Development Level

Tbio 8 | 11,651
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal seminal vesicle morph... 1 | 114
brachydactyly 1 | 19
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
decreased food intake 1 | 13
decreased heart weight 1 | 27
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating creatini... 1 | 38
increased lymphocyte cell numb... 1 | 32
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

Carcinoma 6 | 11,493
ovarian cancer 6 | 8,520
psoriasis 6 | 6,694
Cancer 5 | 2,499
Breast cancer 4 | 3,578
lung cancer 4 | 4,740
Kidney cancer 3 | 2,613
Obesity 3 | 678
cutaneous lupus erythematosus 3 | 1,057
ductal carcinoma in situ 3 | 1,745
invasive ductal carcinoma 3 | 2,951
medulloblastoma, large-cell 3 | 6,241
non-small cell lung cancer 3 | 2,890
osteosarcoma 3 | 7,950
Acquired metabolic disease 2 | 336
Bilateral fifth finger clinodactyly 2 | 110
Blepharoptosis 2 | 231
Breast Neoplasms 2 | 445
Broad nasal tip 2 | 28
Cardiovascular system disease 2 | 246
Cleft Lip 2 | 141
Cleft Palate 2 | 271
Concave bridge of nose 2 | 195
Craniofacial Abnormalities 2 | 151
Cryptorchidism 2 | 296
Curvature of little finger 2 | 110
Decreased size of teeth 2 | 62
Decreased width of tooth 2 | 59
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Epilepsy 2 | 792
Everted lower lip vermilion 2 | 54
Gastroesophageal reflux disease 2 | 110
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Low set ears 2 | 181
Malar flattening 2 | 129
Mammary Neoplasms 2 | 425
Mandibular hypoplasia 2 | 275
Microdontia (disorder) 2 | 59
Micrognathism 2 | 275
Mild Mental Retardation 2 | 70
Neurodegenerative disease 2 | 414
Orbital separation excessive 2 | 244
Patent ductus arteriosus 2 | 90
Penile hypospadias 2 | 106
Protruding lower lip 2 | 54
Schizophrenia 2 | 1,160
Seizures 2 | 596
Small head 2 | 374
Stomach Neoplasms 2 | 300
Strabismus 2 | 270
active Crohn's disease 2 | 922
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
group 3 medulloblastoma 2 | 4,104
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
malignant mesothelioma 2 | 3,232
tuberculosis 2 | 2,010
Agenesis of teeth 1 | 21
Ambiguous Genitalia 1 | 24
Ataxia, Appendicular 1 | 25
Atrophic condition of skin 1 | 25
Bowed and upward slanting eyebrows 1 | 41
Bushy eyebrows 1 | 49
Coloboma 1 | 51
Coughing 1 | 25
Decreased testosterone in males 1 | 28
Deep philtrum 1 | 21
Depressed philtrum 1 | 21
Esophagitis 1 | 35
Flexion contracture - elbow 1 | 32
Fundus coloboma 1 | 18
Gynecomastia 1 | 64
Hyperkyphosis 1 | 111
Hypoplasia of thumb 1 | 26
Kyphosis deformity of spine 1 | 114
Lacrimal Duct Obstruction 1 | 16
Low serum estradiol levels 1 | 22
Lymphosarcoma 1 | 4
Nystagmus, End-Position 1 | 12
Obstruction of nasolacrimal duct 1 | 9
Overfolded helix 1 | 24
Polydactyly preaxial type 1 1 | 9
Premature canities 1 | 24
Primary hypogonadism 1 | 37
Primary physiologic amenorrhea 1 | 55
Progressive microcephaly 1 | 32
Pure gonadal dysgenesis 1 | 19
Reduced number of teeth 1 | 21
Sparse axillary hair 1 | 28
Sparse pubic hair 1 | 31
Streak ovary 1 | 15
Thick vermilion border 1 | 25
Thick, flared eyebrows 1 | 41
Urologic Neoplasms 1 | 8
Wide spaced nipples 1 | 46

Tissue

Nervous System 9 | 16,725
Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Male tissues 8 | 17,142
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Liver and Pancreas 7 | 16,750

Target Family

Transcription Factor 5 | 1,400
Non-IDG 3 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Negative regulation of activit... 9 | 9
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WW domain-containing oxidoreductase WWOX Tbio Enzyme -3.61683 3311.4 251
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786
SUMO-conjugating enzyme UBC9 UBE2I Tbio Non-IDG -2.45979 267.1 368
Transcription factor AP-2-beta TFAP2B Tbio Transcription Factor -1.74089 52.9 225
Transcription factor AP-2-epsilon TFAP2E Tbio Transcription Factor -1.07474 11.3 37
Transcription factor AP-2 gamma TFAP2C Tbio Transcription Factor -1.88406 72.7 269
Transcription factor AP-2-delta TFAP2D Tdark Transcription Factor -0.37805 1.66 118
BTB/POZ domain-containing protein KCTD15 KCTD15 Tbio Non-IDG -1.04860 11.7 176
Transcription factor AP-2-alpha TFAP2A Tbio Transcription Factor -2.48414 289.3 396