Development Level

Tbio 15 | 10,625
Tchem 5 | 1,890
Tclin 1 | 602

IMPC Term

abnormal behavior 2 | 226
decreased body length 2 | 108
decreased total body fat amoun... 2 | 186
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal posture 1 | 5
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 17
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased vertical activity 1 | 22
hypoactivity 1 | 89
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82

Disease

ovarian cancer 16 | 8,484
medulloblastoma, large-cell 12 | 6,234
osteosarcoma 12 | 7,933
Cancer 11 | 2,346
glioblastoma 10 | 5,572
lung cancer 8 | 4,466
oligodendroglioma 8 | 2,849
psoriasis 8 | 6,685
atypical teratoid / rhabdoid tumor 7 | 4,369
non-small cell lung cancer 7 | 2,798
malignant mesothelioma 6 | 3,162
primitive neuroectodermal tumor 6 | 3,031
Pick disease 5 | 1,893
ependymoma 5 | 2,514
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
invasive ductal carcinoma 5 | 2,950
ulcerative colitis 5 | 2,087
Carcinoma 4 | 2,147
Rheumatoid Arthritis 4 | 1,160
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
group 4 medulloblastoma 4 | 1,875
pediatric high grade glioma 4 | 2,712
pilocytic astrocytoma 4 | 3,086
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 674
tuberculosis 4 | 1,557
Breast cancer 3 | 3,094
Leukemia, Myelocytic, Acute 3 | 113
Multiple myeloma 3 | 1,327
acute myeloid leukemia 3 | 780
adult high grade glioma 3 | 2,148
diabetes mellitus 3 | 1,663
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pancreatic cancer 3 | 2,300
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 644
Copper-Overload Cirrhosis 2 | 11
Crohn's disease 2 | 304
Hepatitis, Chronic 2 | 22
Liver Neoplasms, Experimental 2 | 48
Liver carcinoma 2 | 217
Liver disease 2 | 219
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Neoplasm Invasiveness 2 | 127
Neuroblastoma 2 | 78
Nonsyndromic deafness 2 | 121
Parkinson Disease 2 | 102
Pick's disease 2 | 14
Spinocerebellar ataxia type 2 2 | 19
Squamous cell carcinoma 2 | 94
breast carcinoma 2 | 1,614
dermatomyositis 2 | 933
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 2,254
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
non primary Sjogren syndrome sicca 2 | 840
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Anemia 1 | 252
Autistic Disorder 1 | 320
Barrett's esophagus 1 | 183
COPD 1 | 113
Cardiomyopathies 1 | 90
Chronic Lymphocytic Leukemia 1 | 242
Colitis 1 | 46
Colonic Neoplasms 1 | 126
Colorectal Neoplasms 1 | 217
Diabetes Mellitus, Insulin-Dependent 1 | 76
Esophageal Neoplasms 1 | 67
Hematologic cancer 1 | 9
Homocystinuria 1 | 23
Huntington's disease 1 | 72
Immune system cancer 1 | 38
Liver Cirrhosis, Experimental 1 | 108
Liver neoplasms 1 | 109
Lung Neoplasms 1 | 171
Malignant neoplasm of esophagus 1 | 18
Methylmalonic acidemia 1 | 39
Motor neuron disease 1 | 39
Neoplasm Metastasis 1 | 138
Neoplastic Syndromes, Hereditary 1 | 48
Parkinson's disease 1 | 364
Renal Cell Carcinoma 1 | 199
Stomach Neoplasms 1 | 282
Vascular Diseases 1 | 16
Vitamin B12 deficiency 1 | 20
adrenocortical adenoma 1 | 134
interstitial lung disease 1 | 291
ovarian neoplasm 1 | 97

Tissue

Blood and immune system 21 | 17,995
Cardiovascular System 21 | 17,958
Digestive Tract 21 | 18,473
Endocrine System 21 | 18,512
Female tissues 21 | 18,647
Liver and Pancreas 21 | 18,136
Male tissues 21 | 17,969
Nervous System 21 | 18,561
Respiratory system 21 | 17,484
Skin and soft tissues 21 | 18,115
Urinary Tract 21 | 18,444

Target Family

Non-IDG 12 | 11,971
Enzyme 8 | 4,146
Kinase 1 | 634

Reactome Pathway

Negative regulation of MET act... 21 | 21
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Hepatocyte growth factor HGF Tchem Enzyme -3.28069 2317.3 573
Ubiquitin carboxyl-terminal hydrolase 8 USP8 Tchem Enzyme -1.64199 52.9 189
Endophilin-A2 SH3GL1 Tbio Non-IDG -1.91832 115.6 229
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.74208 55.9 226
Endophilin-A3 SH3GL3 Tbio Non-IDG -1.01922 9.86 73
Polyubiquitin-C UBC Tbio Non-IDG -2.87012 56.7 130