Development Level

Tbio 6 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 4 | 11,493
Cleft lip-palate-ectodermal dysplasia syndrome 4 | 8
osteosarcoma 4 | 7,950
atypical teratoid / rhabdoid tumor 3 | 5,112
ductal carcinoma in situ 3 | 1,745
medulloblastoma, large-cell 3 | 6,241
Cancer 2 | 2,499
Cleft Lip 2 | 141
Cleft Palate 2 | 271
Multiple Sclerosis 2 | 540
Syndactyly 2 | 88
adult high grade glioma 2 | 3,801
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
psoriasis 2 | 6,694
Abnormality of hair consistency 1 | 5
Abnormality of hair curl pattern 1 | 5
Abnormality of hair texture 1 | 5
Abnormality of hair volume 1 | 5
Alopecia 1 | 115
Atrial Fibrillation 1 | 124
Bilateral single transverse palmar creases 1 | 34
Bowed and upward slanting eyebrows 1 | 41
Broad flat nasal bridge 1 | 236
Cardiovascular system disease 1 | 246
Cerebral amyloid angiopathy 1 | 13
Cerebrovascular disease 1 | 238
Cleft palate and bilateral cleft lip 1 | 4
Cleft palate with cleft lip 1 | 23
Congenital bile acid synthesis defect 1 | 15
Decreased projection of midface 1 | 105
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Dental abnormalities 1 | 60
Dental caries 1 | 164
Depressed cheekbone 1 | 22
Downward slant of palpebral fissure 1 | 158
Ectodermal Dysplasia 1 | 14
Epidermodysplasia verruciformis 1 | 21
Flattening of the zygomatic bone 1 | 22
Frontotemporal dementia 1 | 51
Herpes simplex 1 | 18
Hypodontia 1 | 81
Hypoplasia of scrotum 1 | 24
Hypoplasia of the zygomatic bone 1 | 22
Hypotrophic cheekbone 1 | 22
Hypotrophic malar bone 1 | 129
Hypotrophic midface 1 | 105
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Liver Cirrhosis, Experimental 1 | 769
Macrotia 1 | 87
Macular degeneration 1 | 65
Malar flattening 1 | 129
Measles 1 | 22
Microdontia (disorder) 1 | 59
Midface retrusion 1 | 105
Nail dysplasia 1 | 52
Nasal bridge wide 1 | 236
Palmoplantar keratosis 1 | 74
Papilloma 1 | 44
Pigmented villonodular synovitis 1 | 9
Pilocytic astrocytoma 1 | 56
Poliomyelitis 1 | 14
Polycystic ovary syndrome 1 | 360
Prominent ear 1 | 56
Protruding ears 1 | 56
Recurrent respiratory infections 1 | 141
Rotting teeth 1 | 73
Small cheekbone 1 | 22
Small midface 1 | 105
Sparse eyebrow 1 | 42
Sparse eyelashes 1 | 31
Sparse hair 1 | 59
Speech Disorders 1 | 58
Subacute sclerosing panencephalitis 1 | 11
Syndactyly of fingers 1 | 48
Syndactyly of the toes 1 | 45
Synophrys 1 | 40
Thick, flared eyebrows 1 | 41
Thin, sparse hair 1 | 59
Tooth Abnormalities 1 | 69
Triangular face 1 | 58
Wide spaced nipples 1 | 46
glioblastoma multiforme 1 | 142
pediatric high grade glioma 1 | 1,064
tuberculosis 1 | 2,010

Tissue

Blood and immune system 6 | 16,909
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678
Cardiovascular System 5 | 15,192

Target Family

Non-IDG 6 | 12,091

Reactome Pathway

Nectin/Necl trans heterodimer... 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nectin-4 NECTIN4 Tbio Non-IDG -2.04277 114.0 151
Poliovirus receptor PVR Tbio Non-IDG -3.43049 2640.6 432
Nectin-2 NECTIN2 Tbio Non-IDG -1.85580 62.9 340
Nectin-1 NECTIN1 Tbio Non-IDG -2.56447 380.0 238
Cell adhesion molecule 3 CADM3 Tbio Non-IDG -1.37538 24.8 219
Nectin-3 NECTIN3 Tbio Non-IDG -1.65024 41.8 247