsy 12 | 792
Autism spectrum disorder 11 | 101
invasive ductal carcinoma 11 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
Liver cancer 9 | 604
Melanoma 9 | 711
colon cancer 9 | 1,478
group 4 medulloblastoma 9 | 1,855
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
Parkinson's disease 8 | 392
Toxic encephalopathy 8 | 141
breast carcinoma 8 | 1,638
cystic fibrosis 8 | 1,696
ductal carcinoma in situ 8 | 1,745
pancreatic cancer 8 | 2,398
Alcoholic Intoxication, Chronic 7 | 289
Amyotrophic lateral sclerosis 7 | 451
Autism Spectrum Disorders 7 | 75
Major Depressive Disorder 7 | 301
Mental Depression 7 | 333
Unipolar Depression 7 | 250
Alzheimer's disease 6 | 658
Asperger syndrome 6 | 37
Depressive disorder 6 | 409
astrocytoma 6 | 1,146
medulloblastoma 6 | 720
pediatric high grade glioma 6 | 1,064
Alcoholism 5 | 45
Arteriosclerotic Parkinsonism 5 | 8
Attention deficit hyperactivity disorder 5 | 278
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Extrapyramidal disease 5 | 8
Fragile X syndrome 5 | 34
General anesthesia 5 | 53
Global developmental delay 5 | 608
Influenza A Prevention 5 | 7
Influenza due to Influenza A virus 5 | 7
Local anesthesia 5 | 40
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Neurodevelopmental Disorders 5 | 70
Obesity 5 | 678
Parkinsonism 5 | 18
Poor school performance 5 | 645
Postencephalitic parkinsonism 5 | 12
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
non primary Sjogren syndrome sicca 5 | 891
obsessive-compulsive disorder 5 | 61
Acquired metabolic disease 4 | 336
Alcohol dependence 4 | 107
Cocaine-Related Disorders 4 | 92
Huntington's disease 4 | 76
Large intestine cancer 4 | 126
Nicotine dependence 4 | 54
Pitt-Hopkins syndrome 4 | 20
Rheumatoid arthritis 4 | 1,191
adrenocortical carcinoma 4 | 1,428
gastric carcinoma 4 | 807
nasopharyngeal carcinoma 4 | 1,058
posterior fossa group B ependymoma 4 | 416
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis 4 | 2,010
diabetes mellitus 3 | 1,728

Tissue

Endocrine System 55 | 18,159
Nervous System 55 | 16,725
Female tissues 54 | 17,400
Skin and soft tissues 54 | 17,230
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Urinary Tract 53 | 16,678
Digestive Tract 52 | 17,369
Respiratory system 50 | 16,393
Blood and immune system 48 | 16,909
Cardiovascular System 43 | 15,192

Target Family

Non-IDG 45 | 12,091
Enzyme 6 | 4,145
Ion Channel 5 | 344
GPCR 2 | 408
Kinase 1 | 634

Reactome Pathway

Neurexins and neuroligins 59 | 59
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Brain-enriched guanylate kinase-associated protein BEGAIN Tbio Enzyme -1.29292 19.6 83
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
Leucine-rich repeat transmembrane neuronal protein 3 LRRTM3 Tbio Non-IDG -0.66354 6.01 60
Neurexin-3 NRXN3 Tbio Non-IDG -1.34072 34.8 172
Neurexin-3-beta NRXN3 Tbio Non-IDG -1.34072 34.8 172
Synaptotagmin-2 SYT2 Tbio Non-IDG -1.93503 86.7 222
Disks large-associated protein 3 DLGAP3 Tbio Non-IDG -1.26274 19.1 94
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.75931 60.3 170