Development Level

Tbio 30 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
hypoactivity 2 | 132
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal tooth morphology 1 | 24
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
tremors 1 | 39

Disease

ovarian cancer 23 | 8,520
Carcinoma 17 | 11,493
glioblastoma 16 | 5,792
osteosarcoma 15 | 7,950
psoriasis 14 | 6,694
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
ependymoma 12 | 4,679
atypical teratoid / rhabdoid tumor 11 | 5,112
juvenile dermatomyositis 11 | 1,187
Astrocytoma, Pilocytic 10 | 3,081
Cancer 10 | 2,499
adult high grade glioma 10 | 3,801
Influenza 8 | 142
Multiple myeloma 8 | 1,332
cutaneous lupus erythematosus 8 | 1,057
subependymal giant cell astrocytoma 8 | 2,287
astrocytic glioma 7 | 2,597
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
primary Sjogren syndrome 7 | 735
tuberculosis 7 | 2,010
Multiple Sclerosis 6 | 540
Systemic lupus erythematosus 6 | 194
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung carcinoma 6 | 2,843
Influenza, Human 5 | 51
Kidney cancer 5 | 2,613
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
interstitial cystitis 5 | 2,312
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Breast cancer 4 | 3,578
Microphthalmia with limb anomalies 4 | 40
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Anemia 3 | 365
Cerebral atrophy 3 | 178
Melanoma 3 | 711
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
diabetes mellitus 3 | 1,728
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
Adult onset 2 | 82
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Anxiety 2 | 136
Anxiety disease 2 | 113
Asthma 2 | 385
Atopic dermatitis 2 | 952
Autosomal recessive limb-girdle muscular dystrophy type 2H 2 | 7
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Connective tissue disease 2 | 62
Crohn's disease 2 | 321
Dysarthria 2 | 192
Encephalitis 2 | 64
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere 2 | 5
Epilepsy 2 | 792
Glaucoma 2 | 239
HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 2 | 5
Hantavirus pulmonary syndrome 2 | 6
Hepatitis 2 | 67
Hepatitis C 2 | 94
Herpes encephalitis 2 | 6
Intellectual disability 2 | 1,016
Lupus Erythematosus, Systemic 2 | 67
Muscle hypotonia 2 | 571
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Neurodegenerative disease 2 | 414
Pick's disease 2 | 15
Retinitis pigmentosa 42 2 | 9
SINGLETON-MERTEN SYNDROME 1 2 | 2
Schizophrenia 2 | 1,160
Seizures 2 | 596
Singleton-Merten dysplasia 2 | 2
cystic fibrosis and chronic rhinosinusitis 2 | 214
gastric carcinoma 2 | 807
glioblastoma multiforme 2 | 142
group 3 medulloblastoma 2 | 4,104
hepatocellular carcinoma 2 | 547
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
pancreatic cancer 2 | 2,398
posterior fossa group A ependymoma 2 | 468
sarcoidosis 2 | 370
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 10 | 4,145
Kinase 2 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Negative regulators of DDX58/I... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX58 DDX58 Tbio Enzyme -2.96494 922.1 422
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.94112 884.9 183
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Autophagy protein 5 ATG5 Tbio Non-IDG -2.88619 656.2 666
Interferon regulatory factor 3 IRF3 Tbio Transcription Factor -2.84417 662.4 892
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
Interferon-induced helicase C domain-containing protein 1 IFIH1 Tbio Enzyme -2.67869 455.3 335
Ubiquitin-conjugating enzyme E2 D1 UBE2D1 Tbio Non-IDG -2.67434 446.5 194
Mitochondrial antiviral-signaling protein MAVS Tbio Non-IDG -2.60739 413.5 437
TNF receptor-associated factor 3 TRAF3 Tbio Non-IDG -2.50034 309.0 374