Development Level

Tbio 15 | 11,445
Tchem 3 | 1,598
Tclin 2 | 613

IMPC Phenotype

decreased body weight 3 | 161
decreased circulating creatini... 2 | 39
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lactate dehydrogenas... 1 | 16
enlarged heart 1 | 210
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
short tibia 1 | 97

Disease

Carcinoma 17 | 11,493
ovarian cancer 15 | 8,520
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
psoriasis 12 | 6,694
atypical teratoid / rhabdoid tumor 11 | 5,112
Kidney cancer 10 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung cancer 9 | 4,740
osteosarcoma 9 | 7,950
Cancer 8 | 2,499
ependymoma 8 | 4,679
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
oligodendroglioma 7 | 2,850
pancreatic cancer 6 | 2,398
Proteinuria 5 | 144
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
lung adenocarcinoma 5 | 2,716
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Seizures 4 | 596
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non-small cell lung cancer 4 | 2,890
Albuminuria 3 | 21
Alzheimer's disease 3 | 658
Animal Mammary Neoplasms 3 | 136
Autosomal recessive predisposition 3 | 1,442
Cataract 3 | 297
Cognitive delay 3 | 608
Duchenne muscular dystrophy 3 | 601
Focal glomerulosclerosis 3 | 37
Frontal bossing 3 | 157
Global developmental delay 3 | 608
Glomerulosclerosis, Focal Segmental 3 | 28
Hypoplastic mandible condyle 3 | 275
Kidney disease 3 | 430
Lens Opacities 3 | 231
Liver Cirrhosis, Experimental 3 | 769
Liver cancer 3 | 604
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Mandibular hypoplasia 3 | 275
Mental and motor retardation 3 | 608
Micrognathism 3 | 275
Myopia 3 | 176
Nephrotic Syndrome 3 | 78
Orbital separation excessive 3 | 244
Waldenstrons macroglobulinemia 3 | 765
Weight Gain 3 | 100
acute myeloid leukemia 3 | 783
esophageal adenocarcinoma 3 | 737
interstitial cystitis 3 | 2,312
pituitary cancer 3 | 1,972
Adenoid Cystic Carcinoma 2 | 99
Alcoholic Intoxication, Chronic 2 | 289
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Hepatocellular 2 | 228
Cerebral atrophy 2 | 178
Concave bridge of nose 2 | 195
Congenital Epicanthus 2 | 177
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometrial cancer 2 | 311
Failure to gain weight 2 | 365
Hyperreflexia 2 | 209
Hypothyroidism 2 | 122
Infantile onset 2 | 238
Kidney Failure 2 | 111
Liver carcinoma 2 | 240
Melanoma 2 | 711
Nasal bridge wide 2 | 236
Pediatric failure to thrive 2 | 365
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Skin cancer 2 | 469
Stomach Neoplasms 2 | 300
Ventricular Septal Defects 2 | 119
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409

Tissue

Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Liver and Pancreas 20 | 16,750
Urinary Tract 20 | 16,678
Blood and immune system 19 | 16,909
Female tissues 19 | 17,400
Nervous System 19 | 16,725
Male tissues 18 | 17,142
Skin and soft tissues 18 | 17,230
Cardiovascular System 17 | 15,192
Respiratory system 17 | 16,393

Target Family

Non-IDG 12 | 12,091
Kinase 5 | 634
Enzyme 3 | 4,145

Reactome Pathway

Nephrin family interactions 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.54170 33.0 178
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.42514 269.0 268
Alpha-actinin-4 ACTN4 Tbio Non-IDG -2.22522 178.2 300
Kin of IRRE-like protein 3 KIRREL3 Tbio Non-IDG -1.47692 31.9 105
Alpha-actinin-3 ACTN3 Tbio Non-IDG 0.00000 150
Nephrin NPHS1 Tbio Non-IDG -3.16031 1396.4 555
Peripheral plasma membrane protein CASK CASK Tchem Kinase -2.12241 130.2 227
Ras GTPase-activating-like protein IQGAP1 IQGAP1 Tbio Enzyme -2.27732 224.8 291
Cytoplasmic protein NCK2 NCK2 Tbio Non-IDG -1.57587 36.4 241